A5031834954- Respiratory Support and Mechanisms
- Vitamin C and Antioxidants Research
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Vitamin K Research Studies
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nutrition and Health in Aging
- Electrolyte and hormonal disorders
- Clinical Nutrition and Gastroenterology
- Climate Change and Health Impacts
- Blood transfusion and management
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal function and acid-base balance
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Cardiac, Anesthesia and Surgical Outcomes
- Therapeutic Uses of Natural Elements
- Vitamin D Research Studies
- Prostate Cancer Treatment and Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiovascular and Diving-Related Complications
- Neuroscience of respiration and sleep
- Nitric Oxide and Endothelin Effects
Amsterdam University Medical Centers
2018-2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2015-2024
Vrije Universiteit Amsterdam
2008-2024
St Thomas' Hospital
2022
King's College London
2022
University of Lübeck
2022
Heinrich Heine University Düsseldorf
2022
Philipps University of Marburg
2022
University of Münster
2022
October 6 University
2022
Rationale: The clinical significance of diaphragm weakness in critically ill patients is evident: it prolongs ventilator dependency, and increases morbidity duration hospital stay. To date, the nature its underlying pathophysiologic mechanisms are poorly understood.Objectives: We hypothesized that muscle fibers mechanically ventilated display atrophy contractile weakness, ubiquitin–proteasome pathway activated diaphragm.Methods: obtained biopsies from 22 who received mechanical ventilation...
BackgroundTrace elements and vitamins, named together micronutrients (MNs), are essential for human metabolism. The importance of MNs in common pathologies is recognized by recent research, with deficiencies significantly impacting the outcome.ObjectiveThis short version guideline aims to provide practical recommendations clinical practice.MethodsAn extensive search literature was conducted databases Medline, PubMed, Cochrane, Google Scholar, CINAHL initial guideline. focused on...
PURPOSE: N-Benzoyl staurosporine (PKC412) is a protein kinase C inhibitor with antitumor activity in laboratory models. We determined the toxicity of oral PKC412 administered daily for repeat cycles 28 days. PATIENTS AND METHODS: Thirty-two patients advanced solid cancers were treated at seven dose levels (12.5 to 300 mg daily) total 68 cycles. RESULTS: The most frequent treatment-related toxicities nausea, vomiting, fatigue, and diarrhea. At two top (225 mg/d), 15 16 experienced...
Prophylactic use of fresh-frozen plasma (FFP) is common practice in patients with a coagulopathy undergoing an invasive procedure. Evidence that FFP prevents bleeding lacking, while risks transfusion-related morbidity after have been well demonstrated. We aimed to assess whether omitting prophylactic transfusion nonbleeding critically ill who undergo intervention noninferior FFP.A multicenter randomized open-label trial blinded endpoint evaluation was performed prolonged international...
Hyperoxemia may increase organ dysfunction in critically ill patients, but optimal oxygenation targets are unknown.To determine whether a low-normal Pao2 target compared with high-normal reduces patients systemic inflammatory response syndrome (SIRS).Multicenter randomized clinical trial 4 intensive care units the Netherlands. Enrollment was from February 2015 to October 2018, end of follow-up January 2019, and included adult admitted 2 or more SIRS criteria expected stay longer than 48...
Monitoring and controlling lung stress diaphragm effort has been hypothesized to limit injury injury. The occluded inspiratory airway pressure (Pocc) the occlusion at 100 ms (P0.1) have used as noninvasive methods assess respiratory muscle effort, but comparative performance of these measures their correlation is unknown. authors that Pocc P0.1 correlate with would strong discriminative in identifying extremes effort.Change transdiaphragmatic transpulmonary was obtained double-balloon...
Abstract Introduction Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion systemic inflammation and endothelial damage. Adverse effects FFP have been well described, including acute lung injury. However, it is also suggested that higher amount decreases mortality in trauma patients requiring massive transfusion. Furthermore, has an stabilizing experimental models. We investigated condition. Methods A prospective predefined substudy randomized trial coagulopathic...
Rationale: Diaphragm weakness in critically ill patients prolongs ventilator dependency and duration of hospital stay increases mortality healthcare costs. The mechanisms underlying diaphragm include cross-sectional fiber atrophy contractile protein dysfunction, but whether additional are at play is unknown.Objectives: To test the hypothesis that mechanical ventilation with positive end-expiratory pressure (PEEP) induces longitudinal by displacing caudal direction reducing length...
Background Acute kidney injury (AKI) complicates shock. Diagnosis is based on rising creatinine, a late phenomenon. Intrarenal vasoconstriction occurs earlier. Measuring flow resistance in the renal circulation, Renal Resistive Index (RRI), could become part of vital organ function assessment using Doppler ultrasound. Our aim was to determine whether RRI ICU admission an early predictor and discriminator AKI developed within first week. Methods In this prospective cohort mixed patients with...
We wished to explore the use, diagnostic capability and outcomes of bronchoscopy added noninvasive testing in immunocompromised patients. In this setting, an inability identify cause acute hypoxaemic respiratory failure is associated with worse outcome. Every effort should be made obtain a diagnosis, either alone or combined bronchoscopy. However, our understanding risks benefits remains uncertain.This was pre-planned secondary analysis Efraim, prospective, multinational, observational study...
Positive end-expiratory pressure (PEEP) is routinely applied in mechanically ventilated patients to improve gas exchange and respiratory mechanics by increasing lung volume (EELV). In a recent experimental study rats, we demonstrated that prolonged application of PEEP causes diaphragm remodeling, especially longitudinal muscle fiber atrophy. This potential clinical importance, as the acute withdrawal during ventilator weaning decreases EELV thereby stretches adapted, longitudinally atrophied...