A5022993615- Genomics and Rare Diseases
- Skin and Cellular Biology Research
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Hearing, Cochlea, Tinnitus, Genetics
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Influenza Virus Research Studies
- RNA modifications and cancer
- Maternal and Perinatal Health Interventions
- Dermatological and Skeletal Disorders
- Magnesium in Health and Disease
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal and fetal healthcare
- Parathyroid Disorders and Treatments
- Psoriasis: Treatment and Pathogenesis
- interferon and immune responses
- RNA Research and Splicing
- BRCA gene mutations in cancer
Tel Aviv University
2016-2025
Family Research Institute
2023-2025
Harvard University
2023-2025
Clalit Health Services
2023-2025
Rabin Medical Center
2023-2025
Rafael Advanced Defense Systems (Israel)
2024-2025
Tel Aviv Sourasky Medical Center
2018-2022
Community Link
2019
Ashland (United States)
2016
Sheba Medical Center
2016
Central centrifugal cicatricial alopecia (CCCA) is the most common form of scarring among women African ancestry. The disease occasionally observed to affect in families a manner that suggests an autosomal dominant trait and usually manifests clinically after intense hair grooming. We sought determine whether there exists genetic basis CCCA and, if so, what it is.
Background Chikungunya virus (CHIKV), an alphavirus and member of the Togaviridae family, is capable causing severe febrile disease in humans. In December 2013 Asian Lineage CHIKV spread from Old World to Americas, spreading rapidly throughout New World. Given this new emergence naïve populations we studied viral genetic diversity present infected individuals understand how may have evolved during continuing outbreak. Methodology/Principle Findings We used deep-sequencing technologies...
Understanding how a pathogen colonizes and adapts to new host environment is primary aim in studying emerging infectious diseases. Adaptive mutations arise among the thousands of variants generated during RNA virus infection, identifying these will shed light onto changes tropism species jumps can occur. Here, we adapted Coxsackie B3 highly permissive less environment. Using deep sequencing bioinformatics, identified multi-step adaptive process adaptation involving residues receptor...
ABSTRACT Coronaviruses (CoVs) are unique in encoding a 3′→5′ exoribonuclease within nonstructural protein 14 (nsp14-ExoN) that is required for high-fidelity replication, likely via proofreading. nsp14 associates with the CoV RNA-dependent RNA polymerase (nsp12-RdRp), and nsp14-ExoN activity enhanced by binding nsp10, small nonenzymatic protein. However, it not known whether nsp10 functions regulation of replication fidelity. To test this, we engineered single double alanine substitution...
Canine parvovirus (CPV), a fast-evolving single-stranded DNA virus, comprises three antigenic variants (2a, 2b, and 2c) with different frequencies genetic variability among countries. The contribution of co-infection recombination to the CPV is far from being fully elucidated. Here we took advantage natural population, recently formed by convergence divergent CPV-2c CPV-2a strains, study recombination. Complete sequences viral coding region strains 40 samples were generated analyzed using...
Insertion and deletion (indel) mutations, the most common type of structural variance in human genome, affect a multitude traits diseases. New sequencing technologies, such as deep sequencing, allow massive throughput sequence data greatly contribute to field disease causing mutation detection, general, indel specifically. In order infer presence (indel calling), deep-sequencing have undergo comprehensive computational analysis. Selecting which calling software use can often skew results...
Retinitis pigmentosa (RP), the most common form of inherited retinal degeneration, is clinically and genetically heterogeneous can appear as syndromic or non-syndromic. Mucopolysaccharidosis type IIIC (MPS IIIC) a lethal disorder, caused by mutations in heparan-alpha-glucosaminide N-acetyltransferase (HGSNAT) gene characterized progressive neurological deterioration, with degeneration prominent feature. We identified HGSNAT six patients non-syndromic RP. Whole exome sequencing (WES) an...
Abstract Background MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via binding to the 3' ends of mRNAs. MiRNAs have been associated with many cellular events ascertaining their central role in regulation. In order better understand miRNAs interest it is utmost importance learn about genomic conservation these genes. Findings The miRviewer web-server, presented here, encompasses all known currently fully annotated animal genomes a visual 'birds-eye' view...
Early and accurate detection of human pathogen infection is critical for treatment therapeutics. Here we describe identification using short RNA subtraction assembly (SRSA), a method that overcomes the requirement prior knowledge culturing pathogens, by degraded small deep sequencing technology. We prove our approach's efficiency through combined viral bacterial in cells.
The inflammatory bowel diseases (IBDs) are chronic disorders, associated with genetic, immunologic, and environmental factors. Although hundreds of genes implicated in IBD etiology, it is likely that additional play a role the disease process. We developed machine learning–based gene prioritization method to identify novel IBD-risk genes. Known were collected from genome-wide association studies annotated expression pathway information. Using these genes, model was trained A comprehensive...
MicroRNAs are short non-coding RNAs that play a central role in regulation of gene-expression by binding to target-gene mRNAs. Several studies have revealed alterations cellular-miRNA profiles following HIV-1 infection, mostly inhibiting viral-infection. These miRNA expression modifications may also serve block the innate inhibition mechanism. As result, it is expected during infection miRNAs target genes hinder or prevent progression different steps replication cycle. One major sets known...
The human cytomegalovirus (HCMV) is extremely prevalent in the population. Infection by HCMV life threatening immune compromised individuals and competent it can cause severe birth defects, developmental retardation even associated with tumor development. While numerous mechanisms were developed to interfere cell activity, much less known about cellular that operate response infection. Here we demonstrate infection, expression of short form RNA editing enzyme ADAR1 (ADAR1-p110) induced. We...
Abstract Motivation: The study of RNA virus populations is a challenging task. Each population composed collection different, yet related genomes often referred to as mutant spectra or quasispecies. Virologists using deep sequencing technologies face major obstacles when studying dynamics, both experimentally and in natural settings due the relatively high error rates these lack performance pipelines. In order overcome hurdles we developed computational pipeline, termed ViVan (Viral Variance...
The mammalian inner ear contains sensory organs, the organ of Corti in cochlea and cristae maculae vestibule, with each comprised patterned epithelia that are responsible for hearing balance. development, cell fate, patterning, innervation both nonsensory regions governed by tight regulation involving, among others, transcription factors microRNAs (miRNAs). In humans, mutations specific miRNA genes associated loss. mice, experimental reduction or miRNAs leads to severe developmental...
To design a clinically based predictive model for the likelihood of successful external cephalic version (ECV).This single-center retrospective study was conducted from February 2016 to July 2018 and included all candidates ECV between 36 41 weeks gestation. Variables with potential effect on success were collected. These variables include: body mass index, amniotic fluid gestational age, parity, location placenta, fetal trunk posture, time in breech presentation before procedure...
HIV-1 is the causative agent of AIDS (Autoimmune Deficiency Syndrome). infection results in systemic CD4+ T cell depletion, thereby impairing cell-mediated immunity. MicroRNAs are short (~22 nucleotides long), endogenous single-stranded RNA molecules that regulate gene expression by binding to 3' untranslated regions (3' UTR) mRNA transcripts. The relation between and human miRNA profile has been previously investigated, studies have shown virus can alter vice versa. Here, we broaden...