A5018596294- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders
- Contact Dermatitis and Allergies
- Eosinophilic Disorders and Syndromes
- Spondyloarthritis Studies and Treatments
- Hidradenitis Suppurativa and Treatments
- Cytokine Signaling Pathways and Interactions
- Melanoma and MAPK Pathways
- Nail Diseases and Treatments
- Oral Health Pathology and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- T-cell and B-cell Immunology
- Acne and Rosacea Treatments and Effects
- Allergic Rhinitis and Sensitization
- NF-κB Signaling Pathways
- Inflammatory Myopathies and Dermatomyositis
- Cutaneous Melanoma Detection and Management
- Colorectal and Anal Carcinomas
- Hair Growth and Disorders
Universitätsmedizin Göttingen
2016-2025
University of Göttingen
2014-2023
Mössner (Germany)
2005-2022
Robert Koch Institute
2018-2022
University of Würzburg
2004-2005
Hautklinik Heidelberg
2004
Essen University Hospital
2000
Max Planck Institute for Biophysical Chemistry
1996
Because psoriatic arthritis (PsA) usually develops years after the first manifestation of skin symptoms, in many cases initial diagnosis PsA depends on dermatologist.To investigate prevalence and clinical pattern a daily practice population patients with psoriasis.Patients were enrolled an observational prospective cross-sectional cohort study at 48 community academic centres. Demographic medical parameters recorded, including severity symptoms (Psoriasis Area Severity Index, PASI), previous...
CTLA-4 and PD-1 are potential targets for tumor-induced downregulation of lymphocytic immune responses. Immune checkpoint-modifying monoclonal antibodies oppose these effects, inducing T cell-mediated responses to various tumors including melanoma. Both anti-CTLA-4 anti-PD-1 modify the interaction between tumor, antigen-presenting cells, lymphocytes. With respect overall survival, clinical studies have shown a major benefit antibody ipilimumab as well two nivolumab pembrolizumab. Following...
Rare variants in the genes IL36RN, CARD14 and AP1S3 have been identified to cause or contribute pustular skin diseases, primarily generalized psoriasis (GPP).To better understand disease relevance of these genes, we screened our cohorts patients with diseases [primarily GPP palmoplantar (PPP)] for coding changes three genes. Carriers single heterozygous IL36RN mutations were a second mutation IL36RN.Coding exons sequenced 67 - 61 GPP, two acute exanthematous pustulosis four acrodermatitis...
Generalized pustular psoriasis (GPP) is a severe multi-systemic inflammatory disease characterized by neutrophilic pustulosis and triggered pro-inflammatory IL-36 cytokines in skin. While 19%-41% of affected individuals harbor bi-allelic mutations IL36RN, the genetic cause not known most cases. To identify characterize new pathways involved pathogenesis GPP, we performed whole-exome sequencing 31 with GPP demonstrated effects MPO encoding enzyme myeloperoxidase (MPO). We discovered eight...
An association study was performed in 197 migraineurs with regard to a functional serotonin (5-HT) transporter (5-HTT) gene promoter polymorphism that leads low or high 5-HT uptake activity. The frequency of the less active short allele increased aura but not without comparison control population (<i>p</i> < 0.001). This indicates 5-HTT may be involved polygenic etiology migraine aura.
Abstract Objective Single‐nucleotide polymorphisms (SNPs) of the tumor necrosis factor gene TNF at positions −238 and −308 have been associated with psoriasis vulgaris psoriatic arthritis (PsA). The strong linkage disequilibrium (LD) chromosome region 6p21, a known to harbor risk factors for susceptibility ( PSORS1 ) other than just SNPs gene, renders interpretation these findings difficult. aim this study was analyze several its neighboring LTA independent dependent carriage allele. Methods...
Summary Background and objective Dermatophyte infections of the skin nails are common worldwide vary between geographical areas over time. The aim this study was to determine epidemiological profile dermatophytes in Germany with a focus on comparing children adults. Patients methods In retrospective multicenter study, mycological dermatophyte culture results period 01/2014 12/2016 were analyzed according identified pathogen, age gender patients, type disease. Results Of 1,136 (children: n =...