A5027160839- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- Global Maternal and Child Health
- Virology and Viral Diseases
- Fire effects on ecosystems
- Zoonotic diseases and public health
- Vector-Borne Animal Diseases
- COVID-19 Impact on Reproduction
- Influenza Virus Research Studies
- Dengue and Mosquito Control Research
- Rabies epidemiology and control
- Venomous Animal Envenomation and Studies
- Respiratory viral infections research
- Muscle and Compartmental Disorders
- Yersinia bacterium, plague, ectoparasites research
- Immune responses and vaccinations
- Nosocomial Infections in ICU
- Leptospirosis research and findings
- Bacteriophages and microbial interactions
- Health, Medicine and Society
- Evolution and Genetic Dynamics
- SARS-CoV-2 and COVID-19 Research
Institut Pasteur de la Guyane
2012-2024
University of French Guiana
2014-2024
Centre Hospitalier Andrée Rosemon
2017-2023
Institut Pasteur
2009-2022
Hôpital de l'enfance
2019
Centre National de la Recherche Scientifique
2019
Inserm
2014
Service de Santé des Armées
2008
Centers for Disease Control and Prevention
2006
Laboratoire National de Référence
2005
On 6 December 2013, two laboratory-confirmed cases of chikungunya without a travel history were reported on the French part Caribbean island Saint Martin, indicating start first documented outbreak in Americas. Since this report, virus spread to several islands and Guiana, between 2013 27 March 2014 more than 17,000 suspected confirmed have been reported. Further establishment disease Americas is likely, given high number people travelling affected non-affected areas widespread occurrence...
We compared the performance of two new commercial tests for detection dengue NS1 protein during clinical phase virus (DENV) infection-an immunochromatographic test allowing rapid antigen, Dengue Ag STRIP (Bio-Rad Laboratories - Marnes La Coquette, France), and a two-step sandwich-format microplate enzyme-linked immunosorbent assay (ELISA), pan-E Early ELISA (Panbio Brisbane, Australia)-with one-step ELISA, Platelia (Bio-Rad).We tested 272 serum samples from patients with disease. Of these,...
To estimate the rates of maternal-fetal transmission Zika virus, adverse fetal/neonatal outcomes, and subsequent asymptomatic/symptomatic congenital virus infections up to first week life.Cohort study with prospective data collection review outcomes.Referral centre for prenatal diagnosis French Guiana Western Hospital.Pregnant women at any stage pregnancy a laboratory confirmed symptomatic or asymptomatic infection during epidemic period in western Guiana. The cohort enrolled 300...
Background Chikungunya virus (CHIKV), an alphavirus and member of the Togaviridae family, is capable causing severe febrile disease in humans. In December 2013 Asian Lineage CHIKV spread from Old World to Americas, spreading rapidly throughout New World. Given this new emergence naïve populations we studied viral genetic diversity present infected individuals understand how may have evolved during continuing outbreak. Methodology/Principle Findings We used deep-sequencing technologies...
In South America, dengue is the arbovirus-transmitted disease with highest incidence. Unlike other arboviruses, wild mammals have no confirmed role in cycle of neotropics, although serological studies suggested a possible secondary amplification involving than nonhuman primates. French Guiana, where all four serotypes (DENV-1, DENV-2, DENV-3, DENV-4) are present, endemic outbreak events. To determine whether can be infected by DENV, rodents, marsupials, and bats were captured over several...
The incidence of dengue worldwide is increasing rapidly. A better understanding transmission may help improve interventions against this major public health problem. virus mostly transmitted by vectors. There are, however, other modes transmission, notably mother-to-child or vertical transmission. We studied a prospective cohort 54 women who had while pregnant during the 2012–2013 epidemic in French Guiana to estimate rate and assess clinical biological presentation neonatal dengue. was...
Global human health is increasingly challenged by emerging viral threats, especially those observed over the last 20 years with coronavirus-related diseases, such as Severe Acute Respiratory Syndrome (SARS) and Middle East (MERS). Recently, in late December 2019, a novel Betacoronavirus, SARS-CoV-2, originating from Chinese city of Wuhan, emerged was then identified causative agent new severe form pneumonia, COVID-19. Real-time genome sequencing outbreaks key issue to confirm identification...
Zika virus (ZIKV) infection has been associated with complications during pregnancy. Although the presence of symptoms might be a risk factor for complication, proportion ZIKV-infected pregnant women remains unknown. Following emergence ZIKV in French Guiana, all pregnancies territory were monitored by RT-PCR and/or detection antibodies. Follow-up data collected pregnancy monitoring interviews analysed from 1 February to June 2016. We enrolled 3,050 aged 14-48 years and 573 (19%) had...
ABSTRACT For clinical and epidemiological purposes, it is necessary to be able classify serological responses during dengue virus infection. Thus, important develop a test that can distinguish between primary secondary responses. The hemagglutination inhibition (HI) test, which currently recommended by the World Health Organization, complicated perform. We developed an enzyme-linked immunosorbent assay based on changes in avidity of immunoglobulin G infectious episode. This discriminate...
Dengue-malaria co-infection reports are scarce. Of 1,723 consecutive febrile patients in Cayenne Hospital, 238 had dengue (174 early fever cases) and 393 malaria (371 acute malaria); 17 both. Diagnosis of 1 these 2 infections should not rule out testing for the other infection.
At the end of 2013, chikungunya virus (CHIKV) emerged in Saint Martin Island, Caribbean. The Asian lineage was identified. Seven months after this introduction, seroprevalence 16.9% population and 39.0% infections remained asymptomatic. This moderate attack rate apparent limited size outbreak could be explained by control measures involved to lower exposure inhabitants. Other drivers such as climatic factors genetic should explored. substantial asymptomatic recorded points a potential source...
Dengue fever is an increasing problem worldwide, but consequences during pregnancy remain unclear. Much of the available literature suffers from methodological biases that compromise validity clinical recommendations. We conducted a matched cohort study epidemic in French Guiana to compare events and outcomes between two paired groups pregnant women: women having presented with symptomatic dengue (n = 73) had neither nor 219). Women each arm were by place follow up, gestation weeks at...
Abstract Background Since the identification of Zika virus (ZIKV) in Brazil May 2015, has spread throughout Americas. However, ZIKV burden general population affected countries remains unknown. Methods We conducted a survey different communities French Guiana through individual interviews and serologic during June–October 2017. All serum samples were tested for anti-ZIKV immunoglobulin G antibodies using recombinant antigen-based SGERPAxMap microsphere immunoassay, some them further...
Reliable serologic tests are needed for diagnosis and surveillance of Zika virus infection. We evaluated the Euroimmun Dia.Pro detection IgM IgG by using a panel 199 samples from region endemic flaviviruses. Kinetics antibodies were monitored 300 sequential specimens sampled over period 10 months after observed suboptimal performance; sensitivity was low, especially in assay (49%), whereas could be detected with Dia.pro assay. The specificity assays also that (62%); findings strongly...
Originating from African forests, Zika virus (ZIKV) has now emerged worldwide in urbanized areas, mainly transmitted by Aedes aegypti mosquitoes. Although albopictus can transmit ZIKV experimentally and was suspected to be a vector Central Africa, the potential of this species sustain transmission yet uncovered until end 2019, when several autochthonous transmissions vectored Ae . occurred France. Aside these few locally acquired infections, most territories colonized have been spared so...
Background Snakebite (SB) envenoming is an acute emergency requiring early care delivery. We aimed to search for the time reach healthcare facilities in various regions of French Guiana (FG) and assess impact antivenom (AV) on correction coagulation parameters these patients. Methodology This a prospective observational study conducted Cayenne General Hospital between January 1st, 2016, July 31st, 2022. included all patients hospitalized SB less than 48h after bite, receiving (AV). assessed...
We evaluated the use of capillary blood samples stored on filter papers for diagnosis dengue virus infection. Venous and were collected from 130 patients suspected having fever. compared performances standard reference methods using absorbed onto versus venous samples. The resulting sensitivity, specificity, positive predictive value tests performed paper to those 81.6% (62/76; 95% confidence interval [CI], 74.9% 88.3%), 90.7% (49/54; CI, 85.7% 95.7%), 92.5% (62/67; 86.2% 98.8%),...
Following of the emergence Zika virus in Brazil 2015, an epidemiological surveillance system was quickly implemented French overseas Territories America (FTA) according to previous experience with dengue and chikungunya has detected first cases Zika. General practitioners medical microbiologists were invited report all clinically suspected Zika, laboratory investigations systematically conducted (RT-PCR). On 18 December, autochthonous case infection confirmed by RT-PCR on Guiana Martinique,...
Dengue fever is the most important arboviral infection that affects humans, particularly in tropical and subtropical regions. Here, we provide first comprehensive overview of severity dengue epidemics French Guiana.We monitored hospitalized cases between 2008 2013. Detailed clinical features biological parameters were collected on a daily basis from all cases. Among 1,356 cases, 216 (16%) classified according to WHO 2009 classification as without warning signs (WS), 926 (68%) with WS 214...
We report the first complete genome sequence of Maripa virus identified in 2009 from a patient with hantavirus pulmonary syndrome French Guiana. corresponds to new variant Rio Mamoré species Bunyaviridae family, genus Hantavirus.