A5112377118- Gallbladder and Bile Duct Disorders
- Bariatric Surgery and Outcomes
- Appendicitis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
- Body Contouring and Surgery
- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Surgical Simulation and Training
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Monoclonal and Polyclonal Antibodies Research
- Diverticular Disease and Complications
- Intraperitoneal and Appendiceal Malignancies
- Enhanced Recovery After Surgery
- Pancreatic and Hepatic Oncology Research
- Biliary and Gastrointestinal Fistulas
- Radiopharmaceutical Chemistry and Applications
- Hip and Femur Fractures
- Colorectal Cancer Surgical Treatments
- Hernia repair and management
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- Obesity and Health Practices
- Diversity and Career in Medicine
Ambrose Alli University
2025
Irrua Specialist Teaching Hospital
2025
Calderdale and Huddersfield NHS Foundation Trust
2011-2024
Huddersfield Royal Infirmary
2018-2023
York Teaching Hospital NHS Foundation Trust
2016-2017
Scarborough General Hospital
2014-2016
Bradford Royal Infirmary
2014
Bradford Teaching Hospitals NHS Foundation Trust
2014
University of Leeds
2008-2010
Leeds General Infirmary
2008-2010
Increased eukaryotic translation initiation factor 4E (eIF4E) expression occurs in many cancers, and makes fundamental contributions to carcinogenesis by stimulating the of cancer-related genes at post-transcriptional levels. This key role is highlighted facts that eIF4E levels can predict prognosis, an established therapeutic target. However, activity a complex function phosphorylation statuses eIF4E-binding proteins (4E-BPs). Our hypothesis was combined analyses these pathway components...
Tamoxifen remains therapy of choice for premenopausal estrogen receptor alpha-positive breast cancer. However, resistance and recurrence are serious problems. Our previous work indicated that carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) was significantly up-regulated in tamoxifen-resistant (TAMr) MCF-7 derivatives. The aim this study to determine the functional role CEACAM6 endocrine-resistant cancer retrospectively test whether it predictive a large cohort cancers with...
Aims: To assess mothers' knowledge of childhood malnutrition prevention practices at Ugbor Primary Health Centre, Benin City, Nigeria; identify socio-demographic factors influencing these and provide recommendations for targeted interventions. Study Design: Descriptive cross-sectional study. Place Duration Study: Centre (PHC), Edo State, Nigeria, conducted from February 2024 to August, 2024. Methodology: A total 167 mothers, aged 18 years above, attending the immunization clinic were...
Abstract Oestrogen receptors (ERs) are critical regulators of the behaviour many cancers. Despite this, roles and regulation one two known ERs – ERβ– poorly understood. This is partly because analyses have been confused by discrepancies between ERβ expression at mRNA proteins levels, expressed as several functionally distinct isoforms. We investigated human 5′ untranslated regions (UTRs) their influences on function. demonstrate that alternative 5′UTRs potent differential acting level...
Abstract Background A major shift in treatment of appendicitis occurred early the SARS-CoV-2 pandemic with non-operative management used commonly outside research protocols and units limited previous experience. This study aims to compare real-world outcomes surgery versus uncomplicated children 1-year follow-up. Method prospective multicentre observational treated for at 74 hospitals UK Ireland from 1 April 31 July 2020 was performed. Propensity-score matched analysis conducted using age,...
An effective surgical handover is imperative to optimise patient care and safety, whilst ensuring progression of clinical management the delivery an efficient service. The introduction full-shift working, as a response progressive implementation European Working Time Directive (EWTD), has placed spotlight on doctor safety. Effective between shifts vital protect safety assist doctors with governance. weekend critical point where transfer ongoing team efficient, thorough informative, this in...
An operation note is a medicolegal document. The Royal College of Surgeons (RCS) England's Good Surgical Practice 2014 (GSP) sets out 19 points an should include. This study aimed to assess if the introduction electronic patient record (EPR) improved quality general surgical notes. annonymised retrospective case review notes was undertaken over five separate time periods. first cycle consisted periods 1 (prior EPR implementation), 2 (1 week after EPR) and 3 (4 weeks EPR). Period 4 reaudit...
Postoperative wound complications after excisional surgery for primary breast cancer can result in patients requiring additional treatments and delay adjuvant therapy are associated with worse prognoses.We investigated factors that might predispose to complications.A number of patient characteristics have been complications, but there is currently no quantitative measure the risk their occurrence. Our hypothesis was related, part, immune status patients.We recruited undergoing determined...
The potential role of the androgen receptor (AR) as a predictive or prognostic factor in breast cancer remains unclear. We aimed to determine significance AR cohort carcinomas with long-term follow-up and critically appraise this context existing literature. Four hundred eight cases invasive were incorporated into tissue microarrays (TMAs). All received tamoxifen comprised 108 which relapsed 300 did not. Mean time for former was 84 months (range 1-142, SD 38.8) latter 77 11-229, 49.7). TMAs...
We aimed to assess outcomes in patients undergoing sequential intragastric balloon (IGB) treatment for obesity. Consecutive who underwent between May 2014 and February 2023 were identified. recorded including: weight at 3-monthly intervals, progression definitive bariatric procedure morbidity. Forty-five Median loss with first IGB was 15.2 kg (8.8%). 11 (26.7%) had a second IGB, median of 3.3 (1.9%). Twenty-one (46.7%) suitable surgery after treatment. One further patient (2.2%) IGB. During...
Renal cell cancers are among the great mimics in surgery as they present with myriad symptoms unrelated to renal cancer. This patient also interestingly had an incidental finding of porcelain gall bladder.