A5017531203- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Nitric Oxide and Endothelin Effects
- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- High Altitude and Hypoxia
- Vitamin K Research Studies
- Hemodynamic Monitoring and Therapy
- Vitamin C and Antioxidants Research
- Climate Change and Health Impacts
- Cardiovascular and Diving-Related Complications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intensive Care Unit Cognitive Disorders
- Systemic Lupus Erythematosus Research
- Science and Climate Studies
- COVID-19 and healthcare impacts
- Mechanical Circulatory Support Devices
- Neurosurgical Procedures and Complications
- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Bacterial Identification and Susceptibility Testing
- Eicosanoids and Hypertension Pharmacology
- Hematological disorders and diagnostics
- Neuroscience of respiration and sleep
University Medical Center Utrecht
2023
Haga Hospital
2020-2021
Amsterdam University Medical Centers
2021
Amsterdam UMC Location Vrije Universiteit Amsterdam
2013-2019
Vrije Universiteit Amsterdam
2019
Amsterdam UMC Location University of Amsterdam
2017
Erasmus MC
2017
Hyperoxemia may increase organ dysfunction in critically ill patients, but optimal oxygenation targets are unknown.To determine whether a low-normal Pao2 target compared with high-normal reduces patients systemic inflammatory response syndrome (SIRS).Multicenter randomized clinical trial 4 intensive care units the Netherlands. Enrollment was from February 2015 to October 2018, end of follow-up January 2019, and included adult admitted 2 or more SIRS criteria expected stay longer than 48...
Abstract Background The safety of perioperative hyperoxia is currently unclear. Previous studies in patients undergoing coronary artery bypass surgery suggest reduced myocardial damage when avoiding extreme (>400 mmHg). In this study we investigated whether an oxygenation strategy from moderate to a near-physiological oxygen tension reduces and improves haemodynamics, organ dysfunction oxidative stress. Methods This was single-blind, single-centre, open-label, randomised controlled trial...
Hyperoxia, an arterial oxygen pressure of more than 100 mmHg or 13% O2, frequently occurs in hospitalized patients due to administration supplemental oxygen. Increasing evidence suggests that hyperoxia induces vasoconstriction the systemic (micro)circulation, potentially affecting organ perfusion. This study addresses effects on viability, proliferative capacity, and pathways vascular tone cultured human microvascular endothelial cells (hMVEC).hMVEC circulation were exposed graded fractions...
Vitamin C deficiency is common in critically ill patients. C, the most important antioxidant, likely consumed during oxidative stress and associated with organ dysfunction mortality. Assessment of vitamin status may be to identify patients who might benefit from administration. Up now, concentrations are not available daily clinical practice. Recently, a point-of-care device has been developed that measures static oxidation-reduction potential (sORP), reflecting stress, antioxidant capacity...
In spite of the introduction mild therapeutic hypothermia (MTH), mortality rates remain high in patients with return spontaneous circulation (ROSC) after cardiac arrest (CA). To date, no accurate and independent biomarker to predict survival these exists. B-type natriuretic peptide (BNP) was found provide both prognostic diagnostic value various cardiovascular diseases, including hospital discharge ROSC. However, biologically inactive counterpart BNP, NT-proBNP, be a more stable analyte. The...
Abstract Objective To determine the human dose‐response relationship between a stepwise increase in arterial oxygen tension and its associated changes DO 2 sublingual microcirculatory perfusion. Methods Fifteen healthy volunteers breathed increasing fractions for 10 minutes to reach tensions of baseline (breathing air), 20, 40, 60 kPa, max kP oxygen). Systemic hemodynamics were measured continuously by volume‐clamp method. At end each period, microcirculation was assessed SDF. Results...
Hospitalized patients often receive oxygen supplementation, which can lead to a supraphysiological tension (hyperoxia). Hyperoxia have hemodynamic effects, including an increase in systemic vascular resistance. This suggests hyperoxia-induced vasoconstriction, yet reported direct effects of hyperoxia on vessel tone been inconsistent. Furthermore, changes diameter not studied mice, currently the most used mammal model disease. In this study we set out develop pressure-myograph using isolated...
Abstract Background Hypovitaminosis C and vitamin deficiency are common in critically ill patients associated with organ dysfunction. Low status often goes unnoticed because determination is challenging. The static oxidation reduction potential (sORP) reflects the amount of oxidative stress blood a suitable surrogate marker for C. sORP can be measured rapidly using RedoxSYS system, point-of-care device. This study aims to validate model that estimates plasma concentration determine...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Tusscher BL, Gudden C, Vliet SV, et al. Focus on focus: lack of coherence between systemic and microvascular indices oedema formation. Anaesthesiology Intensive Therapy. 2017;49(5). APA Tusscher, B. L., Gudden, C., Vliet, S. V., Smit, B., Ince, & Boerma, E. C. (2017). Therapy, 49(5). Chicago Birkitt L, Corien Suus V Bob Can C Harm-Jan S Grooth 2017. "Focus formation". Therapy 49 (5). Harvard S., E., Grooth, H.,...
Oxidative stress is an important part of a wide range pathologies and therefore interesting parameter to determine. However, the detection reactive oxygen species (ROS), not straightforward. Sample heterogeneity, delayed analysis sample preparation, reduces specificity sensitivity due probe activation by light, air, leakage from cells or cellular manipulation. Hence, samples should be processed minimally analysed immediately if possible. Since clinical research can subject uncontrollable...
Hyperoxia is frequently encountered in the intensive care unit (ICU) and during surgical procedures such as coronary artery bypass surgery (CABG). Higher oxygen concentrations intuitively provide a salutary reserve, but hyperoxia can induce adverse effects systemic vasoconstriction, reduction of cardiac output, increased microcirculatory heterogeneity reactive species production. Previous studies patients undergoing CABG suggest reduced myocardial damage when avoiding extreme perioperative...
Even though routine screening of the general hospital population is discouraged, medical laboratories may use a "lupus sensitive" activated partial thromboplastin time test (aPTT) with phospholipid concentrations that are susceptible to inhibition by lupus anticoagulant (LA), screen for presence LA. If deemed necessary, follow-up testing according ISTH guidelines be performed. However, LA laborious and time-consuming effort often not readily available due lack automation and/or temporary...
Introduction: Despite the apparent appropriateness of mild therapeutic hypothermia (MTH) to limit neurological injury and improve survival in patients with return spontaneous circulation (ROSC) after cardiac arrest (CA), mortality rates remain high. To date, no accurate independent biomarker predict these exists. B-type natriuretic peptide (BNP) was found provide both prognostic diagnostic value various cardiovascular diseases. However, biologically inactive counterpart BNP, NT-proBNP, be...
Summary Background Due to the large number of patients with coronavirus disease 19 (COVID-19), rapid diagnosis at emergency department (ED) is critical importance. In this study we have developed a flowchart based on two well-known diagnostic methods: ‘corona-score’ and ‘CO-RADS’. This can be used in hospitals that use chest-CT, instead chest X-ray, for COVID-19 suspected ED. Methods ED (n=1904) from Jeroen Bosch Hospital, Amphia HagaHospital, Elisabeth TweeSteden Bernhoven Hospital...