A5040334367- Epilepsy research and treatment
- Neurological disorders and treatments
- Neurology and Historical Studies
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Metabolism and Genetic Disorders
- Glioma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Psychosomatic Disorders and Their Treatments
- Multiple Sclerosis Research Studies
- EEG and Brain-Computer Interfaces
- Parkinson's Disease Mechanisms and Treatments
- Hallucinations in medical conditions
- Brain Metastases and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disorders and Treatments
- Traumatic Brain Injury Research
- Intracranial Aneurysms: Treatment and Complications
- Infectious Encephalopathies and Encephalitis
- Cerebral Venous Sinus Thrombosis
- Genomics and Rare Diseases
- History of Medicine Studies
- Nerve Injury and Rehabilitation
- Mental Health and Psychiatry
Royal United Hospital Bath NHS Trust
2023
Royal United Hospital
2023
University of Cambridge
1998-2021
Collaborative Group (United States)
2021
King's College London
2020
Addenbrooke's Hospital
2001-2018
Cambridge University Hospitals NHS Foundation Trust
2013-2015
Bedford Hospital NHS Trust
2015
Bedford Hospital
1998-2010
Rosie Hospital
2009
Valproate is a first-line treatment for patients with newly diagnosed idiopathic generalised or difficult to classify epilepsy, but not women of child-bearing potential because teratogenicity. Levetiracetam increasingly prescribed these patient populations despite scarcity evidence clinical effectiveness cost-effectiveness. We aimed compare the long-term and cost-effectiveness levetiracetam compared valproate in participants unclassifiable epilepsy.We did an open-label, randomised controlled...
Levetiracetam and zonisamide are licensed as monotherapy for patients with focal epilepsy, but there is uncertainty to whether they should be recommended first-line treatments because of insufficient evidence clinical effectiveness cost-effectiveness. We aimed assess the long-term cost-effectiveness levetiracetam compared lamotrigine in people newly diagnosed epilepsy.This randomised, open-label, controlled trial treatment epilepsy. Adult paediatric neurology services across UK recruited...
The differentiation of frontal lobe epilepsy (FLE) and temporal (TLE) is a clinical problem major theoretical practical importance. Current electroclinical classification based on retrospective studies highly selected patients. When applied to the presurgical evaluation patients, it has poor specificity. current study adopts different prospective approach analysis ictal manifestations their value in differentiating FLE TLE. Two hundred fifty-two patients with partial were according criteria...
In this prospective, population-based study of 594 cases newly diagnosed epilepsy, proportions in categories as defined by the International League Against Epilepsy (ILAE) were follows: (1) localization-related epilepsies: 1.1* idiopathic, 1.2%; 1.2* symptomatic, 16.2%; and 1.3 cryptogenic, 24.6%; (2) generalized 2.1* idiopathic (idiopathic epilepsy) with 3-Hz spike wave: absence 2.2%; juvenile myoclonic 1.5%; nonspecific 5.6%; 2.3.1* symptomatic epilepsies, 2.3.2* specific syndromes 0.3%;...
Many people with Parkinson disease (PD) develop motor complications that are uncontrolled by levodopa dose adjustment. Among these patients, it is uncertain which drug class more effective as adjuvant therapy.To compare the long-term effects on patient-rated quality of life adding a dopamine agonist vs reuptake inhibitor (DRI), either monoamine oxidase type B (MAO-B) or catechol-O-methyltransferase (COMT) inhibitor, to therapy for treatment patients PD.This pragmatic semifactorial (2 × 1)...
OBJECTIVES--To define the clinical characteristics of a group patients with startle provoked epileptic seizures (SPES). METHODS--Nineteen were identified during course larger study seizure patterns. A witnessed account was obtained in all patients; interictal EEG 18, video-EEG-telemetry eight, CT and high resolution MRI eight. RESULTS--The onset SPES childhood or adolescence 14 19 patients. It preceded by exclusively spontaneous nine had been replaced two Sudden noise main triggering...
Dr Panayiotopoulos has written this monograph cum swan song about the syndrome that he put on diagnostic map and to which his name been attached. This childhood certainly breaks many “epilepsy rules”. The seizures usually start with autonomic symptoms nausea, retching, or vomiting evolve altered awareness only after several minutes. Tonic deviation of …
Abstract Background We report striking and unanticipated improvements in maladaptive behaviours Prader–Willi syndrome (PWS) during a trial of vagus nerve stimulation (VNS) initially designed to investigate effects on the overeating behaviour. PWS is genetically determined neurodevelopmental disorder associated with mild–moderate intellectual disability (ID) social behavioural difficulties, alongside characteristic severe hyperphagia. Methods Three individuals underwent surgery implant VNS...
Genetics of Focal Epilepsies . Edited by s f berkovic, p genton, e hirsch, and picard. (Pp 286, £59.00). Published John Libbey Co, London, 1999. ISBN 0 86196 569 8. Are we on the verge molecular Armageddon, to be ravaged onslaught giant, genetically modified, giant tomatoes? Are entering a Utopia, where all world's ills will solved with golden key nucleotide code or at gateway eugenic nightmare? As far as epilepsy is concerned, central message this book that clinical heterogeneity rule—the...
Epilepsy and pregnancy . Edited by t tomson, l gram, m sillanpaa, s i johannessen. (Pp 215; £38.00.) Published Wrightson biomediacal publishing, Petersfield. 1997. ISBN 1 871816 36 X. The use of antiepileptic drugs in women childbearing age is one the most thorny issues regularly facing neurologists. The stakes are high but there no universally agreed approach to management. This book explores various aspects problem, including teratogenicity, epilepsy control pregnancy, consequence seizures …
<h3>Importance</h3> Mitochondrial DNA (mtDNA) disorders have emerged as major causes of inherited neurologic disease. Despite being well recognized for more than 2 decades, the clinical presentation continues to broaden. The phenotypic heterogeneity is partly owing different percentage levels mutant mtDNA heteroplasmy in tissues, but factors influencing this are poorly understood. <h3>Observations</h3> This case report describes monozygotic male twins with ptosis, optic atrophy, and...
pilepsy enters the diVerential diagnosis of paroxysmal disorders central nervous system function.The first step is to diVerentiate seizures from other common disorders, which are considered in another section (see p ii9).When recurrent confirmed next diagnose epilepsy syndrome order estimate prognosis and optimise treatment.The following guiding principles useful considering attack disorders.c The nature creates significant limitations diagnostic precision.c great majority cause an ictal...
Patient selection for seizure prophylaxis after traumatic brain injury (TBI) and duration of anti-epileptic drug treatment patients with early post-traumatic seizures (PTS), remain plagued uncertainty. In 2017, a collaborative group neurosurgeons, neurologists, neurointensive care rehabilitation medicine physicians was formed in the UK aim assessing variability current practice gauging degree uncertainty to inform design future studies. Here we present results survey clinicians managing TBI...
Seizures and Epilepsy in the Elderly. Edited bya james rowan r eugene ramsey. (Pp 343). Published by Butterworth-Heinemann, Oxford, 1997. ISBN 0-7506-9622-2. The incidence of epilepsy rises sharply over age 60 with an ever-increasing elderly population, it is becoming area increasing clinical social importance. The limitations current knowledge, especially relation to treatment directions for future research, are considered a valuable penultimate chapter this book, that would have been well...
✓ The patient in this report had a parasagittal meningioma with an intrasinus extension that presented features of benign intracranial hypertension and no focal neurological deficit or seizure. was managed combination endovascular stent placement radiotherapy. authors describe the investigation technical aspects for stenosed sinus. Good symptomatic relief achieved.
Four patients had prolonged, sensory, simple partial seizures (SPS), lasting up to several days, without associated behavioural impairment. In three patients, the SPS often occurred as a prolonged "aura" before more overt seizure. Descriptions included: "butterflies", rising epigastric sensation; "a thought in stomach", and an olfactory sensation. Seizure localisation was frontal one case, temporal two cases uncertain case. These sensations may represent under-reported form of continuous,...
Posterior reversible encephalopathy syndrome (PRES) is a rare-and not always reversible-neurological complication associated with pre-eclampsia. We report highly unusual case of puerperal PRES occurring in the context pre-eclampsia arising from previously undiagnosed triploid pregnancy at 16 weeks gestation.