A5046052287- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Spondyloarthritis Studies and Treatments
- Management of metastatic bone disease
- Cerebrospinal fluid and hydrocephalus
- S100 Proteins and Annexins
- Glioma Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Medical Practices and Rehabilitation
- Psoriasis: Treatment and Pathogenesis
- Neurosurgical Procedures and Complications
- Cervical and Thoracic Myelopathy
- Intracerebral and Subarachnoid Hemorrhage Research
- Sulfur Compounds in Biology
- Medical Imaging and Analysis
- Pelvic and Acetabular Injuries
- Blood Coagulation and Thrombosis Mechanisms
- Medical and Health Sciences Research
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Nitric Oxide and Endothelin Effects
- Health and Medical Studies
- Criminal Law and Policy
- Fibromyalgia and Chronic Fatigue Syndrome Research
Klinikum Osnabrück
2012-2023
Gesellschaft fuer Wirtschaftliche Strukturforschung
2023
Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie
2014
Universitätsklinikum Gießen und Marburg
2006
Justus-Liebig-Universität Gießen
1994-2004
University of Applied Sciences Mainz
2004
Clinical Research Center Kiel
2004
Medical University of Vienna
2002
Ruhr University Bochum
1990-1996
Universitätsklinikum Knappschaftskrankenhaus Bochum
1989-1993
Abstract: In previous studies, it had been shown that human gray and white matter tissue slices have the capacity to synthesize large amounts of cysteinyl‐leukotrienes (cysteinyl‐LT) in vitro. This study was initiated investigate cysteinyl‐LT formation by from intracranial tumors comparison with cyclooxygenase products such as prostaglandin (PG) F 2α , thromboxane (TX) B 2 . Tissue meningiomas astrocytomas were found release spontaneously even higher after ionophore A 23187 stimulation,...
Elderly patients with idiopathic trigeminal neuralgia are commonly referred to percutaneous treatment if medical therapy has failed. Due elaborated microsurgical techniques and perioperative care, minimal invasive neurosurgical operations like microvascular decompression (MVD) can be offered increasingly elderly patients. We operated upon 8 (median 70.5 years) suffering from using MVD in a one-year period (1995). Seven were free of pain at release. At two year follow-up, 2 reported slight...
Disturbed autoregulation and CO2 reactivity have been reported in patients with brain tumors. Therefore, we decided to monitor the cerebrovascular effects of anesthetic drugs hyperventilation. Transcranial Doppler sonography (TCD) can measure noninvasively alterations flow velocities (v) cross-sectional vessel area (VA) large arteries. Twenty-eight malignant tumors territory middle cerebral artery (MCA) randomly received propofol or thiopental for induction maintenance anesthesia. Mean...
In 12 operatively (stereotactic aspiration and recombinant tissue-type plasminogen activator, rTPA) 5 conservatively treated patients with spontaneous intracerebral hemorrhage the amounts of cysteinyl-leukotriene (cys-LT) released by blood-brain cell contact were measured urinary excretion their metabolites during treatment. The mean cys-LT release before treatment was 14.51 ± 1.13 pg/mg creatinine/ml hematoma volume. at end measurements significantly lower in group than conservative therapy...
In rare cases the peritoneal catheter of a ventriculoperitoneal shunt dislodges from valve and tube migrates into cavity. For retrieval free intraperitoneal shunt, laparoscopy is initial method choice.
The purpose of this study was to identify the trigger mechanism activating 5-lipoxygenase pathway during blood–brain cell contact and estimate contribution blood brain cells cysteinyl–leukotriene (LT) biosynthesis observed under these conditions. Incubation dissociated rat in Krebs-Henseleit solution for up 60 min did not stimulate any detectable cysteinyl–LT biosynthesis. recalcified whole vitro led release only small amounts into serum samples. However, coincubation with physiologically...
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Cortical bone trajectory (CBT) is a relatively new technique for pedicle screw insertion in the field of spine surgery. Previous studies have demonstrated significantly better pullout and toggle characteristics method offers, it appears to certain advantages over widely used traditional trajectory. The mechanism still remains unknown. To report medium- long-term follow-up findings patients who underwent posterior lumbar interbody fusion or (PLIF/PLF) at our institution discuss ideal when...
AbstractAbstractIn glioblastoma patients dexamethasone is routinely administered as an antiedematous drug. In contrast to its empirically proven effect, the biochemical way of action remains poorly understood. order assess whether a direct cytotoxic effect present in vivo we compared levels brain tumor specimens with concentrations cell culture. Biopsy were taken during microsurgical removal, homogenized and measured by high pressure liquid chromatography. culture tested different on A172,...
Background: Chiari malformation type I is a stenosis of the subarachnoid space at level foramen magnum due to small posterior fossa and herniation cerebellar tonsils. We present here unusual case in conjunction with persistent trigeminal artery hypoplasia basilar artery, also known as Saltzman anomaly. Case Report: A 34-year-old female physician presented recurrent headaches, bilateral weakness deltoid muscles numbness fingertips 3 5. cranial MRI revealed descent tonsils C2 supracerebellar...
Abstract Introduction Far-reaching political steps to contain the COVID-19 pandemic have been undertaken in recent weeks. These also impact on surgical specialties not directly involved management of patients infected with coronavirus. The Spine Section, interdisciplinary professional arm German Society (DWG), Professional Association for Orthopedic and Trauma Surgery (BVOU), Federal Neurosurgeons (BDNC) conducted a survey collateral effects spine surgery Germany. Method This cross-sectional...