A5012917056- Mosquito-borne diseases and control
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Toxoplasma gondii Research Studies
- Malaria Research and Control
- Research on Leishmaniasis Studies
- Viral Infections and Vectors
- Parasitic Infections and Diagnostics
- Trypanosoma species research and implications
- Nail Diseases and Treatments
- Rabies epidemiology and control
- Zoonotic diseases and public health
- HIV/AIDS oral health manifestations
- Pneumocystis jirovecii pneumonia detection and treatment
- Vector-borne infectious diseases
- Leptospirosis research and findings
- Herpesvirus Infections and Treatments
- Parasites and Host Interactions
- Travel-related health issues
- Cytomegalovirus and herpesvirus research
- Plant Pathogens and Fungal Diseases
- Streptococcal Infections and Treatments
- Migration, Identity, and Health
- SARS-CoV-2 and COVID-19 Research
- Syphilis Diagnosis and Treatment
Centre Hospitalier Andrée Rosemon
2016-2025
University of French Guiana
2016-2025
Institut Pasteur de Lille
2021-2024
Inserm
2014-2024
Centre National de la Recherche Scientifique
2021-2024
Center for Infection and Immunity of Lille
2021-2024
Centre Hospitalier Universitaire de Lille
2024
Centre Hospitalier Universitaire Pointe-à-Pitre
2024
Centre Hospitalier Universitaire de Caen Normandie
2014-2023
Université de Nîmes
2023
Well-documented outbreaks of human toxoplasmosis infection are infrequently reported. Here, we describe a community outbreak multivisceral that occurred in Patam, Surinamese village near the French Guianan border.From end December 2003 through middle January 2004, 5 adult patients including 2 pregnant women, were initially hospitalized for toxoplasmosis. A French-Surinamese epidemiological investigation was conducted village; inquiries and clinical examinations performed, blood environmental...
Antimalarial drug resistance has historically arisen through convergent de novo mutations in Plasmodium falciparum parasite populations Southeast Asia and South America. For the past decade Asia, artemisinins, core component of first-line antimalarial therapies, have experienced delayed clearance associated with several pfk13 mutations, primarily C580Y. We report that mutant emerged independently Guyana, genome analysis indicating an evolutionary origin distinct from Asia. Pfk13 C580Y...
ABSTRACT The most common presentation of symptomatic postnatally acquired toxoplasmosis in immunocompetent patients is painless cervical adenopathy. Acute visceral manifestations are associated rare cases. We report 16 cases severe primary diagnosed French Guiana during a 6.5-year period. All the subjects were adults hospitalized with clinical presentations consisting marked, nonspecific infectious syndrome accompanied by an altered general status at least one localization, mainly pulmonary...
From 1998 through 2006, 44 cases of severe primary toxoplasmosis were observed in French Guiana immunocompetent adults. Toxoplasma gondii isolates exhibited an atypical multilocus genotype. Severe disease humans may result from poor host adaptation to neotropical zoonotic strains T. circulating a forest-based cycle.
Malaria is endemic in French Guiana, an overseas territory of France on the Guiana Shield. Since 2005, notified malaria cases are decreasing. However, new data show that affects many Brazilian gold miners working illegally majority whom not counted official data. In addition, one major concern usual practice improper self-treatment this mining population, raising fear development anti-malarial resistance. This prospective study, conducted 2015, aimed to estimate prevalence Plasmodium spp....
In French Guiana, a overseas territory in South America, 6 to 10 thousands undocumented persons work illegally gold mining sites the Amazonian forest. Precarious life conditions lead poor health but few data exist on status of illegal miners Guiana. The objective this article was describe sociodemographic and vulnerable population. A prospective cross-sectional survey conducted 2015 mine supply at border between Guiana Suriname. Health assessed through medical examination, past history,...
The French National Reference Center for Invasive Mycoses and Antifungals leads an active sustained nationwide surveillance program on probable proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 2018, a total of 10,886 IFDs were recorded. incidence increased slightly over time (2.16 2.36/10,000 hospitalization days, P = 0.0562) relation with increase fungemia (1.03 1.19/10,000, 0.0023), while that other remained stable. proportion ≥65-year-old...
Objective: Histoplasma capsulatum var. infection is a major AIDS-defining illness in French Guiana. Although it affects South and Central American countries, the number of published cases low. We present largest series AIDS-related histoplasmosis. The aim this work to describe clinical features help optimize investigations settings where antigen detection methods are not available. Design: Two hundred histoplasmosis, diagnosed hospitals Guiana, were included retrospectively between 1982...
Background Histoplasmosis is an endemic fungal infection in French Guiana. It the most common AIDS-defining illness and leading cause of AIDS-related deaths. Diagnosis difficult, but past 2 decades, it has improved this overseas territory which offers interesting model Amazonian pathogen ecology. The objectives present study were to describe temporal trends incidence mortality indicators for HIV-associated histoplasmosis Methods A retrospective was conducted early rates observed persons...
An outbreak of severe acute respiratory syndrome coronavirus 2 caused by the Gamma variant concern infected 24/44 (55%) employees a gold mine in French Guiana (87% symptomatic, no forms). The attack rate was 60% (15/25) among fully vaccinated miners and 75% (3/4) unvaccinated without history infection.
Illegal gold miners are currently key hosts for malaria in French Guiana (FG), with a risk of emergence resistance linked to improper use artemisinin-based combination therapy (ACT). The remoteness the mines and regulatory issues hinder their access health care. A quasi-experimental researched project (Malakit) implemented FG borders Brazil Suriname aimed at determining effectiveness distributed kits self-diagnosis self-treatment illegal miners, after training, strategic border staging...
French Guiana (FG) was the first country in South America to declare chikungunya virus infection (CHIKV). The outbreak affected about 16,000 persons between February 2014 and October 2015, with several atypical cases, but only two fatal cases. We aimed describe clinical presentation of patients hospitalized for CHIKV infection, estimate identify risk factors unusual severe forms adult patients.A monocentric retrospective study conducted Cayenne hospital, main city hospital FG, from March 1st...
Disseminated histoplasmosis is the first AIDS-defining infection in French Guiana. A retrospective cohort study studied predictive factors of disseminated HIV-infected patients between 1996 and 2008. Cox proportional hazards models were used. The variables age, sex, last CD4/CD8 count, CD4 nadir, herpes or pneumocystosis, cotrimoxazole fluconazole use, antiretroviral treatment notion recent initiation HAART. total 1404 followed for 6833 person-years. independently associated with increased...
Zika virus (ZIKV) infection has been associated with complications during pregnancy. Although the presence of symptoms might be a risk factor for complication, proportion ZIKV-infected pregnant women remains unknown. Following emergence ZIKV in French Guiana, all pregnancies territory were monitored by RT-PCR and/or detection antibodies. Follow-up data collected pregnancy monitoring interviews analysed from 1 February to June 2016. We enrolled 3,050 aged 14-48 years and 573 (19%) had...
Background Toxoplasmic encephalitis in patients with AIDS is a life-threatening disease mostly due to reactivation of Toxoplasma gondii cysts the brain. The main objective this study was evaluate performance real-time PCR assay peripheral blood samples for diagnosis toxoplasmic French West Indies and Guiana. Methodology/Principal Findings Adult HIV suspicion start specific antitoxoplasmic therapy were included during 40 months. targeting 529 bp repeat region T. performed two different...
Oropouche fever is a zoonotic dengue-like syndrome caused by virus. In August-September 2020, developed in 41 patients remote rainforest village French Guiana. By PCR or microneutralization, 23 (82.1%) of 28 tested were positive for virus, documenting its emergence
Human brucellosis is a zoonoses caused by bacteria of the genus Brucella. Infection results in subacute or chronic debilitating disease with nonspecific clinical manifestations and often associated consuming unpasteurized dairy products. We report 2 cases male patients who were hospitalized distinct towns French Guiana, an overseas territory France located on northeastern shore South America. Both men citizens Brazil working as clandestine goldminers deep Amazonian rainforest....
Acute Q fever is an emergent and severe disease in French Guiana. We obtained 5 Coxiella burnetii isolates from samples of patients Cayenne found epidemic clone circulating Cayenne. This has caused pneumonia endocarditis seems to be more virulent than previously described strains.