Sandro Ninni
A5055523197- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Congenital Heart Disease Studies
- Cardiovascular Disease and Adiposity
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- S100 Proteins and Annexins
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiomyopathy and Myosin Studies
- Venous Thromboembolism Diagnosis and Management
- Acute Myeloid Leukemia Research
- Liver Disease Diagnosis and Treatment
- Infective Endocarditis Diagnosis and Management
- Nitric Oxide and Endothelin Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Institut Pasteur de Lille
2016-2025
Inserm
2016-2025
Université de Lille
2016-2025
Centre Hospitalier Universitaire de Lille
2016-2025
Lung Institute
2025
Lille’s Cardiology Hospital
2015-2024
Montreal Heart Institute
2023-2024
Université de Montréal
2023-2024
University of Chicago
2022
Agostino Gemelli University Polyclinic
2022
There has been an increasing focus on integrated, multidisciplinary, and holistic care in the treatment of atrial fibrillation (AF). The 'Atrial Fibrillation Better Care' (ABC) pathway proposed to streamline integrated AF. We evaluated impact outcomes ABC adherent management a contemporary real-life European-wide AF cohort.Patients enrolled ESC-EHRA EURObservational Research Programme General Long-Term Registry with baseline data evaluate criteria available follow-up were considered for this...
Background: Stereotactic body radiotherapy (SBRT) has been reported as a safe and efficient therapy for treating refractory ventricular tachycardia (VT) despite optimal medical treatment catheter ablation. However, data on the use of SBRT in patients with electrical storm (ES) is lacking. The aim this study was to assess clinical outcomes associated context ES. Methods: This retrospective included who underwent ES from March 2020 2021 one tertiary center (CHU Lille). target volume delineated...
Background: Recurrences of atrial fibrillation (AF) after pulmonary vein isolation (PVI) are mainly due to reconnection. However, a growing number patients have AF recurrences despite durable PVI. The optimal ablative strategy for these is unknown. We analyzed the impact current ablation strategies in large multicenter study. Methods: Patients undergoing redo and presenting PVI were included. freedom from arrhythmia vein-based, linear-based, electrogram-based, trigger-based compared....
Heart failure with reduced (HFrEF) or preserved ejection fraction (HFpEF) is characterized by low-grade chronic inflammation. Circulating neutrophils regroup 2 subtypes termed high- and low-density (HDNs LDNs). LDNs represent less than 2% of total neutrophil under physiological conditions, but their counts increase in multiple pathologies, releasing more inflammatory cytokines extracellular traps (NETs). The aims this study were to assess the differential count role HDNs, LDNs, NETs-related...
Background: Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease, and sudden cardiac death represents an important mode in these patients. Data evaluating implantable cardioverter defibrillator (ICD) this patient population remain scarce. Methods: A Nationwide French Registry including all patients with tetralogy ICD was initiated 2010 by Institute Health Medical Research. The primary time to event end point from implantation first appropriate therapy. Secondary...
Studies assessing radiofrequency ablation (RFA) of ventricular tachycardia (VT) in arrhythmogenic right cardiomyopathy (ARVC) report VT recurrences, but have not evaluated the impact RFA on relevant clinical events during follow-up. We aimed to investigate outcomes a multicentric registry.This study included 49 patients with ARVC (46 definite diagnosis, 3 borderline diagnosis according revised Task Force Criteria) who underwent 92 procedures (83 endocardial, 9 combined endo-epicardial)...
Abstract Aims Heart transplantation (HT) can be proposed as a therapeutic strategy for patients with severe refractory electrical storm (ES). Data in the literature are scarce and based on case reports. We aimed at determining characteristics survival of transplanted ES. Methods results Patients registered HT waiting list during following days after ES eventually transplanted, from 2010 to 2021, were retrospectively included 11 French centres. The primary endpoint was in-hospital mortality....
Atrial cardiomyopathy is defined as any complex of structural, architectural, contractile or electrophysiological changes affecting atria, with the potential to produce clinically relevant manifestations. Most our knowledge about mechanistic aspects atrial derived from studies investigating animal models fibrillation and tissue samples obtained individuals who have a history fibrillation. Several non-invasive tools been reported characterize in patients, which may be for predicting risk...
For assessing predictors of early mortality following hospitalization for electrical storm (ES), only limited data are available. The purpose this study was to assess the incidence and in intensive care unit (ICU) ES a large retrospective study.In study, we included all patients who were hospitalized from July 2015 May 2020 our tertiary centre. A total 253 included. median age 66 [56; 73], 64% had ischemic cardiomyopathy. 37% presented hemodynamic instability requiring catecholamine at...
Little is known about patients with right bundle branch block (RBBB)-ventricular tachycardia (VT) and arrhythmogenic cardiomyopathy (ACM). Our aims were: (i) to describe electrocardiogram (ECG) characteristics of sinus rhythm (SR) VT; (ii) correlate SR RBBB-VT ECGs; (iii) compare VT ECGs electro-anatomic mapping (EAM) data.From the European Survey on ACM, 70 spontaneous were included. Putative left ventricular (LV) sites origin (SOOs) estimated a VT-axis-derived methodology confirmed by EAM...
ABSTRACT Introduction Radiofrequency ablation is a cornerstone therapy for patients with ischemic cardiomyopathy (ICM) presenting ventricular tachycardia (VT). In this context, typically performed endocardially as first‐line approach. However, despite acute procedural success, the risk of recurrence remains high, potentially due to presence epicardial substrate. Several observational studies have suggested potential benefits endo‐epicardial approach in decreasing recurrence. EPIC‐VT trial...
Background A number of epidemiological studies have suggested an association between metabolic dysfunction-associated fatty liver disease (MAFLD) and the incidence atrial fibrillation (AF). However, pathogenesis leading to AF in context MAFLD remains unclear. We therefore aimed at assessing impact fibrosis status on left atrium (LA) structure function. Methods Patients with a Fatty Liver Index (FLI) >60 presence comorbidities were classified as MAFLD+. In MAFLD+ patients, severity was...