A5054558447- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Hearing, Cochlea, Tinnitus, Genetics
- MicroRNA in disease regulation
- Statistical Methods in Clinical Trials
- Advanced Biosensing Techniques and Applications
- Alkaloids: synthesis and pharmacology
- SARS-CoV-2 detection and testing
- Cancer-related molecular mechanisms research
- Legal Systems and Judicial Processes
- Biosensors and Analytical Detection
- COVID-19 Clinical Research Studies
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
- vaccines and immunoinformatics approaches
- Criminal Law and Evidence
- Chemical synthesis and alkaloids
- Diet and metabolism studies
- Ear Surgery and Otitis Media
- Law, Rights, and Freedoms
- Meta-analysis and systematic reviews
- Heart Failure Treatment and Management
Ben-Gurion University of the Negev
1977-2025
College of Law
2023
Czech Academy of Sciences, Institute of Biotechnology
2022
The Technological College of Beer Sheva
2021
Tel Aviv University
2007-2014
Weizmann Institute of Science
2005
Target (United States)
2005
National Heart Lung and Blood Institute
1984-2005
National Institutes of Health
1985-2005
Stanford University
2001
In the Cardiac Arrhythmia Suppression Trial, designed to test hypothesis that suppression of ventricular ectopy after a myocardial infarction reduces incidence sudden death, patients in whom could be suppressed with encainide, flecainide, or moricizine were randomly assigned receive either active drug placebo. The use encainide and flecainide was discontinued because excess mortality. We examined mortality morbidity randomization their respective
Recent reports suggest that 10 to 30% of severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) infected patients are asymptomatic and viral shedding may occur before symptom onset. Therefore, there is an urgent need increase diagnostic testing capabilities prevent disease spread. We developed P-BEST, a method for Pooling-Based Efficient SARS-CoV-2 Testing, which identifies all positive subjects within set samples using single round testing. Each sample assigned into multiple pools...
mAbs to receptor tyrosine kinases such as EGF receptor/ErbB-1 and HER2/ErbB-2 inhibit the tumorigenic growth of certain cancer cells, but although recombinant versions Abs are already used in oncology wards, mechanism underlying immunotherapy remains unknown. We report that anti-EGF promote a slow endocytic process distinct from rapid EGF-induced internalization. Combining engage epitopes significantly accelerates degradation. In addition, mAb combinations more effective than single...
Identification of genes responsible for medically important traits is a major challenge in human genetics. Due to the genetic heterogeneity hearing loss, targeted DNA capture and massively parallel sequencing are ideal tools address this challenge. Our subjects genome analysis Israeli Jewish Palestinian Arab families with loss that varies mode inheritance severity.A custom 1.46 MB design cRNA oligonucleotides was constructed containing 246 either or mouse deafness. Paired-end libraries were...
MicroRNAs (miRNAs) inhibit the translation of target mRNAs and affect, directly or indirectly, expression a large portion protein-coding genes. This study focuses on miRNAs that are expressed in mouse cochlea vestibule, 2 inner ear compartments. A conditional knock-out for Dicer1 demonstrated crucial postnatal survival functional hair cells ear. We identified have role vertebrate developing by combining miRNA transcriptome analysis, spatial temporal patterns, bioinformatics. Microarrays...
Hereditary hearing loss is the most common sensory deficit. We determined that progressive high-frequency in 2 families of Iraqi Jewish ancestry was due to homozygosity for protein truncating mutation SYNE4 c.228delAT. SYNE4, a gene not previously associated with loss, encodes nesprin-4 (NESP4), an outer nuclear membrane (ONM) expressed hair cells inner ear. The truncated NESP4 encoded by families' did localize ONM. and SUN domain–containing 1 (SUN1), which localizes (INM), are part linker...
Vaccination, especially with multiple doses, provides substantial population-level protection against COVID-19, but emerging variants of concern (VOC) and waning immunity represent significant risks at the individual level. Here we identify correlates (COP) in a multicenter prospective study following 607 healthy individuals who received three doses Pfizer-BNT162b2 vaccine approximately six months prior to enrollment. We compared 242 fourth dose 365 did not. Within 90 days enrollment, 239...
The amyloid precursor protein (APP) is abnormally cleaved during the progression of Alzheimer's disease, resulting in production toxic beta-amyloid peptide, which forms neuritic plaques brain. To develop a pharmacological approach for treatment natural compounds may inhibit APP synthesis and/or are required. Staurosporine, toxin isolated from Streptomyces staurospores bacteria, widely used as kinase C inhibitor signal transduction research. Using rat pheochromocytoma PC12 sympathetic...
The two influenza B virus (FLUBV) lineages have continuously diverged from each other since the 1980s, with recent (post-2015) viruses exhibiting accelerated evolutionary rates. Emerging data human studies and epidemiological models suggest that increased divergence in contemporary may drive differential cross-protection, where infection Yamagata lineage provides limited immunity against Victoria viruses. Here, we developed animal to investigate mechanisms behind asymmetric cross-protection...
Mice were vaccinated by repeated subcutaneous inoculations of living, merthiolate-killed, or sonically-ruptured cells C. albicans and then challenged intravenously with 104 105 viable particles a homologous strain. Although not all the mice survived challenge, significant degree resistance was conferred since fewer deaths occurred among animals.
The mammalian inner ear contains sensory organs, the organ of Corti in cochlea and cristae maculae vestibule, with each comprised patterned epithelia that are responsible for hearing balance. development, cell fate, patterning, innervation both nonsensory regions governed by tight regulation involving, among others, transcription factors microRNAs (miRNAs). In humans, mutations specific miRNA genes associated loss. mice, experimental reduction or miRNAs leads to severe developmental...
Two patients who had previously undergone uneventful operations for strabismus showed healing of corneal dellen and erosion after withdrawal colchicine therapy. It is suggested that the exhibition therapy familial Mediterranean fever in these two cases was responsible initial persistence postoperative complications.
Vaccination and natural infection both elicit potent humoral responses that provide protection from subsequent infections. The immune history of an individual following such exposures is in part encoded by antibodies. While there are multiple immunoassays for measuring antibody responses, the majority these methods measure to a single antigen. A commonly used method ELISA-a semiquantitative assay simple perform research clinical settings. Here, we present FLU-LISA (fluorescence-linked...
Obesity is a risk factor for severe disease and mortality both influenza acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. While previous studies show that individuals with obesity generate antibody responses following vaccination, infection rates within the obese group were twice as high those in healthy-weight group. The repertoire of antibodies raised against viruses vaccinations and/or natural exposures referred to here baseline immune history (BIH). To investigate...
Abstract Variants of concern (VOC) SARS-CoV2 and waning immunity pose a serious global problem. Overall, vaccination prior infection appear to provide significant protection the majority individuals, but some remain susceptible severe disease. Rigorously identifying broad spectrum correlates (COP) is necessary identify these populations. The extent which additional booster doses also poorly understood. To address this need, we conducted multicenter prospective study assessing association...