Tianming Lan
A5024331115- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Genetic and phenotypic traits in livestock
- Single-cell and spatial transcriptomics
- Amphibian and Reptile Biology
- Chromosomal and Genetic Variations
- Forensic and Genetic Research
- Molecular Biology Techniques and Applications
- Venomous Animal Envenomation and Studies
- SARS-CoV-2 and COVID-19 Research
- Helminth infection and control
- Parasite Biology and Host Interactions
- Antimicrobial Peptides and Activities
- Insect symbiosis and bacterial influences
- Genetic Associations and Epidemiology
- Aquaculture disease management and microbiota
- Genetic Mapping and Diversity in Plants and Animals
- Wildlife Ecology and Conservation
- Nutrition, Genetics, and Disease
- SARS-CoV-2 detection and testing
- Cancer-related molecular mechanisms research
- Environmental DNA in Biodiversity Studies
- Parasites and Host Interactions
- Parasitic Infections and Diagnostics
- Identification and Quantification in Food
BGI Group (China)
2015-2025
Northeast Forestry University
2021-2025
Guangdong Academy of Forestry
2025
Agricultural Genomics Institute at Shenzhen
2022-2024
University of Copenhagen
2020-2024
Zhejiang University
2024
Huangshan University
2023
BGI Research
2023
Anhui Normal University
2023
University of Chinese Academy of Sciences
2021
The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing diverse individuals from multiple populations. Here we report completion the project, having reconstructed genomes 2,504 26 populations using combination low-coverage sequencing, deep exome and dense microarray genotyping. We characterized broad spectrum variation, in total over 88 million variants (84.7 single nucleotide polymorphisms (SNPs), 3.6...
Abstract The fall armyworm (FAW), Spodoptera frugiperda , is a destructive pest native to America and has recently become an invasive insect in China. Because of its rapid spread great risks China, understanding FAW genetic background pesticide resistance urgent essential develop effective management strategies. Here, we assembled chromosome-level genome male (SFynMstLFR) compared re-sequencing results the populations from America, Africa, Strain identification 163 individuals collected...
The availability of viral entry factors is a prerequisite for the cross-species transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening animal cells could reveal expression patterns genes in different hosts. However, such exploration SARS-CoV-2 remains limited. Here, we perform single-nucleus RNA sequencing 11 non-model species, including pets (cat, dog, hamster, and lizard), livestock (goat rabbit), poultry (duck pigeon), wildlife...
Goats are one of the most widespread farmed animals across world; however, their migration route to East Asia and local evolutionary history remain poorly understood. Here, we sequenced 27 ancient Chinese goat genomes dating from Late Neolithic period Iron Age. We found close genetic affinities between modern goats, demonstrating continuity. that goats originated eastern regions around Fertile Crescent, estimated ancestors diverged this population in Chalcolithic period. Modern were divided...
Abstract The South China tiger ( Panthera tigris amoyensis , SCT) is the most critically endangered subspecies of due to functional extinction in wild. Inbreeding depression observed among captive population descended from six wild ancestors, resulting high juvenile mortality and low reproduction. We assembled characterized first SCT genome an improved Amur P. t. altaica AT) named AmyTig1.0 PanTig2.0. two genomes are continuous comprehensive any yet reported at chromosomal level. By using...
Abstract Next-generation sequencing provides a high-resolution insight into human genetic information. However, the focus of previous studies has primarily been on low-coverage data due to high cost sequencing. Although 1000 Genomes Project and Haplotype Reference Consortium have both provided powerful reference panels for imputation, low-frequency novel variants remain difficult discover call with accuracy basis data. Deep an optimal solution problem these variants. whole-exome is also...
Abstract The fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith) is a severely destructive pest native to the Americas, but has now become an alien invasive in China, and causes significant economic loss. Therefore, order make effective management strategies, it highly essential understand genomic architecture its genetic background. In this study, we assembled two chromosome scale genomes of armyworm, representing one male female individual procured from Yunnan province China. genome...
Poaching and trafficking have a substantial negative impact on the population growth range expansion of Chinese pangolin (Manis pentadactyla). However, recently reported activities pangolins in several sites Guangdong province China indicate promising sign for recovery this threatened species. Here, we re-sequence genomes 15 individuals perform comprehensive genomics analyses with previously published 22 individuals. These are found to be divided into three distinct populations. Multiple...
The extinction risk of the giant panda has been demoted from “endangered” to “vulnerable” on International Union for Conservation Nature Red List, but its habitat is more fragmented than ever before, resulting in 33 isolated populations according fourth national survey released by Chinese government. Further comprehensive investigations genetic background and in-depth assessments conservation status wild are still necessary urgently needed. Here, we sequenced genomes 612 pandas with an...
The formation of animal breeds usually begins with a small subsample from their ancestral population. Deleterious mutations accumulate in the population under genetic drift, inbreeding, and artificial selection during development maintenance traits desired by humans. White raccoon dogs are among most popular farmed dogs, but white more susceptible to disease have lower reproductive ability. However, accumulation deleterious this breed is largely unknown. By analyzing comparing whole-genome...
A high-quality reference genome coupled with resequencing data is a promising strategy to address issues in conservation genomics. This has greatly enhanced the development of plans for endangered species. Pangolins are fascinating animals variety unique features. Unfortunately, they most trafficked wild animal world. In this study, we assembled chromosome-scale HiFi long reads and Hi-C short Chinese Malayan pangolin provided two new representative genomes We found great improvement...
<title>Abstract</title> The Western nose-horned viper (<italic>Vipera ammodytes ammodytes</italic>) is the most venomous snake in Europe, known for its potent venom and danger it poses to humans. To better understand genetic architecture behind composition ecological adaptations, we assembled a high-quality <italic>de novo</italic> chromosomal-level genome this species. Using combination of PacBio Illumina sequencing, achieved 131x coverage, surpassing previous assemblies. Our analysis...
The large scale genome wide association studies (GWAS) have identified approximately 80 single nucleotide polymorphisms (SNPs) conferring susceptibility to type 2 diabetes (T2D). However, most of these loci not been replicated in diverse populations and much genetic heterogeneity has observed across ethnic groups. We tested 28 SNPs previously found be associated with T2D by GWAS a Mongolian sample Northern China (497 diagnosed 469 controls) for related quantitative traits. 11 SNPs, namely,...
Abstract A few animals have been suspected to be intermediate hosts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a large-scale single-cell screening SARS-CoV-2 target cells on wide variety is missing. Here, we constructed the atlas for 11 representative species in pets, livestock, poultry, and wildlife. Notably, proportion cat was found considerably higher than other investigated were detected multiple cell types domestic pig, implying necessity carefully...
Mongolians have played a significant role in modern human evolution, especially after the rise of Genghis Khan (1162[?]–1227). Although social cultural impacts and Mongolian population been well documented, explorations their genome structure genetic imprints on other populations lacking. We here present male individual. The was de novo assembled using total 130.8-fold genomic data produced from massively parallel whole-genome sequencing. identified high-confidence variation sets, including...
Extant giant pandas are divided into Sichuan and Qinling subspecies. The panda has many species-specific characteristics, including comparatively small organs for body size, genitalia of male individuals, low reproduction. Here, we report the most contiguous, high-quality chromosome-level genomes two extant subspecies to date, with first genome assembly Compared previously assembled based on short reads, our increased contiguity over 200-fold at contig level. Additional sequencing 25...
The raccoon dog (Nyctereutes procyonoides) is an invasive canid species native to East Asia with several distinct characteristics. Here, we report a chromosome-scale genome of the high contiguity, completeness, and accuracy. intact taste receptor genes, expanded gene families, positively selected genes related digestion, absorption, foraging, detoxification likely support omnivory dogs. Several dog-specific mutations in TDRD6 ZP3 may explain their reproductivity. Enriched GO terms energy...
Abstract The Proboscidea, which includes modern elephants, were once the largest terrestrial animals among extant species. They suffered mass extinction during Ice Age. As a unique branch on evolutionary tree, Proboscidea are of great significance for study living animals. In this study, we generate chromosome-scale and haplotype-resolved genome assemblies two species (Asian Elephant, Elephas maximus African Savannah Loxodonta africana ) using Pacbio, Hi-C, DNBSEQ technologies. assembled...
Abstract Critically endangered species are usually restricted to small and isolated populations. High inbreeding without gene flow among populations further aggravates their threatened condition reduces the likelihood of long‐term survival. Chinese alligator ( Alligator sinensis ) is one most crocodiles in world has experienced a continuous decline over past c. 1 million years. In order identify genetic status remaining aid conservation efforts, we assembled first high‐quality...
The green peafowl (Pavo muticus) is facing a high risk of extinction due to the long-term and widespread threats poaching habitat conversion. Here, we present high-quality chromosome-level genome assembly with contiguity accuracy assembled by PacBio sequencing, DNBSEQ short-read Hi-C sequencing technologies. final size was estimated be 1.049 Gb, whereas 1.042 Gb assigned 27 pseudochromosomes. scaffold N50 length 75.5 Mb complete BUSCO score 97.6%. We identified W Z chromosomes validated them...