A5021193644- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic aneurysm repair treatments
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Water-Energy-Food Nexus Studies
- Hip and Femur Fractures
- Infectious Aortic and Vascular Conditions
- Platelet Disorders and Treatments
- Cardiomyopathy and Myosin Studies
- Venous Thromboembolism Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Heparin-Induced Thrombocytopenia and Thrombosis
- Lipoproteins and Cardiovascular Health
- Photovoltaic Systems and Sustainability
- Ultrasound in Clinical Applications
- Blood groups and transfusion
- Transplantation: Methods and Outcomes
- Global Health Care Issues
- Pulmonary Hypertension Research and Treatments
- Congenital heart defects research
- Biological Stains and Phytochemicals
- Organ Transplantation Techniques and Outcomes
Institut du Thorax
2018-2025
Nantes Université
2019-2024
Centre National de la Recherche Scientifique
2023-2024
Inserm
2018-2024
Laboratoire de l'Atmosphère et des Cyclones
2018-2024
Centre Hospitalier Universitaire de Nantes
2018-2024
Université Paris-Saclay
2024
Hôpital Marie Lannelongue
2024
Hôpital Laennec
2021
Centre Hospitalier Universitaire de Rennes
2018
Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased but their susceptibility structural valve degeneration (SVD) limits use in young patients. We hypothesized that antibodies against immunogenic glycans present on BHVs, particularly the xenoantigens galactose-α1,3-galactose (αGal) and N-glycolylneuraminic acid (Neu5Gc), could mediate deterioration through calcification. established a large longitudinal prospective international cohort of patients (n = 1668, 34 ±...
Abstract OBJECTIVES This study provides a thorough analysis of cardiac surgeons' involvement in transcatheter aortic valve replacement (TAVR) activities France, covering decision-making, procedural roles, training, and outcome analysis. METHODS A nationwide survey was sent to all surgeons surgery trainees France. Subgroup performed for age, status (established versus in-training), type practice facility. RESULTS total 172 from both private public sectors responded the survey. Most...
Extracorporeal membrane oxygenation (ECMO) is an accepted and reliable technique to provide temporary circulatory and/or respiratory support. Our objective was describe the transfusion requirements in ECMO recipients. Secondarily, we addressed effect of indications for on baseline factors associated with worse survival.We reviewed prospectively collected data 509 patients receiving venoarterial (VA) or venovenous (VV) therapy (2005-2016). Follow-up conducted. Data were entered Rennes...
The carotid approach for transcatheter aortic valve replacement (TAVR) has been shown to be feasible and safe. goal of this study was compare the 30-day outcomes trans-carotid (TC) transfemoral (TF) TAVR.This retrospective enrolled 500 consecutive patients treated by TC-TAVR (n = 100) or TF-TAVR 400) with percutaneous closure between January 2018 2020 at Nantes University Hospital. primary end-point occurrence cardiovascular death cerebrovascular events 30 days.The mean age 79.9 ± 8.1 in TC...
Objectives: This study assesses the feasibility of acute type A dissections treatment with a dedicated aortic root endograft concept and introduces new classification. Summary Background Data: Acute dissection (ATAAD) remains catastrophic condition perioperative mortality ranging from 12% 20%. Total Aortic endovascular repair, “Endobentall concept”, has been explored as an alternative but only documented on case report. Methods: Imaging all consecutive patients treated in three French...
Abstract Acute aortic syndromes (AAS) have been related to significant circadian and seasonal conditions. We used time series analyses study the impact of meteorological variations on AAS occurrence. retrospectively assessed 140 patients presenting with over a 6-year period in French university hospital. Average daily temperature (T) atmospheric pressure (AP) at location event were collected within previous 10 days, their association investigated generalized additive models. A decrease more...
A simplified delivery technique for the frozen elephant trunk procedure allows distal suture to be performed on a perfused and loaded aorta in moderate hypothermia—or even normothermia—reducing circulatory arrest time just few minutes. Two surgical sealing tourniquets are placed around aortic arch, usually between brachiocephalic (BCT) left common carotid artery is cross-clamped cardioplegia started. Once mild hypothermia, BCT disconnected initiated while cerebral perfusion maintained. This...
Purpose: Spinal cord injury (SCI) is a devastating complication of thoracoabdominal aortic (TAA) repair. The use prophylactic cerebrospinal fluid drainage (CSFD) as part protective protocol during endovascular repair controversial. This article reports the results CSFD prevention implemented in 2016. Methods: Retrospective review spinal outcomes (SCI rate and CSFD-related complications) patients treated endovascularly for TAA disease at single institution from 2016 (implementation an...
Background: Thrombocytopenia is a common disorder after heart or lung transplantation. Platelet transfusion often required to maintain haemostasis but represents specific cause of morbidity and mortality in this setting including alloimmunisation graft rejection. Study design methods: As part health-care quality improvement project, single-centre before–after pilot study, the relevance platelet saving strategy based on romiplostim administration transplantation was assessed patients with...
Transcatheter aortic valve replacement is currently used off-label for noncalcified regurgitation and therefore restricted to selected cases. In this setting we describe a rare complication of Sapien 3 (Edwards Lifesciences, Irvine, California) embolization from the left ventricle descending aorta. Given their technical challenges, such procedures require specific considerations management. (Level Difficulty: Advanced.)
To evaluate the long-term results of implantation homogeneous large size pulmonary homograft (PH) for reconstruction right ventricular outflow tract (RVOT).Between January 2000 and December 2017, 107 patients were implanted with PH RVOT. Data collected retrospectively in this single-center study. failure was defined as a peak gradient greater than 40 mmHg and/or regurgitation Grade 2. Primary endpoint reoperation RVOT during follow-up. Secondary endpoints overall survival, occurrence rate...
Bartonella species represent important causative agents of blood culture-negative infective endocarditis (IE). Their diagnosis represents a challenge for microbiologists and often relies on serological molecular tools. However, even if the sensitivity culture remains low, it should not be definitely ruled out. Indeed, we report unusual case 22 year-old Guinean homeless man diagnosed with an IE due to quintana. Unexpectedly, conventional cultures were positive after 13 days incubation....
Aortic valve calcification (AVC) of surgical bioprostheses (BPs) has been poorly explored. We aimed to evaluate in vivo and ex BP AVCs its prognosis value.
Abstract Background The use of biological heart valves (BHV) is constantly growing for the treatment patients with aortic stenosis and their durability arises as a main concern in field. Structural valve deterioration (SVD) BHV occurs gradually post-implantation seems to reiterate, at least part, pathophysiological processes described native stenosis. Lipoprotein (a) [Lp(a)] an important genetically determine cardiovascular risk factors, associated calcification. shorter polymorphic sizes...