Catrin Tudur Smith
A5046267575- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Meta-analysis and systematic reviews
- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Ethics in Clinical Research
- Hemoglobinopathies and Related Disorders
- Pancreatic and Hepatic Oncology Research
- Neuroscience and Neuropharmacology Research
- Statistical Methods and Bayesian Inference
- Delphi Technique in Research
- Lung Cancer Treatments and Mutations
- Diet and metabolism studies
- Advanced Causal Inference Techniques
- Preterm Birth and Chorioamnionitis
- Childhood Cancer Survivors' Quality of Life
- Pregnancy and Medication Impact
- Pregnancy-related medical research
- Pharmaceutical studies and practices
- Neuroendocrine Tumor Research Advances
- Schizophrenia research and treatment
- Biomedical Ethics and Regulation
- Reconstructive Surgery and Microvascular Techniques
University of Liverpool
2016-2025
Medical University of Graz
2023
Liverpool Women's Hospital
2008-2023
Cancer Research And Biostatistics
2022
Hesco (United States)
2022
MRC Biostatistics Unit
2019
Aintree University Hospital
2019
Aintree University Hospitals NHS Foundation Trust
2010-2016
Liverpool School of Tropical Medicine
2015-2016
MRC Clinical Trials Unit at UCL
2015
Both gemcitabine (GEM) and fluoropyrimidines are valuable treatment for advanced pancreatic cancer. This open-label study was designed to compare the overall survival (OS) of patients randomly assigned GEM alone or plus capecitabine (GEM-CAP).Patients with previously untreated histologically cytologically proven locally metastatic carcinoma pancreas a performance status <or= 2 were recruited. Patients GEM-CAP. The primary outcome measure survival. Meta-analysis published studies also...
Abstract In a meta‐analysis of randomized controlled trials with time‐to‐event outcomes, an aggregate data approach may be required for some or all included studies. Variation in the reporting survival analyses journals suggests that no single method extracting log(hazard ratio) estimate will suffice. Methods are described which improve upon previously proposed estimating log(HR) from curves. These methods extend to life‐tables. situation where treatment effect varies over time and have...
Points• Systematic reviews are most commonly based on aggregate data extracted from publications or obtained trial investigators.• involving the central collection and analysis of individual participant (IPD) usually larger-scale, international, collaborative projects that can bring about substantial improvements to quantity quality data, give greater scope in analyses, provide more detailed robust results.• The process collecting, checking, analysing IPD is complex than for not all...
Valproate is a first-line treatment for patients with newly diagnosed idiopathic generalised or difficult to classify epilepsy, but not women of child-bearing potential because teratogenicity. Levetiracetam increasingly prescribed these patient populations despite scarcity evidence clinical effectiveness cost-effectiveness. We aimed compare the long-term and cost-effectiveness levetiracetam compared valproate in participants unclassifiable epilepsy.We did an open-label, randomised controlled...
Levetiracetam and zonisamide are licensed as monotherapy for patients with focal epilepsy, but there is uncertainty to whether they should be recommended first-line treatments because of insufficient evidence clinical effectiveness cost-effectiveness. We aimed assess the long-term cost-effectiveness levetiracetam compared lamotrigine in people newly diagnosed epilepsy.This randomised, open-label, controlled trial treatment epilepsy. Adult paediatric neurology services across UK recruited...
Research into the methods used in design, conduct, analysis, and reporting of clinical trials is essential to ensure that effective are available decisions made using results from based on best evidence, which reliable robust. An on-line Delphi survey 48 UK Clinical Collaboration registered Trials Units (CTUs) was undertaken. During round one, CTU Directors were asked identify important topics require methodological research. two, their opinion about level importance each topic recorded,...
Objectives We examined major issues associated with sharing of individual clinical trial data and developed a consensus document on providing access to participant from trials, using broad interdisciplinary approach. Design methods This was consensus-building process among the members multistakeholder task force, involving wide range experts (researchers, patient representatives, methodologists, information technology experts, representatives funders, infrastructures standards development...