Juliet N. Barker
A5071626276- Psoriasis: Treatment and Pathogenesis
- Hematopoietic Stem Cell Transplantation
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- Acute Myeloid Leukemia Research
- Cytomegalovirus and herpesvirus research
- Acute Lymphoblastic Leukemia research
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Autoimmune Bullous Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Transplantation: Methods and Outcomes
- Mesenchymal stem cell research
- Monoclonal and Polyclonal Antibodies Research
- Pharmaceutical studies and practices
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Cell Adhesion Molecules Research
- Health Systems, Economic Evaluations, Quality of Life
- Immunotherapy and Immune Responses
- Urticaria and Related Conditions
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
King's College London
2016-2025
Guy's and St Thomas' NHS Foundation Trust
2016-2025
National Health Service
2019-2025
Samsung (United States)
2025
Pfizer (United Kingdom)
2015-2025
Novartis (Switzerland)
2025
Bristol-Myers Squibb (Germany)
2025
Almirall (Spain)
2025
Boehringer Ingelheim (India)
2025
NIHR Manchester Biomedical Research Centre
2025
The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing diverse individuals from multiple populations. Here we report completion the project, having reconstructed genomes 2,504 26 populations using combination low-coverage sequencing, deep exome and dense microarray genotyping. We characterized broad spectrum variation, in total over 88 million variants (84.7 single nucleotide polymorphisms (SNPs), 3.6...
Data regarding the outcome of cord-blood transplantation in adults are scant, despite fact that these grafts increasingly used adults.
Umbilical-cord blood from unrelated donors who are not HLA-identical with the recipients can restore hematopoiesis after myeloablative therapy in children. We studied use of transplantation umbilical-cord to adults.
JEADV october 2009, volume 23, supplement 2 European S3-Guidelines on the systemic treatment of psoriasis vulgaris D Pathirana, AD Ormerod, P Saiag, C Smith, PI Spuls, A Nast, J Barker, JD Bos, G-R Burmester, S Chimenti, L Dubertret, B Eberlein, R Erdmann, Ferguson, G Girolomoni, Gisondi, Giunta, Griffiths, H Hönigsmann, M Hussain, Jobling, S-L Karvonen, Kemeny, I Kopp, Leonardi, Maccarone, Menter, U Mrowietz, Naldi, T Nijsten, J-P Ortonne, H-D Orzechowski, Rantanen, K Reich, N Reytan,...
The relationship between intestinal microbiota composition and acute graft-versus-host disease (GVHD) after allogeneic blood/marrow transplantation (allo-BMT) is not well understood. Intestinal bacteria have long been thought to contribute GVHD pathophysiology, but recent animal studies in nontransplant settings found that anti-inflammatory effects are mediated by certain subpopulations of commensals. Hypothesizing a more nuanced may exist the GVHD, we evaluated fecal bacterial 64 patients...
Relationships between microbiota composition and clinical outcomes after allogeneic hematopoietic-cell transplantation have been described in single-center studies. Geographic variations the of human microbial communities differences practices across institutions raise question whether these associations are generalizable.
Psoriasis is a common chronic inflammatory disorder of the skin. To further understand pathogenesis psoriasis we have chosen to investigate molecular genetic basis disorder. We used two-stage approach search human genome for location genes conferring susceptibility psoriasis, using total 106 affected sibling pairs identified from 68 independent families. As over third extended kindreds included relatives besides siblings, in addition an analysis allele sharing between pairs, novel linkage...
High-throughput screening against the human sirtuin SIRT1 led to discovery of a series indoles as potent inhibitors that are selective for over other deacetylases and NAD-processing enzymes. The most compounds described herein inhibit with IC50 values 60-100 nM, representing 500-fold improvement previously reported SIRT inhibitors. Preparation enantiomerically pure indole derivatives allowed their characterization in vitro vivo. Kinetic analyses suggest these bind after release nicotinamide...
Psoriasis is a common, chronic inflammatory skin disease which typically follows relapsing and remitting course, associated with joint in approximately 25% of patients.1 The significant reduction quality life the psychosocial disability suffered by patients underline need for prompt, effective treatment, long-term control (reviewed2, 3). Localized, limited can usually be managed satisfactorily topical agents. Those moderate to severe often require systemic treatment. Phototherapy traditional...