A5101595396- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Historical Studies in Science
- History of Education in Spain
- Radiomics and Machine Learning in Medical Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Historical and socio-economic studies of Spain and related regions
- Airway Management and Intubation Techniques
- Epigenetics and DNA Methylation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Media, Journalism, and Communication History
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- RNA modifications and cancer
- Esophageal and GI Pathology
- Cystic Fibrosis Research Advances
- Asthma and respiratory diseases
- Esophageal Cancer Research and Treatment
- Advanced X-ray and CT Imaging
- Archaeological and Historical Studies
- Libraries, Manuscripts, and Books
- COVID-19 Clinical Research Studies
- Psychology Research and Bibliometrics
- Spanish History and Politics
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2019-2024
Hospital Universitari Germans Trias i Pujol
2001-2024
Universitat Autònoma de Barcelona
1997-2024
Barcelonaβeta Brain Research Center
2024
Instituto de Salud Carlos III
2015-2024
Hospital Universitario de La Princesa
2023
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2012-2022
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2012-2021
Clinica de Pneumologie Iaşi
2021
Bellvitge University Hospital
2009-2020
The lower airways of asymptomatic chronic obstructive pulmonary disease (COPD) patients can be colonized by bacteria, mainly Haemophilus influenza, Streptococcus pneumoniae, and Moraxella catarrhalis. However, the role airway bacteria in stable exacerbated COPD has not been well defined. To determine importance bacterial infection we studied 40 outpatients with (Group A: age 61.1 +/- 9.9 yr; [mean SD]; FEV1/FVC 51.7 12.5) 29 B: 63.4, SD 9.0 52.0, 9.6), using protected specimen brush (PSB)...
Background:The culture of bronchial secretions from the lower airway has been reported to be positive for potentially pathogenic microorganisms (PPMs) in patients with stable chronic obstructive pulmonary disease (COPD), but determinants and effects this bacterial load are not established. Methods:To determine microbial pattern COPD its relationship exacerbation, we pooled analysis crude data studies that used protected specimen brush sampling, age, sex, smoking, lung function, microbiologic...
Summary The interferon (IFN)‐γ component of the immune response plays an essential role in combating infectious and non‐infectious diseases. Induction IFN‐γ secretion by human T natural killer (NK) cells through synergistic costimulation with interleukin (IL)‐12 IL‐18 adaptive responses against pathogens is well established, but induction similar activity macrophages still controversial, doubts largely focusing on contamination NK or relevant experiments. possible contribution to IFN is,...
This multicentre, blinded, sham-controlled study was performed to assess the safety and effectiveness of bronchial valve therapy using a bilateral upper lobe treatment approach without goal lobar atelectasis. Patients with predominant severe emphysema were randomised bronchoscopy (n=37) or (n=36) IBV Valves for 3-month blinded phase. A positive responder defined as having both ≥4-point improvement in St George's Respiratory Questionnaire (SGRQ) volume shift measured by quantitative computed...
Abstract Purpose: Lung cancer remains as the leading cause of cancer-related death worldwide, mainly due to late diagnosis. Cytology is gold-standard method for lung diagnosis in minimally invasive respiratory samples, despite its low sensitivity. We aimed identify epigenetic biomarkers with clinical utility minimally/noninvasive specimens improve accuracy current technologies. Experimental Design: The identification novel stage I tumors was accomplished using an integrative genome-wide...
The aim of this study was to determine the prevalence and risk factors for lower airway bacterial colonization (LABC) in stable chronic bronchitis (CB). Forty-one outpatients with CB were enrolled (age 63.8+/-9.1 yrs (mean+/-SD); forced expiratory volume one second (FEV1)/forced vital capacity (FVC) 62.8+/-11.2; current/former smokers 24/17). All patients had normal chest radiographs an indication performing fibreoptic bronchoscopy (pulmonary nodule, remote haemoptysis). protected specimen...
Rationale: The NLST (National Lung Screening Trial) reported a 20% reduction in lung cancer mortality with low-dose computed tomography screening; however, important questions on how to optimize screening remain, including which selection criteria are most accurate at detecting cancers and what nodule management protocol is efficient. PLCOm2012 (Prostate, Lung, Colorectal Ovarian) Cancer Trial 6-year PanCan (Pan-Canadian Early Detection of Cancer) malignancy risk models two the better...
The changes in shield strategies, treatments, emergence variants, and healthcare pathways might shift the profile outcome of patients hospitalized with COVID-19 successive waves outbreak.
Over the past century rigid bronchoscopy has been established as main therapeutic means for central airway diseases of both benign and malignant aetiology. Its use requires general anaesthesia mechanical ventilation usually in form manual or high-frequency jet ventilation. Techniques applied to regain patency airways include debulking, thermal ablation (laser, electrocautery argon plasma coagulation) cryo-surgery. Each these techniques have their advantages limitations best results can be...
Objective: To describe the cohort of COPD patients monitored by Long-Term Home Non-Invasive mechanical ventilation (LTH-NIV), to evaluate economic impact intervention and determine existence clinical or ventilatory variables that are related success therapy.Methodology: Retrospective observational descriptive study with LTH-NIV telemonitoring between 2019 2022.Results: 68 were included, 73% male. Mean age 71 years. Emphysema 60.3% a mean obstruction 42.3%; comorbidity prevalence OSA was...
Mediastinal lymph node (LN) staging is routinely performed using PET/CT and EBUS-TBNA. Promising predictive algorithms for nodes have been reported each technique, both individually in combination. This study aims to develop a algorithm that combines EBUS, clinical data provide probability of malignancy. A retrospective was conducted on consecutive patients with non-small cell lung carcinoma staged Lymph were identified by level (N1, N2, N3) anatomical region (AR) (subcarinal, paratracheal,...
Summary During inflammation, interleukin (IL)-12 and IL-18 are produced by macrophages other cell types such as neutrophils (IL-12), keratinocytes damaged endothelial cells (IL-18). To explore the role of IL-12 in inflammatory innate immune responses we investigated their impact on human peripheral blood monocytes mature bronchoalveolar lavage (BAL) macrophages. together, but not alone, prevented spontaneous apoptosis cultured monocytes, promoted monocyte clustering subsequent...
<b><i>Background:</i></b> Airway stenting (AS) commenced in Europe circa 1987 with the first placement of a dedicated silicone airway stent. Subsequently, over last 3 decades, AS was spread throughout Europe, using different insertion techniques and types stents. <b><i>Objectives:</i></b> This study is an international survey conducted by European Association Bronchology Interventional Pulmonology (EABIP) focusing on practice within 26...
<b><i>Background:</i></b> Bronchoscopy is a safe technique for diagnosing peripheral pulmonary lesions (PPLs), and virtual bronchoscopic navigation (VBN) helps guide the bronchoscope to PPLs. <b><i>Objectives:</i></b> We aimed compare diagnostic yield of VBN-guided unguided ultrathin bronchoscopy (UTB) explore clinical technical factors associated with better results. developed algorithm deciding whether use VBN reach PPLs or choose an...
ABSTRACT Background and objective The relationship between IPF development environmental factors has not been completely elucidated. Analysing geographic regions of idiopathic pulmonary fibrosis (IPF) cases could help identify those areas with higher aggregation investigate potential triggers. We hypothesize that cross‐analysing location consistently high air pollution concentration lead to recognition risk for development. Methods This retrospective study analysed epidemiological clinical...
Invasive pulmonary aspergillosis (IPA) is a rare pathology with increasing incidence mainly in critical care settings and recently immunocompetent patients. The mortality of the disease very high, regardless an early diagnosis aggressive treatment. Here, we report case 56 yr old previously healthy woman who was found unconscious at home admitted to emergency room mild respiratory insufficiency. In first 24 hours she developed acute failure new radiographic infiltrates requiring Intensive...