A5100456973- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Metabolomics and Mass Spectrometry Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Studies
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Circular RNAs in diseases
- Endometrial and Cervical Cancer Treatments
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Radiomics and Machine Learning in Medical Imaging
- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Cancer Genomics and Diagnostics
- Immune cells in cancer
Hunan Cancer Hospital
2020-2025
Central South University
2015-2025
Northwest University
2022-2024
State Administration of Cultural Heritage
2022-2024
Harbin Medical University
2015-2024
Qingdao University
2024
Kyungpook National University
2022-2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Anhui University
2024
Antibodies targeting PD-1 have been demonstrated durable anti-cancer activity in certain cancer types. However, the anti-PD-1 antibodies are less or not efficacious many situations, which might be attributed to co-expression of multiple inhibitory receptors presence immunosuppressive cells tumor microenvironment. Most used clinical studies IgG4 isotype with S228P mutation (IgG4S228P). The functional impact by interaction IgG4S228P antibody Fc gamma (FcγRs) is poorly understood. To assess...
Abstract To investigate the potential mechanisms underlying neutrophil extracellular traps (NETs) confer ferroptosis resistance and CD8(+) T cell inhibition in lung adenocarcinoma (LUAD). By intravenous injection of LLC cells into tail vein, a LUAD mouse model was created. Phorbol‐12‐myristate‐13‐acetate (PMA) stimulated neutrophils to facilitate NETs formation combined with inhibitor DNase I explore mechanism on proliferation, migration, resistance, activity. CitH3, myeloperoxidase (MPO),...
Background: Obesity is closely associated with chronic diseases such as hypertension, type 2 diabetes mellitus (T2DM), and dyslipidemia. We analyzed the optimal obesity index cut-off values for metabolic syndrome (MetS), identified that more these diseases, in a population of northern Chinese.Methods: surveyed 8940 adults (age, 20–74 years) living China diseases. Receiver operating characteristics (ROC) analysis, relative risk, multivariate regression were used to develop an appropriate MetS...
To evaluate the application of urinary metabolomics on discovering potential biomarkers for epithelial ovarian cancer (EOC), urine samples from 40 preoperative EOC patients, 62 benign tumor (BOT) and 54 healthy controls were collected analyzed with ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS). Good separations obtained vs BOT, by partial least-squares discriminant analysis, or principal component analysis. Twenty-two ascertained...
For the past 20 years, GPCRDB (G protein-coupled receptors database; http://www.gpcr.org/7tm/) has been a 'one-stop shop' for G receptor (GPCR)-related data. The contains experimental data on sequences, ligand-binding constants, mutations and oligomers, as well many different types of computationally derived data, such multiple sequence alignments homology models. also provides visualization analysis tools, plus number query systems. In latest release, all alignments, >65 000 models, have...
The complexity of metabolome presents a great analytical challenge for quantitative metabolite profiling, and restricts the application metabolomics in biomarker discovery. Targeted using multiple-reaction monitoring (MRM) technique has excellent capability analysis, but suffers from limited coverage. To address this challenge, we developed new strategy, namely, SWATHtoMRM, which utilizes broad coverage SWATH-MS technology to develop high-coverage targeted method. Specifically, was first...
Ovarian cancer is the leading cause of death in gynecologic malignancies. Profiling endogenous metabolites has potential to identify changes caused by and provide inspiring insights into metabolism. To systematically investigate ovarian metabolism, we performed metabolic profiling 448 plasma samples related epithelial (EOC) based on ultra-performance liquid chromatography mass spectrometry both positive negative modes. These unbiased metabolomic profiles could well distinguish EOC from...
Abstract A new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer hydrogels was prepared. The inner core sodium alginate (SA) carboxymethyl cellulose (CMC), formed by physical crosslinking pH-sensitive property. polymer out-layer enhanced stability introduced chemical to eliminate the expansion diffusion content. physicochemical structure double-layer characterized....
The aims of the present study were to examine serum amino acid profiles in obese and non-obese women investigate relationships between acids inflammation oxidative stress a human case–control study. Serum acids, inflammatory biomarkers (C-reactive protein IL-6) (superoxide dismutase, malondialdehyde glutathione peroxidase) measured compared 235 217 controls. examined using multiple linear regression. Among determined, histidine, arginine, threonine, glycine, lysine serine found be...
Previous studies have demonstrated that chronic brain hypoperfusion (CBH) causes Aβ aggregation by upregulating expression of amyloid precursor protein (APP) and β-site APP cleaving enzyme 1 (BACE1) protein, which is accompanied cognitive impairment, but the mechanisms are not fully understood. In this study, we evaluated effect microRNA on memory impairment in rats induced CBH. We show here CBH generated bilateral common carotid artery occlusion (2VO) significantly decreased learning...
Abstract Cervical cancer (CC) still remains a common and deadly malignancy among females in developing countries. More accurate reliable diagnostic methods/biomarkers should be discovered. In this study, we performed comprehensive analysis of metabolomics (285 samples) transcriptomics (52 on the potential implication metabolic characteristic description cervical cancer. Sixty-two metabolites were different between CC normal controls (NOR), which 5 (bilirubin, LysoPC(17:0), n-oleoyl...
Background: To develop and validate a nomogram based on the conventional measurements log of odds between number positive lymph node negative (LODDS) in predicting prognosis for cervical cancer patients after surgery.Methods: A total 8202 with pathologically confirmed 2004 2014 were obtained from Surveillance, Epidemiology, End Results (SEER) database.All divided into training (n=3603) validation (n=4599) cohorts consecutive age diagnosis.Demographic clinical pathological factors evaluated...
Colorectal cancer (CRC) is one of the most common malignancies worldwide. The prognosis for this poor, and development novel biomarkers, particularly non-invasive surrogate urgently needed. Recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in blood can serve as useful biomarkers various types cancer. In study, miR-183 expression levels were found to be significantly overexpressed plasma samples from CRC patients compared with controls, postoperative reduced...
The idea that changes to the host immune system are critical for cancer progression was proposed a century ago and recently regained experimental support. Herein, hypothesis hepatocellular carcinoma (HCC) leaves molecular signature in peripheral tested by profiling DNA methylation blood mononuclear cells (PBMC) T from discovery cohort (n = 69) of healthy controls, chronic hepatitis, HCC using Illumina 450K platform validated two validation sets 80 n 48) pyrosequencing. study reveals broad...
Programmed cell death protein 1 (PD-1), an immune checkpoint receptor expressed by activated T, B, and NK cells, is a well-known target for cancer immunotherapy. Tislelizumab (BGB-A317) anti-PD-1 antibody that has recently been approved treatment of Hodgkin's lymphoma urothelial carcinoma. Here, we show tislelizumab displayed remarkable antitumor efficacy in B16F10/GM-CSF mouse model. Structural biology Surface plasmon resonance (SPR) analyses revealed unique epitopes tislelizumab,...