A5076688608- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Global Cancer Incidence and Screening
- Radiation Dose and Imaging
- Head and Neck Cancer Studies
- Advanced X-ray and CT Imaging
- Radiology practices and education
- Esophageal Cancer Research and Treatment
- HIV Research and Treatment
- Advanced Radiotherapy Techniques
- Medical Imaging and Pathology Studies
- Higher Education Learning Practices
- Autoimmune Bullous Skin Diseases
- Medical and Biological Sciences
- Advanced MRI Techniques and Applications
- Radiation Therapy and Dosimetry
- MRI in cancer diagnosis
- Theatre and Performance Studies
- Lymphadenopathy Diagnosis and Analysis
- Sarcoma Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Colorectal Cancer Screening and Detection
- HIV/AIDS Research and Interventions
Toronto General Hospital
2016-2024
University of Toronto
2016-2024
Sinai Health System
2017-2024
University Health Network
2016-2024
Cancer Care Ontario
2019-2024
UCLA Health
2024
Western University
2024
St. Michael's Hospital
2024
University of Kentucky
2022
Princess Margaret Cancer Centre
2016-2021
BackgroundCurrent lung cancer screening guidelines use either mean diameter, volume, or density of the largest nodule on previous CT scan appearance a new to ascertain timing next scan. We aimed develop an accurate protocol by estimating 3-year risk after two scans using deep learning radiologists' readings and other universally available clinical information.MethodsA algorithm (referred as DeepLR) was developed data from participants who had received at least up 2 years apart in National...
IntroductionLung cancer risk prediction models have the potential to make programs more affordable; however, economic evidence is limited.MethodsParticipants in National Lung Cancer Screening Trial (NLST) were retrospectively identified with tool developed from Prostate, Lung, Colorectal and Ovarian Trial. The high-risk subgroup was assessed for lung incidence demographic characteristics compared those low-risk Pan-Canadian Early Detection of Study (PanCan), which an observational study that...
In an analysis of data collected over a 10-year period from four emergency departments, short-term exposures to ambient heat and particulate air pollution were associated with increased utilization radiography CT but not US or MRI.
To investigate the role of lymphatic vessels and sinus system lymph node in spread HIV-1, we evaluated 15 nodes from patients with persistent generalized lymphadenopathy (PGL). Fifteen taken follicular hyperplasia not related to HIV-1 infection served as controls. Immunohistochemical situ hybridization techniques revealed infected cells within sinuses efferent lymphatics PGL nodes. In contrast, could be detected walls high endothelial venules nor areas immediately adjacent. The parenchymal...
The impact of lung cancer screening with low-dose chest CT (LDCT) on participants' anxiety levels and health-related quality life (HRQoL) is an important consideration in the implementation such programmes. We aimed to describe changes HRQoL a high-risk Canadian cohort undergoing LDCT screening.2537 subjects who had 2% or greater risk over 6 years using prediction tool were recruited from eight centres across Canada Pan-Canadian Early Detection Lung Cancer Study (2008-2010). compared before...
Purpose To assess the incidence of lung cancer in a cohort patients with negative findings at previous screening. Materials and Methods In this prospective study, authors first identified 4782 individuals who had screening results as part International Early Lung Cancer Action Program (1993–2005). Subjects were assigned risk score by using validated model. Starting those highest risk, subjects interviewed phone invited to undergo low-dose CT between March 2013 October 2016. diagnosis died...
Abstract RATIONALE: Appropriate management of low-dose computed tomography (LDCT) screening detected lung nodules will have significant implications for health care resource utilization and minimizing harm from radiation exposure related to imaging studies, invasive procedures clinically distress. OBJECTIVES We aimed to: provide a practical, evidence-based best practice framework healthcare professionals (HP) manage LDCT identify areas that require future studies. METHODS The Canadian...
Chronic obstructive pulmonary disease (COPD) is an underdiagnosed condition sharing risk factors with lung cancer. Lung cancer screening may provide opportunity to improve COPD diagnosis. Using Pan-Canadian Early Detection of Cancer (PanCan) study data, the present sought determine following: 1) What prevalence in a population? 2) Can model based on clinical and low-dose CT scan data predict likelihood COPD?The single arm PanCan recruited current or former smokers age 50-75 who had...
PURPOSE To improve outcomes for lung cancer through low-dose computed tomography (LDCT) early detection. The International Association the Study of Lung Cancer is developing Early Imaging Confederation (ELIC) to serve as an open-source, international, universally accessible environment analyze large collections quality-controlled LDCT images and associated biomedical data research routine screening care. METHODS ELIC international confederation that allows access efficiently numbers...
The MDM2 proto-oncogene encodes a 90-kDa protein that binds to and inactivates the tumor suppressor p53. Several reports describe presence of different alternatively, as well as, aberrantly spliced transcripts mRNA in variety human cancers have lost ability bind Due transforming at least some isoforms it has been suggested they might contribute tumorigenesis. Here we show shorter are also widely expressed normal tissues, including lung renal tissue, lymphocytes. Alteration RNA were found...