A5035538020- Mosquito-borne diseases and control
- Malaria Research and Control
- Iron Metabolism and Disorders
- Child Nutrition and Water Access
- Indigenous Health and Education
- Health, Nursing, Elderly Care
- Global Maternal and Child Health
- Zoonotic diseases and public health
- Public Health in Brazil
- Maternal and Neonatal Healthcare
- Fish biology, ecology, and behavior
- Healthcare Regulation
- Parasites and Host Interactions
- Travel-related health issues
- Leprosy Research and Treatment
- Research on Leishmaniasis Studies
- Vibrio bacteria research studies
- Venomous Animal Envenomation and Studies
- Yersinia bacterium, plague, ectoparasites research
- COVID-19 epidemiological studies
- Education, Politics, and Culture Studies
- Pharmacological Effects and Toxicity Studies
- Leptospirosis research and findings
- Social and Economic Solidarity
- Banana Cultivation and Research
Ministério da Saúde
2015-2024
Secretaria da Saúde
2022
Universidade Federal de Roraima
2022
Ministério da Saúde
2022
Ministry of Health of the Russian Federation
2021
World Vision
2021
Australian National University
2021
Universidade de São Paulo
2014-2015
Universidade Brasil
2014-2015
Pan American Health Organization (Brasil)
2012
Abstract Purpose of Review Following Paraguay and Argentina, several countries from the Amazon region aim to eliminate malaria. To achieve this, all key affected vulnerable populations by malaria, including people working on gold mining sites, must be considered. What is situation malaria in these particular settings what are challenges? This literature review aims compile knowledge answer questions. Recent Findings The contexts which miners operate very heterogeneous: size localization...
Abstract Background Endemic malaria is present in all 15 municipalities of Roraima state, Brazilian Amazonia. Knowledge epidemiological data specific populations can guide health policies to formulate effective strategies for integrated control health-disease care. This study aims ascertain when, where and who fell ill with state from 2010 2020. Methods descriptive was based on statistical secondary surveillance through the analysis relationships underlying numbers cases, hospitalizations...
In most of the Americas, recommended treatment to prevent relapse Plasmodium vivax malaria is primaquine at a total dose 3.5 mg per kilogram body weight, despite evidence only moderate efficacy.In this trial conducted in Brazil, we evaluated three regimens P. children least 5 years age and adults with microscopy-confirmed monoinfection. All patients received directly observed chloroquine for 3 days (total dose, 25 kilogram). Group 1 (0.5 day) over 7 unobserved administration; group 2 same...
In Brazil, 99% of malaria cases occur in the Amazon region, mainly caused by Plasmodium vivax (~83%) and falciparum ( Pf ) species. Aligned with Sustainable Development Goals, Brazil aims to eliminate autochthonous 2035. This study analyse epidemiological patterns discuss if is on track meet control targets. A time-series was conducted analysing new infections notifications Brazilian region from 2011 until June 2023. Descriptive analyses were conducted, along joinpoint regression forecast...
The Guiana Shield, a small region of South America, is currently one the main hotspots malaria transmission on continent. This Amazonian area characterised by remarkable socioeconomic, cultural, health, and political heterogeneity high degree regional cross-border population mobility, which has contributed to increase in past few years. In this context, cooperation control represents both challenge an indispensable initiative. Viewpoint advocates for creation cooperative mechanism...
Illegal gold miners in French Guiana, a overseas territory ('département') located Amazonia, often carry malaria parasites (up to 46.8%). While the Guiana Shield Region aims at elimination, high prevalence of Plasmodium this hard-to-reach population conjunction with frequent incorrect use artemisinin-based anti-malarials could favour emergence resistant parasites. Due geographical and regulatory issues usual control strategies cannot be implemented particular context. Therefore, new...
Brazil is the largest country of Latin America, with a considerable portion its territoritory within malaria-endemic Amazon region in North. Furthermore, territory located north. As result, has reported half total malaria cases Americas last four decades. Recent progress control been accompanied by an increasing proportion Plasmodium vivax, underscoring need for better understanding management and this species associated challenges. Among these challenges, contribution vivax relapses,...
Abstract Background As malaria endemic countries strive towards elimination, intensified spatial heterogeneities of local transmission could undermine the effectiveness traditional intervention policy. Methods The dynamic nature large-scale and long-term heterogeneity across Brazilian Amazon basin were explored by (1) exploratory analysis Brazil’s rich clinical reporting database from 2004 to 2018, (2) adapting Gini coefficient study distribution cases in region. Results declined, increased...
Illegal gold miners are currently key hosts for malaria in French Guiana (FG), with a risk of emergence resistance linked to improper use artemisinin-based combination therapy (ACT). The remoteness the mines and regulatory issues hinder their access health care. A quasi-experimental researched project (Malakit) implemented FG borders Brazil Suriname aimed at determining effectiveness distributed kits self-diagnosis self-treatment illegal miners, after training, strategic border staging...
<title>Abstract</title> Background Malaria is an acute infectious disease with its occurrence in Brazil concentrated the Amazon region. But it extra-amazon region where lethality higher. Therefore, this study aimed to analyze factors associated malaria hospitalizations extra-Amazon of Brazil. Methods A case-control design was used, utilizing data from Brazilian Notifiable Diseases Information System (Sinan) and hospitalization records Unified Health (SIH/SUS) 2011 2019. Cases comprised...
Control of vivax malaria in endemic areas requires management recurrence. The Brazilian National Malaria Surveillance System (SIVEP-Malária) records every case Brazil, but is not designed to differentiate between primary and recurrent infections. aim this study was explore whether the information provided by SIVEP-Malária could be used identify Plasmodium recurrences, its risk factors evaluate effectiveness short course primaquine (7-9 days: total dose 3-4.2 mg/kg) preventing relapses.In...
Roraima state is the northernmost in Brazil and primary border-crossing point between Venezuela. The uncontrolled surge of malaria Venezuela, coupled with mass migration Venezuelans to neighbouring countries upward trend informal mining state, pose a serious threat broader region, especially migrant, indigenous populations, jeopardizing elimination efforts. This study describes changes epidemiological profile related time, place populations at risk from 2016 2020.De-identified surveillance...
Abstract Globally, cross-border importation of malaria has become a challenge to elimination. The border areas between Brazil and Venezuela have experienced high numbers imported cases due increased population movement migration out Venezuela. This study aimed identify risk factors for delineate hotspots in Roraima, Bolivar, 2016 2018. Data on surveillance from 2018 were obtained national systems: the Brazilian Malaria Epidemiology Surveillance Information System (SIVEP-Malaria), Venezuelan...
An interventional study named Malakit was implemented between April 2018 and March 2020 to address malaria in gold mining areas French Guiana, collaboration with Suriname Brazil. This innovative intervention relied on the distribution of kits for self-diagnosis self-treatment miners after training by health mediators, referred project as facilitators.
Abstract Background Studies in South-East Asia have suggested that early diagnosis and treatment with artesunate (AS) mefloquine (MQ) combination therapy may reduce the transmission of Plasmodium falciparum malaria progression MQ resistance. Methods The effectiveness a fixed-dose AS (ASMQ) reducing was tested isolated communities Juruá valley Amazon region. Priority municipalities within Brazilian Legal area were selected according to pre-specified criteria. Routine national control...
Abstract Background There is general international agreement that the importance of vivax malaria has been neglected, and there a need for new treatment approaches in an effort to progress towards control elimination Latin America. This open label randomized clinical trial evaluated efficacy safety three regimens using either one two fixed dose artemisinin-based combinations or chloroquine combination with short course primaquine (7–9 days: total 3–4.2 mg/kg) Brazil. The primary objective...
We evaluated the efficacy of chloroquine and primaquine on uncomplicated Plasmodium vivax malaria in Cruzeiro do Sul, Brazil, 2014. Patients ≥ 5 years age with either fever or history fever, laboratory-confirmed P. monoinfection received (total dose = 25 mg/kg) 3.5 mg/kg), were followed up for 168 days (24 weeks). used microsatellite genotyping to differentiate recurrent infections caused by heterologous parasites from those homologous ones. No new episode occurred Day 28 among 119 enrolled...
The first potential focus for artemisinin resistance in South America was recently confirmed with the presence of C580Y mutation Plasmodium falciparum kelch 13 gene (pfk13) Guyana.This study aimed to strengthen pfk13 monitoring Amazon basin countries, compile available data and evaluate risk spreading mutations.Sanger sequencing done on 862 samples collected between 1998 2019, a global map genotypes this region constructed. Then, mutations based P. case importation 2015 2018 within countries...
Abstract In 2020, 77% of malaria cases in the Americas were concentrated Venezuela, Brazil, and Colombia. These countries are characterized by a heterogeneous landscape hotspots. Furthermore, political unrest Venezuela has led to significant cross-border population movement. Hence, aim this study was describe spatial patterns identify climatic drivers transmission along Venezuela-Brazil-Guyana border, focusing on Bolivar state, Roraima Brazil. Malaria case data, stratified species from 2016...
Malaria remains a major public health problem, with half the world population at risk of contracting malaria. The effects Plasmodium vivax on prosperity and longevity have been highlighted in several recent clinical case reports. first line treatment drugs has seen no radical innovation for more than 60 years. This study introduces subtle incremental to treatment: chloroquine primaquine co-blister. co-blister includes new formulation incorporating coated tablets mask drug's bitter taste...
Conventional molecular methods, such as nested polymerase chain reaction (PCR), are very sensitive for detection of malaria parasites, but require advanced laboratory equipment and trained personnel. Real-time loop-mediated isothermal amplification (RealAmp), a amplification-based tool (LAMP), facilitates rapid target at single temperature setting, reducing the need sophisticated equipment. We evaluated performance field-adapted RealAmp assay diagnosis in Cruzeiro do Sul, Acre State, Brazil,...
Brazilian garimpeiros are a highly hard-to-reach and mobile population, with little access to basic hygiene health services, have been crossing the border work irregularly in gold mines French Guiana since 90s. This study aimed characterize this population identify their main problems. A cross-sectional was carried out municipality of Oiapoque-AP, two surveys: before (2018) after (2019) implementation Malakit. Individuals were recruited from resting places submitted questionnaire demographic...
We evaluated the therapeutic efficacy of artemether–lumefantrine (AL) fixed-dose combination to treat uncomplicated Plasmodium falciparum malaria in Cruzeiro do Sul, Acre State, Amazon region Brazil. Between December 2015 and May 2016, we enrolled 79 patients, 5–79 years old with fever or history previous 48 hours P. monoinfection confirmed by microscopy. Attempts were made provide direct observation phone reminders for all six doses AL, patients followed-up 28 days. AL was well tolerated,...