A5100648877- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Cancer Genomics and Diagnostics
- Mitochondrial Function and Pathology
- Thyroid Cancer Diagnosis and Treatment
- interferon and immune responses
- Nitric Oxide and Endothelin Effects
- Monoclonal and Polyclonal Antibodies Research
- Inflammasome and immune disorders
- Vitamin D Research Studies
- Colorectal Cancer Treatments and Studies
- S100 Proteins and Annexins
- Bone Metabolism and Diseases
- Multiple Myeloma Research and Treatments
- Liver Disease Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Hepatitis C virus research
- Circular RNAs in diseases
- Laser Applications in Dentistry and Medicine
- Neuroendocrine Tumor Research Advances
- Blood groups and transfusion
- Viral Infections and Vectors
Second Affiliated Hospital of Jilin University
2023
Jilin University
2023
Tianjin First Center Hospital
2023
Tianjin Medical University
2023
Nankai University
2023
Jinan Central Hospital
2023
Shandong First Medical University
2023
China Medical University
2020-2021
BeiGene (China)
2018
Massachusetts General Hospital
2013
Antibodies targeting PD-1 have been demonstrated durable anti-cancer activity in certain cancer types. However, the anti-PD-1 antibodies are less or not efficacious many situations, which might be attributed to co-expression of multiple inhibitory receptors presence immunosuppressive cells tumor microenvironment. Most used clinical studies IgG4 isotype with S228P mutation (IgG4S228P). The functional impact by interaction IgG4S228P antibody Fc gamma (FcγRs) is poorly understood. To assess...
Intrinsic vitamin D affects the proliferation, apoptosis, invasion, metastasis, and tumorigenesis of lung cancer by regulating tumor signaling pathways. Histidine-rich calcium-binding protein (HRC) maintains Ca2+ homeostasis, which plays crucial roles in occurrence development cancer. Our study aims to investigate ability regulation HRC role playing We investigated effects on underlying mechanisms, measuring receptor (VDR) expression cancer, paracancer, normal tissues from patients using...
Aim: This study sets out to investigate the possible effects of miRNA-148a-3p (miR-148a-3p) on osteoblast differentiation and bone remodeling following osteoporosis. Materials & methods: Expression miR-148a-3p, p300, Nrf2 differentiation-related proteins (Runx2, Osteocalcin Col1a1) was examined in MC3T3-E1 cell line, followed by identification interaction between miR-148a-3p p300 Nrf2. After ectopic expression depletion experiments cells, proliferation, osteogenic mineralization were...
Chromosomal instability (CIN) is closely associated to the early detection of several clinical tumours. In this study, authors first established a novel prognostic model melanoma using hub genes CIN, based on datasets The cancer genome atlas-skin cutaneous (TCGA-SKCM) and GSE65904 cohorts. Based risk scores our model, disease-specific survival (DSS) prognosis was worse in high-risk group. Combining score, stage, age, ulceration, clark factors, Nomogram generated predict 1, 3, 5-year rates,...
Objective To analyze the differentiation status of CTL and to evaluate its clinical value in patients with HIV/HCV coinfection. Methods Twenty-eight coinfection twelve single HCV infection were enrolled this study. The technique Fibro-Scan was used liver fibrosis. viral load detected by real-time quantitative PCR. Flow cytometry analysis performed measure CTL. Results Both levels alanine transaminase (ALT) alkaline phosphatase (ALP) significantly higher than those...
Background: LLLT has been shown to be neurorprotective against cerebral ischemia in animals. Initial human clinical trials demonstrated safety and potential beneficial profiles. A pivotal trial with TLT is ongoing for ischemic stroke. However, the underlying neuroprotective mechanisms require further definition. We previously showed protected primary neurons OGD. In current study, we tested hypothesis that may attenuate OGD-induced nitric oxide (NO) ROS production associated cell survival...