A5100413642- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Nanoplatforms for cancer theranostics
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Systemic Lupus Erythematosus Research
- Cytomegalovirus and herpesvirus research
- interferon and immune responses
- Medical Malpractice and Liability Issues
- Frailty in Older Adults
- Occupational Health and Safety Research
- Fungal Plant Pathogen Control
- Body Composition Measurement Techniques
- Garlic and Onion Studies
- Pediatric Hepatobiliary Diseases and Treatments
- COVID-19 and healthcare impacts
- Venous Thromboembolism Diagnosis and Management
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Patient Safety and Medication Errors
- Vibrio bacteria research studies
Cleveland Clinic
2019-2024
Cleveland Eye Clinic
2019-2024
Beijing YouAn Hospital
2011-2023
Capital Medical University
2011-2023
Sun Yat-sen Memorial Hospital
2023
Sun Yat-sen University
2023
Hebei Medical University
2022
First Affiliated Hospital of Hebei Medical University
2022
Fujian Medical University
2017
Union Hospital
2017
We selected 42 early-stage primary biliary cirrhosis (PBC) patients and 30 healthy controls (HC). Metagenomic sequencing of the 16S rRNA gene was used to characterize fecal microbiome. UPLC-MS/MS assaying small molecules metabolomes serum, urine feces. Liquid chip serum cytokines immune profiles. The gut PBC were depleted some potentially beneficial bacteria, such as Acidobacteria, Lachnobacterium sp., Bacteroides eggerthii Ruminococcus bromii, but enriched in bacterial taxa containing...
Plasmodium falciparum infection of human erythrocytes is known to result in the modification host cell cytoskeleton by parasite-coded proteins. However, such modifications and corresponding implications malaria pathogenesis have not been fully explored. Here, we probed gradual infected erythrocyte with advancing stages using atomic force microscopy (AFM). We reported a novel strategy derive accurate quantitative information on knob structures their connections spectrin network performing...
In China, increasing attention has been devoted to the patient safety culture within health administrative departments and healthcare organizations. However, no official version of a assessment tool published or is widely used, little known about status in Chinese hospitals. The aims this study were examine reliability validity Safety Attitudes Questionnaire establish benchmark data on Beijing.Across-sectional survey was conducted from August October 2014 using Chinese. Using stratified...
Abstract Background Hepatitis B virus (HBV)-related liver disease induces damage by hepatic immune and inflammatory response. The association between aberrant peripheral blood mononuclear cell (PBMC) DNA methylation progression of fibrosis remains unclear. Results Here we applied Infinium 450 K BeadChip investigating PBMC genome-wide profiling 48 HBV-related patients including 24 chronic hepatitis (CHB), 14 compensated cirrhosis (LC), 10 decompensated (DLC). In total, there were 7888...
Assessing the length of hospital stay (LOS) in patients with coronavirus disease 2019 (COVID-19) pneumonia is helpful optimizing use efficiency beds and medical resources relieving resource shortages. This retrospective cohort study 97 was conducted at Beijing You’An Hospital between January 21, 2020, March 2020. A multivariate Cox proportional hazards regression based on smallest Akaike information criterion value used to select demographic clinical variables construct a nomogram....
Aberrant methylation and metabolic perturbations may deepen our understanding of hepatocarcinogenesis help identify novel biomarkers for diagnosing hepatocellular carcinoma (HCC). We aimed to develop an HCC model based on a multi-omics.Four hundred patient samples (200 with 200 hepatitis B virus-related liver disease (HBVLD)) were subjected liquid chromatography-mass spectrometry multiplex bisulfite sequencing. Integrative analysis clinical data, CpG metabolome the 20 complete imputation...
Interferon-induced transmembrane protein 3 (IFITM3) is a key signaling molecule regulating cell growth in some tumors, but its function and mechanism hepatocellular carcinoma (HCC) remain unknown. Our study investigated the relationship between expression of IFITM3 HCC development. Material Methods. was identified via multiple gene databases tissue samples. Then, PLC/PRF/5 cells were transfected with lentivirus to knock down overexpress IFITM3. expression, proliferation, migration detected...
Objective To develop a simple, effective, time-saving and low-cost fluorescence protein microarray method for detecting serum alpha-fetoprotein (AFP) in patients with hepatocellular carcinoma (HCC). Method Non-contact piezoelectric print techniques were applied to reduce the cost of prey antibody. Serum samples from HCC healthy control subjects collected evaluated presence AFP using novel microarray. validate microarray, tested an enzyme-linked immunosorbent assay (ELISA). Results A total...
Abstract Interferon-induced transmembrane protein 3 ( IFITM3 ) is a component of ISG (Interferon-Stimulated Gene) family. The association between and hepatocellular carcinoma (HCC) has been reported. While the relationship this genetic variation progress HCC remains unclear. To address issue, we explore IFITM3-rs12252 variants progression in study. A total 336 candidates were enrolled study, including 156 patients with HBV related 180 chronic Hepatitis B infections or liver cirrhosis. Liver...
Laparoscopic hepatectomy is an important treatment method for liver cancer. In the past, resection boundary was usually determined by intraoperative ultrasound, vascular structures, and surgeon experience. With development of anatomical hepatectomy, visual surgery technology has gradually been applied to this type surgery, particularly indocyanine green (ICG)-guided hepatectomy. As ICG can be specifically ingested hepatocytes used fluorescence tracing, negative staining techniques have...
Neuroblast differentiation-associated protein AHNAK, a large structural scaffold protein, remains mysterious in biological processes. AHNAK plays suppressive or progressive role different types of cancers. To investigate the hepatocellular carcinoma (HCC), cell viability assays were performed to determine proliferation stable AHNAK-knockdown HepG2 line; co-immunoprecipitation (Co-IP) and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) on HCC matched paracancerous (MPC)...
The aim of this study was to understand whether enhanced CT can provide more information than unenhanced on diagnosis sarcopenia.We reviewed the data 45 patients pancreatic cancer. Manual tracing psoas muscles used for measuring cross-sectional muscle areas and attenuation at umbilicus level; afterwards, PMI, PMD, Δ PMD were calculated.In scanning, arterial, venous, parenchymal phases CT, PMI values 6.905 ± 2.170, 6.886 2.195, 6.923 2.239, 6.866 2.218, respectively, difference not...
Three new alkamides, achilleamide B-D (1-3) along with five known alkamides (4-8) were isolated from the aerial parts of Achillea alpina L. Structures elucidated by spectroscopic analysis. Modified Mosher's method and electronic circular dichroism (ECD) calculations introduced for absolute configuration 3. The neuroprotective effects all compounds evaluated 6-hydroxydopamine (6-OHDA)-induced cell death in human neuroblastoma SH-SY5Y cells, concentration 50 % maximal effect (EC50 ) values...
Portal vein thrombosis (PVT) is a condition caused by hemodynamic disorders. It may be noted in the portal system when there an inflammatory stimulus abdominal cavity. However, PVT rarely reported after hepatectomy. At present, related guidelines and major expert opinions tend to consider vitamin K antagonists or low-molecular weight heparin (LMWH) as standard treatment. But based on research, direct oral anticoagulants more effective safe for noncirrhotic are also beneficial reducing...
Objective To analyze the differentiation status of CTL and to evaluate its clinical value in patients with HIV/HCV coinfection. Methods Twenty-eight coinfection twelve single HCV infection were enrolled this study. The technique Fibro-Scan was used liver fibrosis. viral load detected by real-time quantitative PCR. Flow cytometry analysis performed measure CTL. Results Both levels alanine transaminase (ALT) alkaline phosphatase (ALP) significantly higher than those...
Laparoscopic hepatectomy is an important treatment method for liver cancer. In the past, resection boundary was usually determined by intraoperative ultrasound, vascular structures, and surgeon experience. With development of anatomical hepatectomy, visual surgery technology has gradually been applied to this type surgery, particularly indocyanine green (ICG)-guided hepatectomy. As ICG can be specifically ingested hepatocytes used fluorescence tracing, negative staining techniques have...