A5069084412- Blood Pressure and Hypertension Studies
- Aortic aneurysm repair treatments
- Renal and Vascular Pathologies
- Aortic Disease and Treatment Approaches
- Healthcare Systems and Practices
- Cardiovascular Health and Disease Prevention
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Obstructive Sleep Apnea Research
- Peripheral Artery Disease Management
- Heart Rate Variability and Autonomic Control
- Acute Myocardial Infarction Research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular and Diving-Related Complications
- Hemodynamic Monitoring and Therapy
- Cardiovascular Issues in Pregnancy
- Pregnancy and preeclampsia studies
- Acute Ischemic Stroke Management
- Hormonal Regulation and Hypertension
- Cardiovascular Disease and Adiposity
- Cardiovascular and exercise physiology
- Heart Failure Treatment and Management
- Sodium Intake and Health
- Health, Medicine and Society
Institut Pasteur de Lille
2018-2023
Centre Hospitalier Universitaire de Lille
2014-2023
Société Française de Médecine Vasculaire
2009-2023
Université de Lille
2009-2023
Inserm
2011-2023
Radiance Technologies (United States)
2022-2023
Université Sorbonne Paris Nord
2016-2021
IMPact de l'Environnement Chimique sur la Santé humaine
2019
Lille’s Cardiology Hospital
2009-2018
Hôpital Européen Georges-Pompidou
2016-2017
Background: The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressure–lowering efficacy of renal denervation added to a standardized stepped-care antihypertensive treatment resistant hypertension at 6 months. We report influence adherence on pressure control. Methods: One hundred six patients with 4 weeks indapamide 1.5 mg/d, ramipril 10 mg/d (or irbesartan 300 mg/d), and amlodipine were randomly assigned plus treatment, or same alone. For spironolactone 25...
[Figure: see text].
Functional renal impairment is a common feature of heart failure with preserved ejection fraction (HFpEF). The link between functional and HFpEF remains incompletely understood. With hypertension diabetes as frequent co-morbidities, patients are at risk developing intra-renal vascular hemodynamic alterations that may lead to impact on prognosis.Renal resistive index (RRI) was non-invasively determined by Doppler ultrasonic examination in 90 age- sex-matched hypertensive without evidence (HF)...
<h3>Importance</h3> Modern data regarding incidence and modes of death patients with aortic stenosis (AS) are restricted to tertiary centers or studies valve replacement (AVR). <h3>Objective</h3> To provide new insights into the natural history outpatients native AS based on a large regionwide population study inclusion by all cardiologists regardless their mode practice. <h3>Design, Setting, Participants</h3> Between May 2016 December 2017, consecutive mild (peak velocity, 2.5-2.9 m/s),...
The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressure (BP) lowering efficacy of renal denervation added to a standardized stepped-care antihypertensive treatment resistant hypertension at 6 months. We report here effect on 24-hour BP and its variability look parameters that predicted response. Patients with were randomly assigned plus or alone (control). Average standard deviation 24-hour, daytime, nighttime smoothness index calculated recordings performed...
We conducted a pilot multicenter double-blind randomized placebo-controlled crossover pharmacodynamic study to evaluate the blood pressure (BP) and hormonal effects of firibastat, first-in-class aminopeptidase A inhibitor prodrug, in patients with hypertension. Thirty-four daytime ambulatory BP at least 135/85 mmHg less than 170/105 mmHg, after 2-week run-in period were randomly assigned receive either firibastat (250 mg b.i.d. for 1 week uptitrated 500 3 weeks) then placebo 4 weeks each or...
PurposeTo evaluate contrast-enhanced ultrasound (CEUS) as an effective alternative to computed tomographic angiography (CTA) during follow-up after fenestrated endovascular aneurysm repair (EVAR) of juxtarenal aortic aneurysms. MethodsBetween January 2008 and April 2011, 62 patients (all men; mean age 72 years) underwent EVAR with both CTA CEUS. In a retrospective analysis, the first CEUS postoperative examinations were compared for endoleak detection, sac diameter, target vessel patency....
Background The DENERHTN (Renal Denervation for Hypertension) trial confirmed the efficacy of renal denervation (RDN) in lowering daytime ambulatory systolic blood pressure when added to standardized stepped‐care antihypertensive treatment (SSAHT) resistant hypertension at 6 months. Methods and Results This post hoc exploratory analysis assessed impact abdominal aortic calcifications (AAC) on hemodynamic response RDN In total, 106 patients with were randomly assigned plus SSAHT or same alone...
To compare the clinical significance of exercise echocardiography (ExE) and cardiopulmonary testing (CPX) in patients with ≥moderate primary mitral regurgitation (MR) discrepancy between symptoms MR severity.Patients consulting for discordant prospectively underwent low (25 W) ExE, peak CPX within 2 months Lille Rennes University Hospital. Patients Class I recommendation surgical correction were excluded. Changes severity, systolic pulmonary artery pressure (SPAP), left ventricular ejection...
Although recommendations encourage daily moderate activities in post aortic dissection, very little data exists regarding cardiopulmonary exercise testing (CPET) to personalize those patient's physical rehabilitation and assess their cardiovascular prognosis.We aimed at the prognostic insight of CPET events by exploring a prospective cohort patients followed-up after acute dissection.Patients referred our department an (type A or B) dissection were prospectively included between September...
The renal resistive index has been demonstrated to predict the progression of disease and recurrence major cardiac events in high-risk cardiovascular patients, addition other comorbidities. We aimed assess prognostic significance type 2 diabetic patients for primary prevention. From 2008 2011, with diabetes underwent evaluation, including assessment by Doppler ultrasound. incidence all-cause death, events, dialysis requirement or a twofold increase creatinine was recorded. Survival curves...
Abstract Whether arterial stiffness is a surrogate end-point for cardiovascular and renal disease has never been directly demonstrated by controlled clinical trial. Our main hypothesis better prevention of outcomes in high risk hypertensives with PWV normalization driven strategy than usual blood pressure therapeutic based on European Society Hypertension—European Cardiology (ESH—ESC) guidelines. The preventing events study multicenter open-label randomized trial blinded endpoint evaluation...
Objective Current data regarding the impact of diabetes mellitus (DM) on cardiovascular mortality in patients with aortic stenosis (AS) are restricted to severe AS or valve replacement (AVR) trials. We aimed investigate according DM across entire spectrum outpatients AS. Methods Between May 2016 and December 2017, mild (peak velocity=2.5–2.9 m/s), moderate (3–3.9 m/s) (≥4 graded by echocardiography were included during outpatient cardiology visits Nord-Pas-de-Calais region France followed-up...
Abstract Aims To investigate the additional prognostic value of myocardial work (MW) parameters following acute infarction (AMI). Methods and results Between 2018 2020, 244 patients admitted in cardiac intensive care unit Lille University Hospital for AMI were included. One-month AMI, comprehensive transthoracic echocardiography (TTE) was performed to assess function. Patients then followed major events (ME): cardiovascular death, heart failure, unplanned coronary revascularization. At...
The chronic management of post-acute aortic dissection (AD) the descending aorta (Type B) is based on optimal control blood pressure (BP), with a target BP < 135/80 mmHg. aim our study was to determine and verify effective an objective measurement method identify predicting factors.We collected data from 26 patients hospitalized in acute phase Type B AD between 2006 2009. Two groups were defined according 24 hour monitoring results at follow-up. Group 1 consisted controlled (<130/80 mmHg), 2...