A5100904920- Healthcare Technology and Patient Monitoring
- ECG Monitoring and Analysis
- Non-Invasive Vital Sign Monitoring
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Single-cell and spatial transcriptomics
- Quality and Safety in Healthcare
- Radio Frequency Integrated Circuit Design
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Video Surveillance and Tracking Methods
- Advanced Power Amplifier Design
- Extracellular vesicles in disease
- Cardiac, Anesthesia and Surgical Outcomes
- Cell Image Analysis Techniques
- COVID-19 diagnosis using AI
- Health Promotion and Cardiovascular Prevention
- Sepsis Diagnosis and Treatment
- Reproductive System and Pregnancy
- CRISPR and Genetic Engineering
- Machine Learning in Healthcare
- Inflammasome and immune disorders
- Acute Ischemic Stroke Management
- Human Pose and Action Recognition
- Immune Cell Function and Interaction
- Time Series Analysis and Forecasting
Shanghai University of Sport
2025
Hubei University of Medicine
2024-2025
Hainan University
2020-2025
BGI Group (China)
2020-2024
BGI Research
2024
Chongqing Normal University
2024
Shanghai Micro Satellite Engineering Center
2023
Zhejiang University
2023
Beilstein-Institut
2023
China National GeneBank
2022
Purpose Physiologic monitors are plagued with alarms that create a cacophony of sounds and visual alerts causing “alarm fatigue” which creates an unsafe patient environment because life-threatening event may be missed in this milieu sensory overload. Using state-of-the-art technology acquisition infrastructure, all monitor data including 7 ECG leads, pressure, SpO2, respiration waveforms as well user settings were stored on 461 adults treated intensive care units. well-defined alarm...
Abstract The COVID-19 pandemic has accounted for millions of infections and hundreds thousand deaths worldwide in a short-time period. patients demonstrate great diversity clinical laboratory manifestations disease severity. Nonetheless, little is known about the host genetic contribution to observed interindividual phenotypic variability. Here, we report first study Chinese population by deeply sequencing analyzing 332 categorized varying levels severity from Shenzhen Third People’s...
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks especially in those patients without comorbidities, not fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude with selected yet symptoms ranging asymptomatic critically ill. Using integrative analysis genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, report...
Abstract Preeclampsia is a multifactorial and heterogeneous complication of pregnancy. Here, we utilize single-cell RNA sequencing to dissect the involvement circulating immune cells in preeclampsia. Our findings reveal downregulation response lymphocyte subsets preeclampsia, such as reduction natural killer cytotoxic genes expression, expansion regulatory T cells. But activation naïve cell monocyte subsets, well increased MHC-II-mediated pathway antigen-presenting were still observed...
We developed an image-based electrocardiographic (ECG) quality assessment technique that mimics how clinicians annotate ECG signal quality.We adopted the structural similarity measure (SSIM) to compare images of two records are obtained from displaying ECGs in a standard scale. Then, subset representative training set was selected as templates through clustering method. SSIM between each image and all were used feature vector for linear discriminant analysis classifier. also employed three...
Abstract Background Owing to recent advances in resolution and field-of-view, spatially resolved transcriptomics sequencing, such as Stereo-seq, has emerged a cutting-edge technology for the interpretation of large tissues at single-cell level. To generate accurate spatial gene expression profiles from high-resolution omics data, powerful computational tool is required. Findings We present CellBin, an image-facilitated one-stop pipeline field-of-view transcriptomic data Stereo-seq. CellBin...
We sought to investigate the expression of MALAT1, plasma brain natriuretic peptide, and Tei index in sepsis-induced myocardial injury. The current retrospective analysis focused on 146 sepsis patients admitted our hospital from February 2021 March 2023. Based presence or absence injury, were divided into two groups: group (n = 80) injury 66). 28-day mortality status patients, they also a survival 143 cases death 3 cases. study compared levels between group, as well comparison sets...
The human peripheral blood displays diverse molecular characteristics across populations, understanding the drivers and underlying mechanisms of which remains challenging. Here, we introduce Chinese Immune Multi-Omics Atlas (CIMA), elucidating sex-, age-, genetic-related variations by analyzing multi-omics data from 428 adults with over 10 million immune cells. CIMA generated an enhancer-driven gene regulatory network, identifying 237 high-quality regulons revealing cell type-specific...
BACKGROUND: Sedentary behavior (SB) is associated with chronic musculoskeletal pain, but limited evidence exists about its impact on spinal pain (CSP).AIM: This study aims to explore the relationship between SB, physical activity, and risk of CSP.DESIGN: Cross-sectional cohort design.SETTING: United Kingdom (UK).POPULATION: We included 481872 data collected 2006 2010 for cross-sectional analysis 45,096 longest follow-up up 2019 longitudinal from UK.METHODS: Screen-based SB was defined as...
Abstract We propose a novel flexible jitter-enhanced pulse width modulation(PWM) hardware architecture, which aims to improve the modulation resolution while reducing requirement of PWM frequency. The architecture creatively distributes jitter effect uniformly every radio frequency(RF) cycle corresponding same baseband by controllable jitter, provides new growth method in time domain. flexibility adapt different basebands and frequencies. By using this paper can 5.32 bit at most, EVM...
Abstract The COVID-19 pandemic has accounted for more than five million infections and hundreds of thousand deaths worldwide in the past six months. patients demonstrate a great diversity clinical laboratory manifestations disease severity. Nonetheless, little is known about host genetic contribution to observed inter-individual phenotypic variability. Here, we report first study China by deeply sequencing analyzing 332 categorized varying levels severity from Shenzhen Third People’s...
Patient characteristics associated with false arrhythmia alarms in intensive care Patricia R Harris,1,2 Jessica K Zègre-Hemsey,3,4 Daniel Schindler,5 Yong Bai,6 Michele M Pelter,2,7 Xiao Hu2,8 1Department of Nursing, School Health and Natural Sciences, Dominican University California, San Rafael, 2Department Physiological Francisco, CA, 3School 4Department Emergency Medicine, North Carolina at Chapel Hill, NC, 5Intensive Care Unit, The Neuroscience Center, Sutter Eden Medical Castro Valley,...
It is well recognized that batch effect in single-cell RNA sequencing (scRNA-seq) data remains a big challenge when integrating different datasets. Here, we proposed deepMNN, novel deep learning-based method to correct scRNA-seq data. We first searched mutual nearest neighbor (MNN) pairs across batches principal component analysis (PCA) subspace. Subsequently, correction network was constructed by stacking two residual blocks and further applied for the removal of effects. The loss function...
Sepsis-induced myocardial injury (SIMI) is a severe complication of sepsis, contributing significantly to mortality. Mitochondrial dysfunction and dysregulated autophagy are implicated in SIMI pathogenesis. Long non-coding RNA MALAT1 has been associated with various diseases, including but its role remains unclear.
Body mass index and waist circumference are simple measures of obesity. However, they do not distinguish between visceral subcutaneous fat, or muscle, potentially leading to biased relationships individual body composition parameters adverse health outcomes. The purpose this study was develop validate prediction models for volumetric adipose muscle.Based on cross-sectional data 18,457, 18,260, 17,052 White adults from the UK Biobank, we developed sex-specific equations estimate tissue (VAT),...
Viral infectious diseases are a devastating and continuing threat to human animal health. Receptor binding is the key step for viral entry into host cells. Therefore, recognizing receptors fundamental understanding potential tissue tropism or range of these pathogens. The rapid advancement single-cell RNA sequencing (scRNA-seq) technology has paved way studying expression in different tissues species at resolution, resulting huge scRNA-seq datasets. However, effectively integrating sharing...