A5082059814- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- EEG and Brain-Computer Interfaces
- Retinopathy of Prematurity Studies
- Genomic variations and chromosomal abnormalities
- Functional Brain Connectivity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Glaucoma and retinal disorders
- Drug-Induced Ocular Toxicity
- Metabolism and Genetic Disorders
- Emergency and Acute Care Studies
- Restless Legs Syndrome Research
- Healthcare innovation and challenges
- Glycogen Storage Diseases and Myoclonus
- Disability Rights and Representation
- RNA modifications and cancer
- Homelessness and Social Issues
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and Medication Impact
- Mental Health and Patient Involvement
- Genetic Neurodegenerative Diseases
Swansea University
2020-2024
Aneurin Bevan University Health Board
2013-2024
Royal Gwent Hospital
2012-2024
Institute of Life Sciences
2024
University Hospital of Wales
2003-2014
Charité - Universitätsmedizin Berlin
2013
Eisai (United Kingdom)
2013
Valproate is a first-line treatment for patients with newly diagnosed idiopathic generalised or difficult to classify epilepsy, but not women of child-bearing potential because teratogenicity. Levetiracetam increasingly prescribed these patient populations despite scarcity evidence clinical effectiveness cost-effectiveness. We aimed compare the long-term and cost-effectiveness levetiracetam compared valproate in participants unclassifiable epilepsy.We did an open-label, randomised controlled...
Levetiracetam and zonisamide are licensed as monotherapy for patients with focal epilepsy, but there is uncertainty to whether they should be recommended first-line treatments because of insufficient evidence clinical effectiveness cost-effectiveness. We aimed assess the long-term cost-effectiveness levetiracetam compared lamotrigine in people newly diagnosed epilepsy.This randomised, open-label, controlled trial treatment epilepsy. Adult paediatric neurology services across UK recruited...
Epilepsy is a serious neurological disorder affecting the quality of life (QoL) people with this condition. A survey was conducted in five European countries (France, Germany, Italy, Spain, and UK) to understand impact burden epilepsy its treatment on lives (PWE).Five hundred PWE (taking >1 antiseizure medication [ASM]) 500 matched controls completed 30-minute online questionnaire. The 12-Item Short Form Survey (SF-12) used measure QoL Neurological Disorders Depression Inventory for (NDDI-E)...
Abstract In this retrospective, multicentre, observational cohort study, we sought to determine the clinical, radiological, EEG, genetics and neuropathological characteristics of mitochondrial stroke-like episodes identify associated risk predictors. Between January 1998 June 2018, identified 111 patients with genetically determined disease who developed episodes. Post-mortem cases (n = 26) were from Newcastle Brain Tissue Resource. The primary outcome was interrogate...
Abstract Background We are a research team of clinical, academic and advocacy‐based researchers with without learning disabilities, working on the Humanising Healthcare (for people disabilities) project. The project is dedicated to finding sharing healthcare practices that enhance lives disabilities. As part our ethics applications access National Health Service study sites for fieldwork, we worked together write guiding principles co‐producing In this paper, introduce these Participatory...
Carbamazepine (CBZ), oxcarbazepine (OXC), and eslicarbazepine acetate (ESL) belong to the dibenzazepine family of antiepileptic drugs are all thought primarily act as sodium channel blockers (SCBs). However, ESL is structurally distinct from CBZ OXC, resulting in differences metabolism, pharmacokinetics, pharmacodynamics. Despite a lack direct comparative data, evidence for potential effectiveness tolerability within has emerged studies which patients being treated with one agent have...
Abstract Objective This study was undertaken to validate a set of candidate biomarkers seizure susceptibility in retrospective, multisite case–control study, and determine the robustness these derived from routinely collected electroencephalography (EEG) within large cohort (both epilepsy common alternative conditions such as nonepileptic attack disorder). Methods The database consisted 814 EEG recordings 648 subjects, eight National Health Service sites across UK. Clinically noncontributory...
To assess the impact of epilepsy and antiseizure medications (ASMs) on sleep quality in people with (PWE).An online survey was conducted France, Germany, Italy, Spain UK among PWE taking >1 ASM matched controls. Sleep evaluated using Pittsburgh Quality Index (PSQI). Associations between (global PSQI) overall life (QoL; assessed 12-Item Short Form Survey [SF-12]) depressive symptoms (assessed Neurological Disorders Depression Inventory for Epilepsy [NDDI-E]) were also evaluated.Overall, 500...
The purpose of the study was to determine whether in utero exposure vigabatrin caused visual field loss. Three mothers with four children who had been exposed and were subsequently formula fed identified. All seven individuals underwent perimetry imaging retinal nerve fiber layer (RNFL). yielded reliable outcomes RNFL images acceptable quality. Two three exhibited vigabatrin-attributed loss an abnormally attenuated RNFL. third upper left quadrantanopia, consistent previous temporal lobe...
Sodium valproate remains the best drug for idiopathic generalised epilepsy. For men with latter diagnosis, this is of choice. has an unacceptably high level major fetal malformation and also causes learning disabilities in many children exposed to utero. Women reproductive age should not normally be offered drug. There are women refractory epilepsy who would benefit from planning pregnancy. Individualised care gold standard, blanket bans on choice based gender.
Clinical practice studies help guide antiepileptic drug (AED) therapy in patient groups routinely excluded from clinical trials, such as the elderly. The Euro-Esli study investigated effectiveness and safety/tolerability of eslicarbazepine acetate (ESL) when used everyday Europe. A subanalysis data elderly patients (≥ 60 years) included was conducted to assess these aspects ESL use this population. a pooled analysis 14 European studies. Effectiveness parameters responder 50% seizure...
Background A quarter of people with intellectual disability (ID) have epilepsy, compared to approximately one in a hundred across the general population. Evidence for safe and effective prescribing antiepileptic drugs (AEDs) those ID is, however, limited. Aims Study This study seeks strengthen research evidence around Eslicarbazepine Acetate (ESL), new AED, by comparing response individuals from population who do not ID. Methods single data set was created through retrospective collection...
Cerebellar ataxia is a common neurological presentation. It can be acute, subacute or chronic. Neurological complications of Epstein-Barr virus (EBV) are well-recognised with variety presentations. Acute cerebellar rare, but an established complication. has been described as the sole manifestation EBV infection without systemic features infectious mononucleosis. The pathophysiology not clear. course illness may last for few months benign outcome, though serious happen. We present case...
Seizures occur in around 13% of patients with cancer and can be distressing for family members to witness. In those unable manage regular antiepileptic medications, midazolam administered subcutaneously using a syringe driver, but this may cause sedation. Brivaracetam is newer drug licensed as an adjunctive therapy the treatment partial-onset seizures or without secondary generalisation restricted use refractory epilepsy. It associated fewer behavioural psychiatric side effects than...
Introduction There is growing recognition that in order to remain sustainable, the UK’s National Health Service must deliver best patient outcomes within available resources. This focus on relative cost basis of value-based healthcare (VBHC) and has led interest recording patient-reported outcome measures (PROMs) measure perspectives impact a health condition their lives. Every board Wales now required collect PROMS as part routine care. We will evaluate VBHC programme implemented lead...
As in other hospital specialties, an increasing proportion of neurology trainees are female. To predict the workforce implications it is necessary to determine what life choices future neurologists will make. A questionnaire survey was administered consultants and trainees, general medical senior house officers, students. Of 344 respondents, 3% specialist registrars (SpRs) 4.6% work part time. Eighty-seven per cent female 22% male junior doctors plan time for, on average, 7.5 1.5 years...
An 18-year-old woman was admitted with recurrent seizures. These began focally in the left leg and rapidly generalised. She had complained of a mild generalised headache for preceding 4 weeks, associated rainbow-coloured lights her central vision. On admission, she reported formed visual hallucinations, which included animals vehicles. been previously well, drank little alcohol, did not smoke, took only an oral contraceptive pill no significant family history. On examination, apyrexial....