A5080652339- Skin and Cellular Biology Research
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Plant Reproductive Biology
- Nail Diseases and Treatments
- Wnt/β-catenin signaling in development and cancer
- Dermatological and Skeletal Disorders
- Contact Dermatitis and Allergies
- Asthma and respiratory diseases
- Hair Growth and Disorders
- Autoimmune Bullous Skin Diseases
- Cellular Mechanics and Interactions
- RNA Interference and Gene Delivery
- RNA regulation and disease
- Silk-based biomaterials and applications
- Plant Surface Properties and Treatments
- Corneal Surgery and Treatments
- Dermatologic Treatments and Research
- Cell Adhesion Molecules Research
- Connexins and lens biology
- Genetic and rare skin diseases.
- melanin and skin pigmentation
- Transgenic Plants and Applications
- Advancements in Transdermal Drug Delivery
University of Dundee
2012-2021
Mountain Area Health Education Center
2020
Digital Preservation Coalition (United Kingdom)
2017
Drug Discovery Laboratory (Norway)
2017
University of Alberta
2006-2015
Pachyonychia Congenita Project
2015
University of Saskatchewan
2015
Ninewells Hospital
2002-2011
National University Hospital
2011
Our Lady's Hospital
2004-2010
Recently, loss-of-function mutations in FLG, the human gene encoding profilaggrin and filaggrin, have been identified as cause of common skin condition ichthyosis vulgaris (which is characterised by dry, scaly skin). These mutations, which are carried up to 10% people, also represent a strong genetic predisposing factor for atopic eczema, asthma allergies. Profilaggrin major component keratohyalin granules within epidermal granular cells. During terminal differentiation, approximately 400...
BackgroundAtopic dermatitis (atopic eczema) is a chronic inflammatory skin disease that has reached epidemic proportions in children worldwide and increasing prevalence. Because of the significant socioeconomic effect atopic its on quality life families, there have been decades research focused prevention, with limited success. Recent advances cutaneous biology suggest barrier defects might be key initiators possibly allergic sensitization.ObjectiveOur objective was to test whether...
BackgroundIgE-mediated peanut allergy is a complex trait with strong heritability, but its genetic basis currently unknown. Loss-of-function mutations within the filaggrin gene are associated atopic dermatitis and other diseases; therefore, candidate in etiology of allergy.ObjectiveTo investigate association between loss-of-function allergy.MethodsCase-control study 71 English, Dutch, Irish oral food challenge–positive patients 1000 non peanut-sensitized English population controls....
We describe a revised and expanded database on human intermediate filament proteins, major component of the eukaryotic cytoskeleton. The family 70 genes (including those encoding keratins, desmins, lamins) is now known to be associated with wide range diverse diseases, at least 72 distinct pathologies, including skin blistering, muscular dystrophy, cardiomyopathy, premature aging syndromes, neurodegenerative disorders, cataract. To date, catalogs 1,274 manually-curated pathogenic sequence...
BackgroundHistory and severity of atopic dermatitis (AD) are risk factors for peanut allergy. Recent evidence suggests that children can become sensitized to food allergens through an impaired skin barrier. Household consumption, which correlates strongly with protein levels in household dust, is a factor allergy.ObjectiveWe sought assess whether environmental exposure (EPE) sensitization allergy markers barrier modify this risk.MethodsPeanut dust (in micrograms per gram) was assessed highly...
Disease flares of established atopic dermatitis (AD) are generally associated with a low-diversity skin microbiota and Staphylococcus aureus dominance. The temporal transition the microbiome between early infancy dysbiosis AD is unknown.We randomly selected 50 children from Cork Babies After SCOPE: Evaluating Longitudinal Impact Using Neurological Nutritional Endpoints (BASELINE) longitudinal birth cohort for sampling at 3 points in first 6 months life 4 sites relevant to AD: antecubital...
Filaggrin, coded by FLG, is the main source of several major components natural moisturizing factor (NMF) in stratum corneum (SC), including pyrrolidone carboxylic acid (PCA) and urocanic (UCA). Loss-offunction mutations FLG lead to reduced levels filaggrin degradation products SC. It has recently been suggested that expression may additionally be influenced atopic inflammatory response. In this study, we investigated breakdown SC healthy controls (CTRL) patients with dermatitis (AD)...