A5030497903- Nosocomial Infections in ICU
- Antifungal resistance and susceptibility
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Fungal Infections and Studies
- Antibiotic Resistance in Bacteria
- Pneumocystis jirovecii pneumonia detection and treatment
- Hemodynamic Monitoring and Therapy
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Family and Patient Care in Intensive Care Units
- Bacterial Identification and Susceptibility Testing
- Neonatal and Maternal Infections
- Vasculitis and related conditions
- Immune Response and Inflammation
- Viral Infections and Vectors
- Palliative Care and End-of-Life Issues
- Atrial Fibrillation Management and Outcomes
- Emergency and Acute Care Studies
- Mycobacterium research and diagnosis
Université de Bourgogne
2014-2024
Inserm
2008-2024
Centre de recherche Translationnelle en Médecine moléculaire
2016-2023
Hospices Civils de Lyon
2023
Hôpital Lyon Sud
2023
Maison des Sciences de l’Homme de Dijon
2004-2022
CHU Dijon Bourgogne
2012-2021
Fondation de Coopération Scientifique
2020-2021
Université Bourgogne Franche-Comté
2017-2021
Agroécologie
2012-2016
Objective: To assess the usefulness of "Candida score" (CS) for discriminating between Candida species colonization and invasive candidiasis (IC) in non-neutropenic critically ill patients. A rate IC <5% patients with CS <3 was primary end point. Design: Prospective, cohort, observational study. Setting: Thirty-six medical-surgical intensive care units Spain, Argentina, France. Patients: total 1,107 adult unit admitted at least 7 days April 2006 June 2007. Measurements Main Results: Clinical...
Although the outcome of sepsis benefits from prompt administration appropriate antibiotics on correct diagnosis, assessment infection in critically ill patients is often a challenge for clinicians. In this setting, simple biomarkers, especially when used combination, could prove useful.To determine usefulness combination biomarkers to diagnose sepsis.Three hundred consecutive were enrolled construct biologic score that was next validated an independent prospective cohort 79 another...
Objective: To determine whether the use of a nurse-implemented sedation protocol could reduce incidence ventilator-associated pneumonia in critically ill patients. Design: Two-phase (before–after), prospective, controlled study. Setting: University-affiliated, 11-bed medical intensive care unit. Patients: Patients requiring mechanical ventilation for ≥48 hrs and sedative infusion with midazolam or propofol alone. Interventions: During control phase, sedatives were adjusted according to...
In the ICU, bacteremia is a life-threatening infection whose prognosis highly dependent on early recognition and treatment with appropriate antibiotics. Procalcitonin levels have been shown to distinguish between noninfectious inflammatory states accurately quickly in critically ill patients. However, we still do not know what extent magnitude of PCT elevation at onset varies according Gram stain result.Review medical records every patient treated May, 2004 December, 2006 who had caused by...
<h3>Importance</h3> Although frequently used in treating intensive care unit (ICU) patients with sepsis, empirical antifungal therapy, initiated for suspected fungal infection, has not been shown to improve outcome. <h3>Objective</h3> To determine whether micafungin reduces invasive infection (IFI)–free survival at day 28. <h3>Design, Setting, and Participants</h3> Multicenter double-blind placebo-controlled study of 260 nonneutropenic, nontransplanted, critically ill ICU-acquired...
Management of the early stage sepsis is a critical issue. As part it, infection control including appropriate antibiotic therapy administration should be prompt. However, microbiological findings, if any, are generally obtained late during course disease. The potential interest procalcitonin (PCT) as way to assess clinical efficacy empirical was addressed in present study.An observational cohort study 180 patients with documented conducted our 15-bed medical intensive care unit (ICU)....
Background: Intra-abdominal infections are frequent and life-threatening complications after colorectal surgery. An early detection could diminish their clinical impact permit safe discharge. Objective: This study aimed to find the most accurate marker for of postoperative intra-abdominal infection appropriate moment measure it. Methods: A prospective, observational was conducted in 3 centers. Consecutive patients undergoing elective surgery with anastomosis were included. C-reactive protein...
Objective. The aim of this study was to describe the presentation and outcomes patients with granulomatosis polyangiitis (GPA) presenting CNS involvement.
Abstract In the context of worldwide increasing antimicrobial resistance, good prescribing in more needed than ever; unfortunately, information available to clinicians often are insufficient rely on. Biomarkers might provide help for decision-making and improve antibiotic management. The purpose this expert panel review was examine currently literature on potential role biomarkers prescribing, by answering three questions: 1) Which purpose?; 2) What is their initiation therapy?; 3) decision...
The use of novel sepsis biomarkers has increased in recent years. However, their prognostic value with respect to illness severity not been explored. In this work, we examined the ability mid-regional proadrenomedullin (MR-proADM) predicting mortality patients different degrees organ failure, compared that procalcitonin, C-reactive protein and lactate. This was a two-centre prospective observational cohort, enrolling severe or septic shock admitted ICU. Plasma were measured during first 12 h...
Abstract Background COVID-19-related ARDS has unique features when compared with from other origins, suggesting a distinctive inflammatory pathogenesis. Data regarding the host response within lung are sparse. The objective is to compare alveolar and systemic inflammation patterns, mitochondrial alarmin release, outcomes according etiology (i.e., COVID-19 vs. non-COVID-19). Methods Bronchoalveolar lavage fluid plasma were obtained 7 control, non-COVID-19 ARDS, 14 patients. Clinical data,...
Abstract Background Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting unique immunopathogenesis. Methods Thirty-six immunocompetent non-COVID-19 27 patients with severe pneumonia were prospectively enrolled single center, requiring intensive care. Clinical biological (including T cell phenotype function plasma concentrations of 30...
The French National Reference Center for Invasive Mycoses and Antifungals leads an active sustained nationwide surveillance program on probable proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 2018, a total of 10,886 IFDs were recorded. incidence increased slightly over time (2.16 2.36/10,000 hospitalization days, P = 0.0562) relation with increase fungemia (1.03 1.19/10,000, 0.0023), while that other remained stable. proportion ≥65-year-old...
ABSTRACT We report a case of cryptococcosis in which serum enzyme-linked immunosorbent assay (ELISA) for Aspergillus galactomannan was positive, with no evidence aspergillosis. Soluble antigens from 19 Cryptococcus neoformans strains and purified carbohydrates C. capsule were thus assayed the ELISA. Antigens all strains, galactoxylomannan, gave positive reaction, suggesting that galactoxylomannan contains an epitope(s) is cross-reactive galactomannan.
Abstract Biomarker-guided initiation of antibiotic therapy has been studied in four conditions: acute pancreatitis, lower respiratory tract infection (LRTI), meningitis, and sepsis the ICU. In pancreatitis with suspected infected necrosis, initiating antibiotics best relies on fine-needle aspiration demonstration material. We suggest that PCT be measured to help predict infection; however, available data are insufficient decide based levels. adult patients community-acquired LRTI, we...
Purpose We investigated incidence, risk factors for new-onset atrial fibrillation (NAF), and prognostic impact during septic shock in medical Intensive Care Unit (ICU) patients. Methods Prospective, observational study a university hospital. Consecutive patients from 03/2011 to 05/2013 with were eligible. Exclusion criteria age <18 years, history of AF, transfer prior shock. Included equipped long-duration (7 days) Holter ECG monitoring. NAF was defined as an AF episode lasting >30 seconds....
To identify the factors associated with interindividual pharmacokinetic (PK) variability of micafungin and to evaluate probability reaching previously determined PK/pharmacodynamic efficacy thresholds (AUC/MIC >5000 for non-parapsilosis Candida sp. ≥285 parapsilosis) recommended 100 mg daily dose in ICU patients sepsis mechanical ventilation. One hundred were included 436 concentrations available PK analysis performed NONMEM software. PTA was by Monte Carlo simulations. Micafungin obeyed a...
For some pneumococci the fluoroquinolone MICs are low but mutant prevention concentrations (MPCs) high; this difference defines in vitro selection window (MSW). We investigated vivo bacterial reduction and occurrence of resistant mutants with moxifloxacin (MFX; 400 mg once daily) or levofloxacin (LVX; 500 twice treatments similar to those humans experimental pneumonia due (expPP) exhibiting various MPCs. The MIC/MPC for MFX LVX genotypes were as follows: strain 16089, 0.125/0.125 0.5/0.5...