A5040559085- Antibiotics Pharmacokinetics and Efficacy
- Antifungal resistance and susceptibility
- HIV/AIDS drug development and treatment
- Pharmacological Effects and Toxicity Studies
- Malaria Research and Control
- Epilepsy research and treatment
- HIV Research and Treatment
- Pharmaceutical studies and practices
- Fungal Infections and Studies
- Pneumonia and Respiratory Infections
- Drug Transport and Resistance Mechanisms
- HIV-related health complications and treatments
- Drug-Induced Hepatotoxicity and Protection
- Antibiotic Resistance in Bacteria
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Research and Interventions
- Medication Adherence and Compliance
- Antimicrobial Resistance in Staphylococcus
- Blood Pressure and Hypertension Studies
- Orthopedic Infections and Treatments
- Computational Drug Discovery Methods
- Pharmacogenetics and Drug Metabolism
- Infectious Diseases and Mycology
- Neonatal and fetal brain pathology
- Statistical Methods in Clinical Trials
Inserm
2015-2025
Université Paris Cité
2013-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Sorbonne Paris Cité
2014-2025
Sorbonne Université
2022-2025
Université Sorbonne Paris Nord
2020-2025
Hôpital Jean-Verdier
2022-2024
Université Paris-Saclay
2024
Bicêtre Hospital
2024
Nantes Université
2022
<h3>Importance</h3> Although frequently used in treating intensive care unit (ICU) patients with sepsis, empirical antifungal therapy, initiated for suspected fungal infection, has not been shown to improve outcome. <h3>Objective</h3> To determine whether micafungin reduces invasive infection (IFI)–free survival at day 28. <h3>Design, Setting, and Participants</h3> Multicenter double-blind placebo-controlled study of 260 nonneutropenic, nontransplanted, critically ill ICU-acquired...
Background: The DENERHTN trial (Renal Denervation for Hypertension) confirmed the blood pressure–lowering efficacy of renal denervation added to a standardized stepped-care antihypertensive treatment resistant hypertension at 6 months. We report influence adherence on pressure control. Methods: One hundred six patients with 4 weeks indapamide 1.5 mg/d, ramipril 10 mg/d (or irbesartan 300 mg/d), and amlodipine were randomly assigned plus treatment, or same alone. For spironolactone 25...
Antibiotics have been shown to improve hidradenitis suppurativa (HS) patients but complete remission is rare using these treatments.To assess the efficacy and safety of a combination oral rifampin, moxifloxacin metronidazole in long-lasting refractory HS.We retrospectively studied 28 consecutive HS including 6, 10 12 Hurley stage 1, 2 3 patients, respectively. Complete remission, defined as clearance all inflammatory lesions hypertrophic scars, was main outcome criterion study.Complete...
Hidradenitis suppurativa (HS) is an inflammatory skin disease typically localized in the axillae and inguinal perineal areas. In absence of standardized medical treatment, severe HS patients present chronic suppurative lesions with polymicrobial anaerobic abscesses. Wide surgery cornerstone treatment HS, but surgical indications are limited by extent lesions. Intravenous broad-spectrum antibiotics may help control their efficacy not documented. This study was designed to assess a 6 week...
Patients initiating docetaxel chemotherapy were genotyped for CYP3A4, CYP3A5, MDR1, GSTM1, GSTT1, GSTM3, and GSTP1 to identify variability factors of pharmacokinetics toxicity.Genotyping was performed by direct sequencing (CYP3A4), real-time polymerase chain reaction (CYP3A5), reaction-restriction fragment length polymorphism (MDR1 GST). The clearance area under the curve calculated use a Bayesian approach. Absolute neutrophil count recorded twice weekly.With regard pharmacokinetic analysis,...
Posaconazole is a potent broad-spectrum triazole antifungal. Little known about the prevalence and risk factors for low plasma posaconazole concentrations (PPCs). We retrospectively reviewed all adult patients whose PPCs were measured after at least 5 days of treatment between April 2006 July 2008 Hôpital Necker Enfants Malades. A PPC was defined as concentration lower than 500 ng/ml. Fifty-four included: 36 receiving prophylactic (200 mg three times day) 18 curative (400 twice therapy. The...
ABSTRACT This study was performed to investigate placental transfer of nucleoside analogue reverse transcriptase inhibitors (NRTIs) and their concentrations in amniotic fluid when given human immunodeficiency virus (HIV)-infected pregnant women. A total 100 HIV type 1-infected mothers receiving antiretroviral therapy, including one or more NRTIs, for clinical indications at the time delivery were enrolled. Maternal blood samples obtained during cesarean section, paired cord by venipuncture...
The influence of renal function on tenofovir pharmacokinetics was investigated in 193 human immunodeficiency virus (HIV)-infected patients by the use a population approach performed with nonlinear mixed effects modeling program NONMEM. Tenofovir well described two-compartment open model which absorption and distribution rate constants are equal. Typical estimates apparent central volume (V(c)/F), peripheral (V(p)/F), intercompartmental clearance (Q/F), plasma (CL/F) were 297 +/- 28.5...
This study was performed to describe clindamycin, administered either orally or intravenously, concentration-time courses patients with osteomyelitis, the effects of different covariates on clindamycin pharmacokinetics and simulate an optimized administration scheme.Clindamycin concentrations were measured in 50 patients. A total 122 plasma available (58 from oral 64 i.v. infusion). population pharmacokinetic model developed MONOLIX 4 software.A one compartment adequately described data....
To identify the factors associated with interindividual pharmacokinetic (PK) variability of micafungin and to evaluate probability reaching previously determined PK/pharmacodynamic efficacy thresholds (AUC/MIC >5000 for non-parapsilosis Candida sp. ≥285 parapsilosis) recommended 100 mg daily dose in ICU patients sepsis mechanical ventilation. One hundred were included 436 concentrations available PK analysis performed NONMEM software. PTA was by Monte Carlo simulations. Micafungin obeyed a...
Nonadherence to antihypertensive therapy is an important cause of poor blood pressure control. However, date, few effective and accurate tools exist routinely evaluate drug nonadherence.In this observational study, performed under conditions routine clinical practice, we included 174 patients (aged 67 ± 11 years) with treated essential hypertension who attended the outpatient clinic a university hospital. Adherence treatment was measured by using ultraperformance liquid chromatography-tandem...
Summary. Although hepatitis C virus (HCV) infection prevalence is high among drug users, they do not commonly receive regular care in academic centres. The aim of this prospective study was to assess the influence FibroScan use on HCV screening and management street‐based outreach. From January 2006 2007, all consecutive users were offered noninvasive evaluation liver fibrosis with FibroScan. After FibroScan, parameters recorded a structured, face‐to‐face questionnaire by outreach workers....
Summary Purpose: To develop a population pharmacokinetic model to evaluate the demographic and physiologic determinants of levetiracetam (LEV) pharmacokinetics (PK) suggest recommended doses LEV in children. Methods: PK were investigated prospective open trial as adjunctive therapy using approach performed with NONMEM (Nonlinear Mixed Effects Model) on 170 concentration–time records covariate information from 44 children between 4 16 years age. Possible associations parameters age, gender,...
ABSTRACT In order to study the pharmacokinetic properties of amodiaquine and desethylamodiaquine during pregnancy, 24 pregnant women in second third trimesters pregnancy with Plasmodium vivax malaria were treated (10 mg/kg body weight/day) for 3 days. The same studied again at months postpartum. Plasma was analyzed by use a liquid chromatography-tandem mass spectrometry method. Individual concentration-time data evaluated using noncompartmental analysis. There no clinically relevant...