A5083876511- COVID-19 Clinical Research Studies
- Transplantation: Methods and Outcomes
- COVID-19 and healthcare impacts
- Organ Transplantation Techniques and Outcomes
- Acute Kidney Injury Research
- Cardiac Arrest and Resuscitation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Transplantation Outcomes and Treatments
- Neuroscience and Neuropharmacology Research
- Mechanical Circulatory Support Devices
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Sepsis Diagnosis and Treatment
- Organ Donation and Transplantation
- Vasculitis and related conditions
- Sarcoidosis and Beryllium Toxicity Research
- Basque language and culture studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Antibiotic Use and Resistance
- Antifungal resistance and susceptibility
- Organizational Management and Innovation
- Nationalism and Cultural Identity
- Cardiac Fibrosis and Remodeling
- Lung Cancer Diagnosis and Treatment
Bellvitge University Hospital
2015-2025
Institut d'Investigació Biomédica de Bellvitge
2020-2023
Institut Català d'Oncologia
2020-2023
Universitat de Barcelona
2020-2021
Universitat de València
2021
VIB-UGent Center for Inflammation Research
2016
Institute of Molecular Biology and Biophysics
2016
Universidad Nacional Autónoma de México
1985-2008
Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased but their susceptibility structural valve degeneration (SVD) limits use in young patients. We hypothesized that antibodies against immunogenic glycans present on BHVs, particularly the xenoantigens galactose-α1,3-galactose (αGal) and N-glycolylneuraminic acid (Neu5Gc), could mediate deterioration through calcification. established a large longitudinal prospective international cohort of patients (n = 1668, 34 ±...
We wished to explore the use, diagnostic capability and outcomes of bronchoscopy added noninvasive testing in immunocompromised patients. In this setting, an inability identify cause acute hypoxaemic respiratory failure is associated with worse outcome. Every effort should be made obtain a diagnosis, either alone or combined bronchoscopy. However, our understanding risks benefits remains uncertain.This was pre-planned secondary analysis Efraim, prospective, multinational, observational study...
The utilization of non-lung organs from deceased donors with a positive polymerase chain reaction (PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the time donation can be lifesaving, although safety this policy must assessed.This is nationwide, prospective study, reporting experience on SARS-CoV-2-positive between December 15, 2020 and May 31, 2022 in Spain.A total 69 patients received solid organ transplant (41 kidney, 18 liver, 8 heart, combined liver-kidney)...
Abstract The Endothelial Activation and Stress Index (EASIX) is a laboratory-based prognosis index defined as creatinine × lactate dehydrogenase/platelets. When measured at pretransplantation evaluation (EASIX-PRE), it predicts allogeneic hematopoietic cell transplantation (alloHCT) mortality. This study explores its ability to predict intensive care unit (ICU) admission validates EASIX-PRE predictive power for overall survival (OS) nonrelapse mortality (NRM) in 167 consecutive patients...
Invasive pulmonary aspergillosis (IPA) is a rare pathology with increasing incidence mainly in critical care settings and recently immunocompetent patients. The mortality of the disease very high, regardless an early diagnosis aggressive treatment. Here, we report case 56 yr old previously healthy woman who was found unconscious at home admitted to emergency room mild respiratory insufficiency. In first 24 hours she developed acute failure new radiographic infiltrates requiring Intensive...
Granulomatosis with polyangiitis (GPA) is a small-vessel and medium-vessel vasculitis that affects mainly the respiratory tract kidney. The main acute complications of GPA are diffuse pulmonary hemorrhage renal failure. Renal involvement occurs in ∼17% patients, histological
The impact of Surviving Sepsis Campaign (SSC) care bundles in reducing sepsis-associated acute kidney injury (SA-AKI) was evaluated.We conducted an observational single-center cohort study. Accomplishment SSC registered all patients with severe sepsis admitted to the critical department a university hospital during three different periods. main outcome measured SA-AKI incidence defined as any worsening AKI stage within first 7 days from onset sepsis.Among 260 or septic shock finally meeting...
The NMDA (N-methyl-D-aspartate) receptors are important in the regulation of neuronal development, synaptic plasticity, learning and memory, involved several brain pathologies. NR1 subunit is essential for assembly functional receptors, as it forms calcium-permeable ion channel contains obligatory co-agonist binding site. Previous studies have shown that gene (Grin1) expression up-regulated during differentiation its widespread central nervous system. We previously cloned chicken Grin1 1.9...
Clinical outcomes of novel coronavirus 2019 disease (COVID-19) in onco-hematological patients are unknown. When compared to non-immunocompromised patients, seem have higher mortality rates.We describe the characteristics and a consecutive cohort 24 with COVID-19 during first month pandemic. We also variations healthcare resource utilization within our hematology department.Data from between pandemic were retrospectively collected. logistic data collected average values prior 3 months...
Thoracoabdominal (TA) normothermic regional perfusion (NRP) should allow the safe recovery of heart and liver grafts simultaneously in context controlled donation after circulatory death (cDCD). We present initial results cDCD transplantation with simultaneous procurement Spain until October 2021. Outcomes were compared a matched cohort abdominal NRP (A-NRP) from participating institutions. Primary endpoints comprised early allograft dysfunction (EAD) or primary non-function (PNF),...
Abstract Objectives Chimeric antigen receptor T cells (CARTs) against CD19 represent an effective therapy for relapsed/refractory diffuse large B‐cell lymphoma (rrDLBCL). There is no diagnostic test able to predict which patients with residual disease will relapse from those that reach a delayed complete response. Positron emission tomography/computed tomography scan (PET‐CT) characterized by significant number of false positive results after immunotherapy. Circulating tumor DNA (ctDNA) may...
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common postoperative complication, despite advances in surgical techniques and intensive care, mortality morbidity associated with renal failure have not markedly changed the last decade. Depending on definition used, incidence of CSA-AKI reported to range from 1 30%. requiring continuous replacement therapy (CRRT) occurs 1.2-3.0% cardiac surgery cohorts independently mortality.
Abstract Background Oncohematological patients, due to their secondary immunodeficiency, are at a higher risk of mortality related COVID-19 infection. Baricitinib, JAK2 inhibitor, has dual effect in this context, reducing the inflammatory response virus and diminishing endocytosis. Methods This phase I safety run-in cohort study aimed determine dose-limiting toxicity baricitinib terms rate serious events oncohematological patients with COVID-19. The drug was administered on an inpatient...