A5081524985- Lung Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Treatments and Mutations
- Economic and Financial Impacts of Cancer
- Esophageal Cancer Research and Treatment
- Health Policy Implementation Science
- Telemedicine and Telehealth Implementation
- Colorectal Cancer Screening and Detection
- Cell Adhesion Molecules Research
- Chemical Synthesis and Analysis
- Smoking Behavior and Cessation
- Acute Myeloid Leukemia Research
- Mental Health and Patient Involvement
- BRCA gene mutations in cancer
- Mental Health Treatment and Access
- Acute Lymphoblastic Leukemia research
- Treatment of Major Depression
- Global Health Care Issues
- Tryptophan and brain disorders
- Air Quality and Health Impacts
- Protein purification and stability
- Child and Adolescent Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- demographic modeling and climate adaptation
Simon Fraser University
2019-2025
University of British Columbia
2008-2024
Vancouver Coastal Health
2022-2024
Positive Living North
2023
Vancouver Coastal Health Research Institute
2022-2023
Fraser Health
2023
Cancer Council NSW
2023
The University of Sydney
2023
The George Institute for Global Health
2023
Université Paris Cité
2022
We report the design and total chemical synthesis of "synthetic erythropoiesis protein" (SEP), a 51-kilodalton protein-polymer construct consisting 166-amino-acid polypeptide chain two covalently attached, branched, monodisperse polymer moieties that are negatively charged. The ability to control chemistry allowed us synthesize macromolecule precisely defined covalent structure. SEP was homogeneous as shown by high-resolution analytical techniques, with mass 50,825 +/-10 daltons electrospray...
IntroductionLung cancer risk prediction models have the potential to make programs more affordable; however, economic evidence is limited.MethodsParticipants in National Lung Cancer Screening Trial (NLST) were retrospectively identified with tool developed from Prostate, Lung, Colorectal and Ovarian Trial. The high-risk subgroup was assessed for lung incidence demographic characteristics compared those low-risk Pan-Canadian Early Detection of Study (PanCan), which an observational study that...
Lung cancer is a major health problem. CT lung screening can reduce mortality through early diagnosis by at least 20%. Screening high-risk individuals most effective. Retrospective analyses suggest that identifying for accurate prediction models more efficient than using categorical age-smoking criteria, such as the US Preventive Services Task Force (USPSTF) criteria. This study prospectively compared effectiveness of USPSTF2013 and PLCOm2012 model eligibility
<h3>Background:</h3> Pharmacogenomic testing to identify variations in genes that influence metabolism of antidepressant medications can enhance efficacy and reduce adverse effects pharmacotherapy for major depressive disorder. We sought establish the cost-effectiveness implementing pharmacogenomic guide prescription antidepressants. <h3>Methods:</h3> developed a discrete-time microsimulation model care pathway disorder British Columbia, Canada, evaluate effectiveness from public payer's...
Rationale: The NLST (National Lung Screening Trial) reported a 20% reduction in lung cancer mortality with low-dose computed tomography screening; however, important questions on how to optimize screening remain, including which selection criteria are most accurate at detecting cancers and what nodule management protocol is efficient. PLCOm2012 (Prostate, Lung, Colorectal Ovarian) Cancer Trial 6-year PanCan (Pan-Canadian Early Detection of Cancer) malignancy risk models two the better...
It is estimated that millions of North Americans would qualify for lung cancer screening and billions dollars national health expenditures be required to support population-based computed tomography programs. The decision implement such programs should informed by data on resource utilization costs.Resource were collected prospectively from 2059 participants in the Pan-Canadian Early Detection Lung Cancer Study using low-dose (LDCT). Participants who had 2% or greater risk over 3 years a...
The impact of lung cancer screening with low-dose chest CT (LDCT) on participants' anxiety levels and health-related quality life (HRQoL) is an important consideration in the implementation such programmes. We aimed to describe changes HRQoL a high-risk Canadian cohort undergoing LDCT screening.2537 subjects who had 2% or greater risk over 6 years using prediction tool were recruited from eight centres across Canada Pan-Canadian Early Detection Lung Cancer Study (2008-2010). compared before...
Simulation models of smoking behaviour provide vital forecasts exposure to inform policy targets, estimates the burden disease, and impacts tobacco control interventions. A key element useful model-based is a clear picture uncertainty due data used model, however, assessment this parameter incomplete in almost all models. As remedy, we demonstrate Bayesian approach model calibration that quantifies uncertainty. With calibrated Australian data, observed cessation rate Australia has increased...
Scientific advances have led to the discovery of novel treatments with high prices. The cost publicly fund high-cost drugs may threaten sustainability drug budgets in different health care systems. In oncology, there are concerns that health-benefit gains diminishing over time and economic evidence support funding decisions is too limited.To assess additional costs benefits gained from oncology time, we used treatment protocols efficacy results U.S. Food Drug Administration records calculate...
The use of targeting ligands to enhance the delivery liposomal nanoparticles (LNs) has moved slowly toward clinical application. This relative lack progression is further complicated by existence conflicting in vivo results literature. In this work, we describe new formulations LNs that are targeted with an arginine-glycine-aspartic acid-containing peptide, cRGDfK, conjugated lipid distearoyl phosphatidylethanolamine (DSPE). These may be able circumvent some challenges encountered during...
The specific binding characteristics of αvβ3 integrins with an arginine-glycine-aspartic-acid (RGD) containing fluorescently labeled cyclic peptide is investigated capillary electrophoresis-frontal analysis method. new algorithm used to calculate the constants and stoichiometry was derived without assumptions made in commonly Scatchard Plot method, thus enabling determination parameters presence nonspecific binding. integrin, a membrane protein, studied solution, need immobilization or any...
A national, lung cancer screening programme is under consideration in Australia, and we assessed cost-effectiveness using updated data assumptions.We estimated the of by applying parameters outcomes from either National Lung Screening Trial (NLST) or NEderlands-Leuvens Longkanker Screenings ONderzoek (NELSON) to Australian on risk, mortality, health-system costs, smoking trends a deterministic, multi-cohort model. Incremental ratios (ICERs) were calculated for lifetime horizon.The ICER...
A 27-kDa TASP protein, T5Msc(103−151), that was derived from the cytoplasmic domain (amino acid residues 103−151) of MscL ion channel M. tuberculosis synthesized by ketoxime-forming chemoselective ligation between a template molecule carrying five pyruvic groups, and linear peptides one aminooxyacetic group. Ketoxime-forming provided for highly efficient assembly this large totally synthetic protein construct with yields >90% modest excess (1.5×) aminooxy peptide. Formation desired confirmed...
Acute Myeloid Leukaemia (AML) is a rare but serious group of diseases that require critical decision-making for curative treatment. Over the past decade, scientific discovery has revealed dozens prognostic gene mutations AML while sequencing costs have plummeted. In this study, we compared cost-effectiveness multigene integrative analysis (genomic analysis) with standard molecular testing currently used diagnosis intermediate-risk AML. We decision analytic model data and outcomes from...
Abstract Psychiatric genetic counseling (pGC) can improve patient empowerment and self‐efficacy. We explored the relationship between pGC psychiatric hospitalizations, for which no prior data exist. Using Population Data BC (a provincial dataset), we tested two hypotheses: (1) among patients (>18 years) with conditions who received May 2010 Dec 2016 ( N = 387), compared year pre‐pGC, in post‐pGC there would be fewer (a) individuals hospitalized (b) total hospital admissions; (2) using a...
Learning health systems (LHSs) embed social accountability into everyday workflows and can inform how governments build bridges across the digital divide.They shape partnerships using rapid cycles of data-driven learning to respond patients' calls action for equity from health.Adopting LHS approach involves re-distributing power, which is likely be met with resistance.We use example British Columbia's 811 services highlight infrastructure was created provide care answer questions about...
Background Prehospital telemedicine triage systems combined with machine learning (ML) methods have the potential to improve accuracy and safely redirect low-acuity patients from attending emergency department. However, research in prehospital settings is limited but needed; department overcrowding adverse patient outcomes are increasingly common. Objective In this scoping review, we sought characterize existing for ML-enhanced triage. order support future research, aimed delineate what data...
<h3>Background:</h3> Observational studies show that digital breast tomosynthesis (DBT) combined with mammography (DM) can reduce recall rates and increases of cancer detection. The objective this study was to examine the cost-effectiveness DBT plus DM versus alone in British Columbia identify parameters improve efficiency screening programs. <h3>Methods:</h3> We conducted an economic analysis based on data from a cohort participants BC Cancer Breast Screening Program. decision model...