A5023131329- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- SARS-CoV-2 and COVID-19 Research
- Single-cell and spatial transcriptomics
- Genetic and phenotypic traits in livestock
- Plant biochemistry and biosynthesis
- Antimicrobial Peptides and Activities
- SARS-CoV-2 detection and testing
- Gut microbiota and health
- Probiotics and Fermented Foods
- Biodiesel Production and Applications
- Chromosomal and Genetic Variations
- Advanced Photocatalysis Techniques
- Aquaculture disease management and microbiota
- Clostridium difficile and Clostridium perfringens research
- Insect symbiosis and bacterial influences
- Catalytic Processes in Materials Science
- Animal Virus Infections Studies
- Seed Germination and Physiology
- Gastrointestinal motility and disorders
- Soil Management and Crop Yield
- Oil Palm Production and Sustainability
- Artificial Intelligence in Healthcare
- Advanced oxidation water treatment
- Agricultural Economics and Practices
Peking University Shenzhen Hospital
2025
BGI Group (China)
2020-2022
University of Chinese Academy of Sciences
2020-2022
Agricultural Genomics Institute at Shenzhen
2022
University of Copenhagen
2021
Zhejiang University
2015-2021
University of California, San Diego
2021
Shaanxi University of Science and Technology
2021
Zhejiang Shuren University
2020
Fujian Medical University
2017
We selected 42 early-stage primary biliary cirrhosis (PBC) patients and 30 healthy controls (HC). Metagenomic sequencing of the 16S rRNA gene was used to characterize fecal microbiome. UPLC-MS/MS assaying small molecules metabolomes serum, urine feces. Liquid chip serum cytokines immune profiles. The gut PBC were depleted some potentially beneficial bacteria, such as Acidobacteria, Lachnobacterium sp., Bacteroides eggerthii Ruminococcus bromii, but enriched in bacterial taxa containing...
Abstract Between March and June, 2013, forty H7N9 patients were hospitalized in our hospital. Next-generation sequencing technologies have been used to sequence the fecal DNA samples of patient, within sample diversity analysis, enterotyping, functional gene metagenomic species analysis carried on both healthy controls. The influence associated treatment infected is dramatic was firstly revealed level due deep technology. We found that most MetaGenomic Species (MGS) enriched control...
The availability of viral entry factors is a prerequisite for the cross-species transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening animal cells could reveal expression patterns genes in different hosts. However, such exploration SARS-CoV-2 remains limited. Here, we perform single-nucleus RNA sequencing 11 non-model species, including pets (cat, dog, hamster, and lizard), livestock (goat rabbit), poultry (duck pigeon), wildlife...
Abstract The South China tiger ( Panthera tigris amoyensis , SCT) is the most critically endangered subspecies of due to functional extinction in wild. Inbreeding depression observed among captive population descended from six wild ancestors, resulting high juvenile mortality and low reproduction. We assembled characterized first SCT genome an improved Amur P. t. altaica AT) named AmyTig1.0 PanTig2.0. two genomes are continuous comprehensive any yet reported at chromosomal level. By using...
Abstract Objective This study aimed to evaluate the predictive value of implementing machine learning models based on ultrasound radiomics and clinicopathological features in survival analysis triple-negative breast cancer (TNBC) patients. Methods materials All patients, including retrospective cohort (training cohort, n = 306; internal validation 77) prospective external ( 82), were diagnosed as locoregional TNBC underwent pre-intervention sonographic evaluation this multi-center study. A...
Rubber seed oil, derived from the seeds of rubber tree – Hevea brasiliensis, has been shown as a viable option for biodiesel production. However, few studies have investigated factors influencing yield. This study evaluates yield through in situ counting dominant clones (RRIM600# and GT1#) Xishuangbanna, China. Comparisons across age classes along an elevation gradient were carried out. The survey was then used predictor potential oil production, both locally regionally, calculates...
Poaching and trafficking have a substantial negative impact on the population growth range expansion of Chinese pangolin (Manis pentadactyla). However, recently reported activities pangolins in several sites Guangdong province China indicate promising sign for recovery this threatened species. Here, we re-sequence genomes 15 individuals perform comprehensive genomics analyses with previously published 22 individuals. These are found to be divided into three distinct populations. Multiple...
Mosses compose one of the three lineages bryophytes. Today, about 13,000 species mosses are recognized from across globe, and at least one-third this diversity composes Hypnales, a lineage characterized by an early rapid radiation. We sequenced de novo assembled genomes two hypnalean mosses, namely Entodon seductrix Hypnum curvifolium, based on 10x genomics Hi-C data. The genome assemblies E. H. curvifolium comprise 348.4 262.0 Mb, respectively, estimated k-mer analyses to represent 93.3%...
Abstract A few animals have been suspected to be intermediate hosts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a large-scale single-cell screening SARS-CoV-2 target cells on wide variety is missing. Here, we constructed the atlas for 11 representative species in pets, livestock, poultry, and wildlife. Notably, proportion cat was found considerably higher than other investigated were detected multiple cell types domestic pig, implying necessity carefully...
The raccoon dog (Nyctereutes procyonoides) is an invasive canid species native to East Asia with several distinct characteristics. Here, we report a chromosome-scale genome of the high contiguity, completeness, and accuracy. intact taste receptor genes, expanded gene families, positively selected genes related digestion, absorption, foraging, detoxification likely support omnivory dogs. Several dog-specific mutations in TDRD6 ZP3 may explain their reproductivity. Enriched GO terms energy...
Although the pathologic investigation of liver injury was observed in a couple cases China, detailed description histopathologic and ultrastructural changes relatively larger series tissues from COVID-19 patients is lacking. Samples were obtained 24 February 1 to April 1, 2020. Light microscopy showed that all sections had different degrees manifested as swelling hepatocytes, hepatocellular necrosis, steatosis, lobular inflammation, portal dilatation sinusoids, so on. SARS-CoV-2 induced...
The green peafowl (Pavo muticus) is facing a high risk of extinction due to the long-term and widespread threats poaching habitat conversion. Here, we present high-quality chromosome-level genome assembly with contiguity accuracy assembled by PacBio sequencing, DNBSEQ short-read Hi-C sequencing technologies. final size was estimated be 1.049 Gb, whereas 1.042 Gb assigned 27 pseudochromosomes. scaffold N50 length 75.5 Mb complete BUSCO score 97.6%. We identified W Z chromosomes validated them...
Abstract Critically endangered species are usually restricted to small and isolated populations. High inbreeding without gene flow among populations further aggravates their threatened condition reduces the likelihood of long‐term survival. Chinese alligator ( Alligator sinensis ) is one most crocodiles in world has experienced a continuous decline over past c. 1 million years. In order identify genetic status remaining aid conservation efforts, we assembled first high‐quality...
Viral infectious diseases are a devastating and continuing threat to human animal health. Receptor binding is the key step for viral entry into host cells. Therefore, recognizing receptors fundamental understanding potential tissue tropism or range of these pathogens. The rapid advancement single-cell RNA sequencing (scRNA-seq) technology has paved way studying expression in different tissues species at resolution, resulting huge scRNA-seq datasets. However, effectively integrating sharing...
Helminth diseases have long been a threat to the health of humans and animals. Roundworms are important organisms for studying parasitic mechanisms, disease transmission prevention. The study parasites in giant panda is importance understanding how roundworms adapt host. Here, we report high-quality chromosome-scale genome Baylisascaris schroederi with size 253.60 Mb 19,262 predicted protein-coding genes. We found that gene families related epidermal chitin synthesis environmental...
The masked palm civet (Paguma larvata) is a small carnivore with distinct biological characteristics, that likes an omnivorous diet and also serves as vector of pathogens. Although this species not endangered animal, its population reportedly declining. Since the severe acute respiratory syndrome (SARS) epidemic in 2003, public has been particularly concerned about species. Here, we present first genome P. larvata, comprising 22 chromosomes assembled using single-tube long fragment read...
// Yixin Zhu 1, * , Weijin Yang 2, 3, Guangnian Ji 4, Nan Lin 3 Weihang Wu Ping Xiong 1 Chenxin Zheng Lei Yan Peng Wan Yu Wang Clinical Institute of Fuzhou General Hospital, Fujian Medical University, Fuzhou, 350025, China 2 Department Surgery, Dongfang Xiamen 4 Hospital Affiliated to Xiamen, 361005, These authors contributed equally this work as co-first Correspondence to: Wang, email: flyfishwang@hotmail.com Keywords: BRD4, gastric adenocarcinoma, surgical resection, predictor, prognosis...
We report a draft genome sequence of Lactobacillus panis DSM 6035(T), isolated from sourdough. The this strain is 2,082,789 bp long, with 47.9% G+C content. A total 2,047 protein-coding genes were predicted.
The coronavirus disease 19 (COVID-19) is caused by severe acute respiratory syndrome 2 (SARS-CoV-2), and the outbreak has rapidly spread worldwide causing a global pneumonia pandemic. Several animals have been proven to be affected SARS-CoV-2, posing an enormous threat humans. However, confirm intermediate hosts in epidemic regions, it unrealistic detect its presence each every animal one one. An active transmembrane serine protease (TMPRSS2) which functions priming of S-protein SARS-CoV-2...