Peiwen Ding
A5031453925- Single-cell and spatial transcriptomics
- SARS-CoV-2 and COVID-19 Research
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Congenital heart defects research
- Advanced biosensing and bioanalysis techniques
- Animal Virus Infections Studies
- Bat Biology and Ecology Studies
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Viral Infections and Vectors
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Protease and Inhibitor Mechanisms
- Gene Regulatory Network Analysis
- Hematopoietic Stem Cell Transplantation
- Poxvirus research and outbreaks
- Viral gastroenteritis research and epidemiology
- Cell Image Analysis Techniques
- Gene expression and cancer classification
- CRISPR and Genetic Engineering
- Neurogenesis and neuroplasticity mechanisms
- Studies on Chitinases and Chitosanases
First Affiliated Hospital of Harbin Medical University
2025
Harbin Medical University
2025
Chengdu University of Traditional Chinese Medicine
2023
University of Chinese Academy of Sciences
2019-2022
BGI Group (China)
2019-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Suzhou Institute of Systems Medicine
2022
China Railway First Survey and Design Institute Group Co. Ltd.
2022
Northwest University
2022
China Railway Fifth Survey and Design Institute Group
2022
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks especially in those patients without comorbidities, not fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude with selected yet symptoms ranging asymptomatic critically ill. Using integrative analysis genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, report...
Abstract Pigs are valuable large animal models for biomedical and genetic research, but insights into the tissue- cell-type-specific transcriptome heterogeneity remain limited. By leveraging single-cell RNA sequencing, we generate a multiple-organ transcriptomic map containing over 200,000 pig cells from 20 tissues/organs. We comprehensively characterize of in tissues identify 234 cell clusters, representing 58 major types. In-depth integrative analysis endothelial reveals high degree...
The availability of viral entry factors is a prerequisite for the cross-species transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening animal cells could reveal expression patterns genes in different hosts. However, such exploration SARS-CoV-2 remains limited. Here, we perform single-nucleus RNA sequencing 11 non-model species, including pets (cat, dog, hamster, and lizard), livestock (goat rabbit), poultry (duck pigeon), wildlife...
Abstract It is a challenge to efficiently integrate and present the tremendous amounts of single-cell data generated from multiple tissues various species. Here, we create new database named SPEED for pan-species atlas in light ecology evolution development diseases (freely accessible at http://8.142.154.29 or http://speedatlas.net). an online platform with 4 modules, 7 function modules 2 display modules. The ‘Pan’ module applied interactive analysis single cell sequencing datasets 127...
The brain of the domestic pig (Sus scrofa domesticus) has drawn considerable attention due to its high similarities that humans. However, cellular compositions (PB) remain elusive. Here we investigated single-nucleus transcriptomic profiles five regions PB (frontal lobe, parietal temporal occipital and hypothalamus) identified 21 cell subpopulations. cross-species comparison mouse hypothalamus revealed shared specific gene expression patterns at single-cell resolution. Furthermore, types...
Minimal residual disease (MRD) monitoring has been demonstrated to important in predicting prognosis acute myeloid leukemia (AML) receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT), but the ideal time point and method remain unclear. Our study compared prognostic value of multiparameter flow cytometry (MFC)-based WT1 expression-based MRD a month before allo-HSCT [HSCT(-1 m)] after [HSCT(+ 1 m)], as well next generation sequencing (NGS)-based at HSCT(-1 m), HSCT(+ 3 6...
Abstract A few animals have been suspected to be intermediate hosts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a large-scale single-cell screening SARS-CoV-2 target cells on wide variety is missing. Here, we constructed the atlas for 11 representative species in pets, livestock, poultry, and wildlife. Notably, proportion cat was found considerably higher than other investigated were detected multiple cell types domestic pig, implying necessity carefully...
Viral infectious diseases are a devastating and continuing threat to human animal health. Receptor binding is the key step for viral entry into host cells. Therefore, recognizing receptors fundamental understanding potential tissue tropism or range of these pathogens. The rapid advancement single-cell RNA sequencing (scRNA-seq) technology has paved way studying expression in different tissues species at resolution, resulting huge scRNA-seq datasets. However, effectively integrating sharing...
Understanding the phenotypic and functional diversity of cerebral cortical GABAergic neurons requires a comprehensive analysis key transcriptional signatures neuronal subtype identity. However, conservation across multiple mammals remain unclear. Here, we collected single-nucleus RNA sequencing (snRNA-seq) datasets cortex from human, macaque, mouse, pig to identify conserved cell types species. After systematic heterogeneity neurons, defined four major neuron subclasses (Inc SST, Inc LAMP5,...
Olfaction, the sense of smell, is a fundamental trait crucial to many species. The olfactory bulb (OB) plays pivotal roles in processing and transmitting odor information from environment brain. cellular heterogeneity mouse OB has been studied using single-cell RNA sequencing. However, epigenetic landscape mOB remains mostly unexplored. Herein, we apply assay for transposase-accessible chromatin sequencing profile genome-wide accessibility 9,549 single cells mOB. Based on signatures, are...
Summary System-wide molecular characteristics of COVID-19, especially in those patients without comorbidities, have not been fully investigated. We compared extensive profiles blood samples from 231 COVID-19 patients, ranging asymptomatic to critically ill, importantly excluding with any comorbidities. Amongst the major findings, were characterized by highly activated anti-virus interferon, T/natural killer (NK) cell activation, and transcriptional upregulation inflammatory cytokine mRNAs....
Abstract The outbreak of coronavirus disease 2019 (COVID-19) has been causing a global health emergency. Although previous studies investigated COVID-19 at different omics levels, the molecular hallmarks COVID-19, especially in those patients without comorbidities, have not fully investigated. Here, we presented trans-omics landscape for based on integrative analysis genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles from blood samples 231 patients, ranging asymptomatic...
ABSTRACT Horseshoe bats ( Rhinolophus sinicus ) might help maintain coronaviruses severely affecting human health, such as SARS-CoV and SARS-CoV-2. It has long been suggested that may be more tolerant of viral infection than other mammals due to their unique immune system, but the exact mechanism remains fully explored. During COVID-19 pandemic, multiple animal species were diseased by SARS-CoV-2 infection, especially in respiratory system. Herein, single-cell transcriptomic data lungs a...
Grassroots environmental protection agencies are the “last kilometer” of supervision in China, but effects these have not received sufficient attention from economic community. This paper adopts synthetic control method to estimate impact establishing grassroots on industrial pollution discharge. The results show that reduces discharge, only statistically significant some regions. In addition, do significantly local growth and structure. generally problems such as inadequate managerial...
Abstract Down syndrome (DS) is one of the most common human birth defects caused by trisomy 21 (T21), leading to a variety cognitive impairments. The cellular composition brain has been explored using single cell RNA sequencing in both physiological and pathological conditions. However, heterogeneity with chromosome aneuploidy largely unknown. Here, we profiled transcriptome 36046 cells cerebral cortex T21 fetus, covering frontal lobe, parietal occipital lobe temporal lobe. Intriguingly,...