A5025868520- Anesthesia and Sedative Agents
- Trauma and Emergency Care Studies
- Anesthesia and Pain Management
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Trauma Management and Diagnosis
- Cardiac Arrest and Resuscitation
- Abdominal Surgery and Complications
- Intensive Care Unit Cognitive Disorders
- Pleural and Pulmonary Diseases
- Spinal Fractures and Fixation Techniques
- Disaster Response and Management
- Enhanced Recovery After Surgery
- Venous Thromboembolism Diagnosis and Management
- Pharmacological Effects and Toxicity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Spine and Intervertebral Disc Pathology
- Restraint-Related Deaths
- Pain Management and Treatment
- Pituitary Gland Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Hemodynamic Monitoring and Therapy
Radboud University Nijmegen
2019-2025
Radboud University Medical Center
2019-2025
Christ University
2023
University Medical Center
2022
Toronto Western Hospital
2021
Imelda Hospital
2021
Canisius-Wilhelmina Ziekenhuis
2019
Amsterdam UMC Location University of Amsterdam
2012
University of Amsterdam
2012
The Netherlands Cancer Institute
2006-2009
Positive end-expiratory pressure (PEEP) is routinely applied in mechanically ventilated patients to improve gas exchange and respiratory mechanics by increasing lung volume (EELV). In a recent experimental study rats, we demonstrated that prolonged application of PEEP causes diaphragm remodeling, especially longitudinal muscle fiber atrophy. This potential clinical importance, as the acute withdrawal during ventilator weaning decreases EELV thereby stretches adapted, longitudinally atrophied...
Objective: To study the effects of intra-abdominal pressure on quality recovery and innate cytokine production capacity after laparoscopic colorectal surgery within enhanced program. Background: There is increasing evidence for safety advantages low-pressure pneumoperitoneum facilitated by deep neuromuscular blockade (NMB). Nonetheless, there a weak understanding relationship between clinical outcomes, surgical injury, postoperative immune dysfunction, infectious complications. Methods:...
Increasing evidence shows that postoperative innate immune dysregulation is associated with delayed recovery and infectious complications. The aim of this study was to compare the effects general versus spinal anesthesia on function during after total hip arthroplasty (THA). This comparative matched cohort used data from two single-center randomized-controlled trials. Patients control group HIPPO received were patients MAGIC who in a 2:1 ratio (general(n = 18); spinal(n 9)). Immune assessed...
Postoperative immunosuppression is a well known phenomenon associated with infectious complications. Peri-operative immune dysregulation likely induced by surgical damage and anaesthetics, but remains far from comprehensively characterised. To address this, the effects of individual drugs on function must be explored. Sugammadex, cyclodextrin that encapsulates rocuronium, also binds other structures may influence inflammatory response. Investigate potential immunomodulatory effect...
In Brief BACKGROUND: Many supralaryngeal airway devices are available. Because of the absence an inflatable cuff, we hypothesized that use i-gel® should produce fewer postoperative throat and neck complaints compared with a standard disposable laryngeal mask (LM). METHODS: Two hundred eighteen patients were randomized to have either i-gel or La Premiere® LM placed for management. Patients interviewed postoperatively at 1, 24, 48 h. Interviewers blinded device used. RESULTS: One nine had 103...
Objective Previous studies identified different typologies of role models (as teacher/supervisor, physician and person) explored which faculty's characteristics could distinguish good models. The aim this study was to explore how extent clinical teaching performance influences residents' evaluations modelling statuses, especially across specialties. Methods In a prospective multicenter multispecialty performance, we used web-based questionnaires gather empirical data from residents. main...
Abstract Background Breast cancer is the second most common cause of death from in women worldwide. Counterintuitively, large population-based retrospective trials report better survival after breast-conserving surgery (BCS) compared to mastectomy, corrected for tumour- and patient variables. More extensive surgical tissue injury activation sympathetic nervous system by nociceptive stimuli are associated with immune suppression. We hypothesized that mastectomy causes a higher expression...
To compare the effectiveness of low intra-abdominal pressure (IAP) facilitated by deep neuromuscular block (NMB) to standard practice in improving quality recovery, preserving immune function, and enhancing parietal perfusion during robot-assisted radical prostatectomy (RARP).
Background Increasing evidence supports a positive relationship between the intensity of early postoperative pain, and risk 30-day complications. Higher pain levels may hamper recovery contribute to immunosuppression after surgery. This leaves patients at Methods One thousand who underwent major abdominal surgery (cytoreductive hyperthermic intraperitoneal chemotherapy, esophageal, liver, or pancreas surgery) Radboud university medical center were randomly selected from eligible 2014 2020....
Background: The degradation of sevoflurane can lead to the production compound A (CA) and carbon monoxide (CO) an increase in temperature absorbent. CA is known be nephrotoxic rats. These reactions depend on strong base water contents dioxide absorbent used. purpose this study was measure maximum amounts CO produced, increase, for seven different absorbents containing bases. Methods: Seven [some free bases (f)] were employed hydrated (h) completely desiccated (d) conditions a patient model,...
Summary Recently, we described an adaptation of awake fibreoptic intubation that call fibrecapnic intubation. The aim this study was to evaluate the efficacy and risk complications with novel technique in a consecutive case series head neck cancer patients known have difficult airways. We prospectively studied 40 intubations prior diagnostic or surgical procedure. Following topical anaesthesia, flexible bronchoscope introduced into pharynx; spontaneous respiration maintained all patients. A...
Conflicting data exist regarding the effects of deep neuromuscular blockade (NMB) on abdominal dimensions during laparoscopic procedures. We performed a clinical study to establish influence moderate and working space, measured by Magnetic Resonance Imaging (MRI), donor nephrectomy with standard pressure (12 mmHg) pneumoperitoneum under sevoflurane anaesthesia.Ten patients were intraoperatively scanned three times in lateral decubitus position, maintained mobile insufflator. The first scan...
Residual neuromuscular blockade (rNMB) remains a persistent and preventable problem, with serious risks.
Abstract The validity with respect to presence or absence of CRPS I according Veldman's criteria was assessed for measured pain, temperature, volume differences and limitations in range motion. Evaluated were 155 assessments 66 outpatients, initially diagnosed I, but many them not so on follow up visits. Pain VAS McGill, temperature by infrared thermometry, water displacement volumeters motion universal goniometers. Sensitivity, specificity, positive negative predictive value the measurement...
BACKGROUND: Desflurane and enflurane have been reported to produce substantial amounts of carbon monoxide (CO) in desiccated sodalime. Isoflurane is said less CO sevoflurane halothane should no at all.The purpose this study measure the maximum production for all modern volatile anesthetics, with completely dry We also tried establish a relationship between temperature increase inside METHODS: A patient model was simulated using circle anesthesia system connected an artificial lung....
Abstract Our research group recently published a positive association between early postoperative pain and 30-day complications in broad surgical population. To investigate whether heterogeneity of the population procedures influenced these results, we explored this homogenous A secondary analysis LEOPARD-2 (clinicaltrials.gov NCT02146417) RELAX-1 study (NCT02838134) laparoscopic donor nephrectomy patients (n = 160) was performed. Pain scores on postanesthesia care unit day (POD) 1 2 were...
Abstract Background Minimally invasive adrenalectomy is the standard of care for small adrenal tumours. Both transperitoneal lateral approach and posterior retroperitoneal are widely used have been proven to be safe effective. However, prevalence chronic postsurgical pain has not specifically investigated in previous studies. The primary goal this study was identify after minimally adrenalectomy. Methods A cross-sectional performed among all consecutive patients who had undergone a single...
Background: Desflurane is known to produce high concentrations of carbon monoxide (CO) in desiccated sodalime or Baralyme ® (Allied Healthcare Products, St. Louis, MO). Desiccated absorbents without strong bases like potassium hydroxide sodium are reported less no CO at all. The purpose this study compare the concentration an anesthesia circuit for desflurane with six different types completely 2 than sodalime. Methods: A patient model was simulated using a circle system connected artificial...
The patient-ventilator breath contribution (PVBC) index estimates the relative of patient to total tidal volume (Vt insp ) during mechanical ventilation in neurally adjusted ventilator assist mode and has been used titrate support. reliability this ventilated patients is unknown was investigated study. PVBC calculated by comparing diaphragm electrical activity (EAdi) assisted breaths /EAdi) unassisted no-assist . Vt normalized peak EAdi (EAdi using 1) one breath, 2) five consecutive breaths,...
There is accumulating evidence that deep neuromuscular blockade (NMB) improves intraoperative surgical conditions during laparoscopic surgery. Studies investigating the effects of NMB in open surgery are scarce. In theory, by limiting damage through deeper muscle relaxation, postoperative inflammation and concomitant immune suppression can be reduced. Therefore, this study will investigate total hip arthroplasty, which demands a relatively large exposure joint between muscles.This monocentre...