A5061253643- Reproductive System and Pregnancy
- AI in cancer detection
- Reproductive Biology and Fertility
- Radiomics and Machine Learning in Medical Imaging
- Preterm Birth and Chorioamnionitis
- Ovarian cancer diagnosis and treatment
- Ovarian function and disorders
- Reproductive Physiology in Livestock
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Pregnancy and preeclampsia studies
- Molecular Biology Techniques and Applications
- Sperm and Testicular Function
- Peripheral Artery Disease Management
- Pregnancy-related medical research
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Fatty Acid Research and Health
- Cancer Genomics and Diagnostics
- Cell Image Analysis Techniques
- Pregnancy and Medication Impact
- Breast Cancer Treatment Studies
- Diet and metabolism studies
- Neuroendocrine Tumor Research Advances
St James's University Hospital
2016-2025
University of Leeds
2012-2025
Wellcome Trust
2014-2025
Leeds Teaching Hospitals NHS Trust
2010-2024
Methodist Hospital
2022
Cooper University Hospital
2022
University of Chicago
2022
Thomas Jefferson University Hospital
2022
University College London Hospitals NHS Foundation Trust
2022
University College London
2022
BACKGROUND: Metformin appears to improve reproductive function in some women with polycystic ovary syndrome (PCOS). We wished explore the effect of metformin PCOS undergoing IVF. METHODS: A randomized, placebo-controlled, double-blind study was carried out between 2001 and 2004. Patients IVF/ICSI treatment using a long GnRH agonist protocol were randomized receive (MET), 850 mg, or placebo (PLA) tablets twice daily from start down-regulation process until day oocyte collection. The primary...
Oxidative damage due to the production of reactive oxygen species (ROS) is one a number culture-induced stresses which may compromise preimplantation embryo development in vitro. Ethylenediaminetetraacetic acid (EDTA), reduced tension, superoxide dismutase (SOD) and catalase (CAT) offer protection against oxidative stress, but few attempts have been made determine these agents, or combination, most effective. In particular, no systematic investigation their actions interactions has using...
Three-dimensional (3D) reconstruction and examination of tissue at microscopic resolution have significant potential to enhance the study both normal disease processes, particularly those involving structural changes or in which spatial relationship features is important. Although other methods exist for studying 3D, using conventional histopathological has advantages because it allows staining interpretation techniques. Until now, its use not been routine research technical difficulty...
Variations in systemic inflammatory response biomarker levels have been associated with adverse clinical outcome various malignancies. This study determined the prognostic significance of preoperative neutrophil:lymphocyte (NLR), platelet:lymphocyte (PLR) and monocyte:lymphocyte (MLR) ratios endometrial cancer. Clinicopathological 5-year follow-up data were obtained for a retrospective series surgically treated cancer patients (n=605). Prognostic was overall (OS) cancer-specific survival...
Carbapenemase-producing Enterobacteriaceae (CPE), including KPC-producing Klebsiella pneumoniae (KPC-Kpn), are an increasing threat to patient safety. To use WGS investigate the extent and complexity of carbapenemase gene dissemination in a controlled KPC outbreak. with reduced ertapenem susceptibility recovered from rectal screening swabs/clinical samples, during 3 month outbreak (2013–14), were investigated for production, antimicrobial susceptibility, variable-number-tandem-repeat profile...
Bovine oocyte maturation in vitro frequently results abnormal cytoplasmic and failure to acquire developmental competence. This is, part, likely be due the non-physiological nutritional milieu which oocytes are exposed. Improvements potential may achieved by modelling nutrient profiles on those of preovulatory follicular fluid (FF). However, little is known about fluctuations FF levels according follicle dominance oestrous cyclicity. study therefore characterised carbohydrate amino acid...
Objective To determine the relationship between high vaginal pro-inflammatory cytokines and cervical shortening in women at risk of spontaneous preterm labor to assess influence cerclage progesterone on this relationship. Methods This prospective longitudinal observational study assessed 112 with least one previous delivery 16 34 weeks' gestation. Transvaginal length was measured cervico-vaginal fluid sampled every two weeks until 28 weeks. If cervix shortened (<25 mm) before 24 gestation,...
The accumulation of ammonium is a major artefact in vitro embryo culture. This study has examined production and potential mechanisms disposal preimplantation bovine blastocysts. Embryos were produced by maturation fertilisation oocytes, cultured synthetic oviduct fluid containing amino acids BSA (SOFaaBSA). Ammonium/urea concentrations determined enzymatically. Amino acid appearance/disappearance ‘profiles’ single blastocysts at 0, 1.25 2.5 mM NH 4 Cl (with or without 0.33 pyruvate), with...
Myometrial inflammation is thought to have a pivotal role in the onset of term and some forms preterm labour. This based on comparison samples taken from women undergoing elective CS prior labour with those established Consequently, it not clear whether myometrial cause or consequence Our objective test hypothesis that To this hypothesis, we obtained at various stages pregnancy spontaneous studied activation AP-1 (c-Jun) NFκB (p65) systems, cytokine mRNA expression protein levels...
Abstract Background The role of omega-3 polyunsaturated fatty acids (n-3PUFA), and the potential impact n-3PUFA supplementation, in treatment management type 1 diabetes (T1D) remains unclear controversial. Therefore, this study aimed to examine efficacy daily high-dose-bolus supplementation on vascular health, glycaemic control, metabolic parameters subjects with T1D. Methods Twenty-seven adults T1D were recruited a 6-month randomised, double-blind, placebo-controlled trial. Subjects...