A5012392332- Acute Ischemic Stroke Management
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Cholesterol and Lipid Metabolism
- Dysphagia Assessment and Management
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Intracerebral and Subarachnoid Hemorrhage Research
- RNA Research and Splicing
- Tracheal and airway disorders
- Gene expression and cancer classification
- Breast Cancer Treatment Studies
- Circular RNAs in diseases
- Monoclonal and Polyclonal Antibodies Research
- Military History and Strategy
- RNA and protein synthesis mechanisms
- Probiotics and Fermented Foods
- Neurology and Historical Studies
- Cancer Immunotherapy and Biomarkers
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neurological disorders and treatments
- Drug Transport and Resistance Mechanisms
- Legume Nitrogen Fixing Symbiosis
University of Leeds
2016-2025
York St John University
2023-2025
University Hospital of Wales
2015-2024
Wellcome Trust
2008-2024
St James's University Hospital
2012-2024
Cardiff and Vale University Health Board
2016-2023
Australian Regenerative Medicine Institute
2023
Monash University
2023
Argenx (Belgium)
2023
Centre for Mental Health
2022
RECOMMENDATIONS IntroductionPhysiotherapy should be offered to patients with a variety of medical respiratory conditions, the aim breathlessness management and symptom control, mobility function improvement or maintenance, airway clearance cough enhancement support.Strategies techniques include: rehabilitation, exercise testing (including for ambulatory oxygen assessment), prescription, clearance, positioning breathing techniques.Physiotherapy may helpful postural and/or musculoskeletal...
The amphipathic helix hypothesis for the lipid-associating domains of exchangeable plasma apolipoproteins has been further studied by analysis structure complexes formed between four synthetic peptide analogs and dimyristoyl phosphatidylcholine (DMPC). Density gradient ultracentrifugation, negative stain electron microscopy, nondenaturing gel electrophoresis, 1H NMR, high sensitivity differential scanning calorimetry, circular dichroism were techniques used in these studies. two...
Approximately 30 % of breast cancer patients receive chemotherapy, yet little is known about influences current regimens on circulating lymphocyte levels and phenotypes. Similarly, clinico-pathological factors that modify these influences, implications for future immune health remain mainly unexplored.We used flow-cytometry to assess phenotypes in 88 primary before chemotherapy at time-points from 2 weeks 9 months after completion. We examined titres antibodies against pneumococcal tetanus...
<b><i>Objective:</i></b> To compare the incidence of dementia in PD with that a control group without PD, and to assess relationship between other features PD. <b><i>Methods:</i></b> The authors recruited 83 patients 50 controls, all at initial assessment, assessed them regular intervals over maximum period 122 months. Dementia was diagnosed according objective criteria, included judgment by researchers masked subject variables putatively associated dementia. <b><i>Results:</i></b> Seventeen...
To compare the mortality rate in Parkinson's disease (PD) with a control group without PD, and to assess relationship between features of PD.Ninety PD patients 50 controls, ascertained at 11 years follow-up.The hazard ratio (HR) for compared controls was 1.64 (95% CI: 1.21-2.23). Multivariate analysis showed age, dementia depression were independent predictors but age onset severity neurological symptoms not. The HR 1.09 1.05-1.13), 1.94 1.26-2.99), 2.66 1.59-4.44).Mortality is increased...
We studied clinical features potentially related to dysphagia and three indices from a timed test of swallowing--average volume per swallow (ml), average time (s) swallowing capacity (ml/s)--in 181 screened healthy adults 30 patients with motor neurone disease (MND). In adults, age, sex height accounted for 44.3% 55.6% the variance log capacity, respectively. Symptoms signs were more prevalent in MND group associated reduced swallow; repeatability studies on these two both groups showed that...
Abstract Purpose: Previous conflicting results about the prognostic significance of estrogen receptor (ER)-β in breast cancer may be explained by contribution isoforms, which five exist. Our aim was to elucidate ERβ1, ERβ2, and ERβ5 immunohistochemistry a large cohort carcinomas with long-term follow-up. Experimental Design: Tissue microarrays were stained antibodies scored as percentage positive tumor cells using Allred system. Nuclear cytoplasmic staining evaluated correlated...
Cancer cells are highly dependent on glycolysis. Our aim was to determine if switching metabolism from glycolysis towards mitochondrial respiration would reduce growth preferentially in colorectal cancer over normal cells, and examine the underlying mechanisms.
Colorectal cancer-specific biomarkers have been used as molecular targets for fluorescent intra-operative imaging, targeted PET/MRI, and selective cytotoxic drug delivery yet the selection of is rarely evidence-based. We evaluated sensitivities specificites four most commonly markers: carcinoembryonic antigen (CEA), tumour-associated glycoprotein-72 (TAG-72), folate receptor-α (FRα) Epithelial growth factor receptor (EGFR).Marker expression was semi-quantitatively in matched mucosal...
Carcinoma-associated fibroblasts (CAFs) influence the behaviour of cancer cells but roles microRNAs in this interaction are unknown. We report that differentially expressed between breast normal and CAFs oestrogen receptor-positive cancers, explore influences one these, miR-26b, on biology. identified by expression profiling clinical samples a tissue culture model: miR-26b was most highly deregulated microRNA. Using qPCR, confirmed as down-regulated from 15 18 further cancers. Next, we...
Delivery of chemotherapy drugs specifically to cancer cells raises local drug doses in tumors and therefore kills more while reducing side effects other tissues, thereby improving oncological quality life outcomes. Cubosomes, liquid crystalline lipid nanoparticles, are potential vehicles for delivery drugs, presenting the advantages biocompatibility, stable encapsulation, high loading hydrophobic or hydrophilic drugs. However, active targeting drug-loaded cubosomes cells, as opposed passive...
Nanomedicines, while having been approved for cancer therapy, present many challenges such as low stability, rapid clearance, and nonspecificity leading to off-target toxicity. Cubosomes are porous lyotropic liquid crystalline nanoparticles that have shown great premise drug delivery vehicles; however, their behavior in vivo is largely underexplored, hindering clinical translation. Here, we engineered cubosomes based on the space group Im3m loaded with copper acetylacetonate a model drug,...
Glioblastoma (GBM) brain tumors lacking IDH1 mutations (IDHwt) have the worst prognosis of all neoplasms. Patients receive surgery and chemoradiotherapy but almost always fatally recur.
<h2>Summary</h2><h3>Background</h3> The highest priority uncertainty for people with symptomatic cerebral cavernous malformation is whether to have medical management and surgery or alone. We conducted a pilot phase randomised controlled trial assess the feasibility of addressing this in definitive trial. <h3>Methods</h3> CARE was prospective, randomised, open-label, assessor-blinded, parallel-group at neuroscience centres UK Ireland. aimed recruit 60 any age, sex, ethnicity who had mental...
Purified apolipoprotein A-I has been separated by reversed-phase high performance liquid chromatography (HPLC) into multiple peaks and these have characterized.One peak, apoA-Ib had a relatively longer retention time on HPLC but its could be shortened treatment hydrogen peroxide.CNBr cleavage studies indicated that the differences in oxidation product, apoA-la, were due to different states of methionine.This phenomenon was also observed apoA-11, where methionine produced two more forms this...
Abstract Estrogen receptor β1 (ERβ1) downregulation occurs in many breast cancers, but the responsible molecular mechanisms remain unclear. Here, we report that levels of ERβ1 expression are negatively regulated by microRNA miR-92. Expression analysis a cohort primary tumors confirmed significant negative correlation between miR-92 and both mRNA protein. Inhibition MCF-7 cells increased dose-dependent manner, whereas overexpression led to downregulation. Reporter constructs containing...
Increased eukaryotic translation initiation factor 4E (eIF4E) expression occurs in many cancers, and makes fundamental contributions to carcinogenesis by stimulating the of cancer-related genes at post-transcriptional levels. This key role is highlighted facts that eIF4E levels can predict prognosis, an established therapeutic target. However, activity a complex function phosphorylation statuses eIF4E-binding proteins (4E-BPs). Our hypothesis was combined analyses these pathway components...