A5033148406- Nerve injury and regeneration
- RNA Interference and Gene Delivery
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Nerve Injury and Rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Hip and Femur Fractures
- Pharmacological Effects of Natural Compounds
- Wound Healing and Treatments
- Lymphoma Diagnosis and Treatment
- Veterinary Orthopedics and Neurology
- Antimicrobial Peptides and Activities
- Cancer Genomics and Diagnostics
- Skin and Cellular Biology Research
- Cardiac Arrest and Resuscitation
Guangdong Medical College
2013-2025
Dongguan People’s Hospital
2023-2024
Sun Yat-sen University
2010-2023
Sun Yat-sen Memorial Hospital
2023
BeiGene (China)
2019-2021
Texas A&M University
2020
IHI Corporation (United States)
2019
The First Affiliated Hospital, Sun Yat-sen University
2012-2013
Programmed cell death protein 1 (PD-1), an immune checkpoint receptor expressed by activated T, B, and NK cells, is a well-known target for cancer immunotherapy. Tislelizumab (BGB-A317) anti-PD-1 antibody that has recently been approved treatment of Hodgkin's lymphoma urothelial carcinoma. Here, we show tislelizumab displayed remarkable antitumor efficacy in B16F10/GM-CSF mouse model. Structural biology Surface plasmon resonance (SPR) analyses revealed unique epitopes tislelizumab,...
Hydrogen sulfide (H2S) takes part in a diverse range of intracellular pathways and hss physical pathological properties vitro vivo. However, the effects H2S on cancer are controversial remain unclear. The present study investigates liver progression via activating NF-κB pathway PLC/PRF/5 hepatoma cells. cells were pretreated with 500 µmol/l NaHS (a donor H2S) for 24 h. expression levels CSE, CBS, phosphosphorylate (p)-NF-κB p65, caspase-3, COX-2, p-IκB MMP-2 measured by western blot assay....
Our previous RNA sequencing study showed that the long non-coding ischemia-related factor Vof-16 (lncRNA Vof-16) was upregulated after spinal cord injury, but its precise role in injury remains unclear. Bioinformatics predictions have indicated lncRNA may participate pathophysiological processes of inflammation and apoptosis. PC12 cells were transfected with a pHBLV-U6-MCS-CMV-ZsGreen-PGK-PURO vector to express an knockdown lentivirus pHLV-CMVIE-ZsGree-Puro overexpression lentivirus. The...
Neuron death is caused primarily by apoptosis after spinal cord injury (SCI). Autophagy, as a cellular response, can maintain homeostasis to reduce apoptosis. We aimed investigate the effect and mechanism of vimentin knockdown on autophagy neural recovery SCI.
Long non-coding RNAs (lncRNAs) are abundantly expressed in the central nervous system and exert a critical role gene regulation via multiple biological processes. To uncover functional significance molecular mechanisms of lncRNAs spinal cord injury (SCI), expression signatures were profiled using RNA sequencing (RNA-seq) technology Sprague-Dawley rat model 10th thoracic vertebra complete transection SCI. Results showed that 116 14,802 detected differentially expressed, among which...
To improve the survival and/or differentiation of grafted BMSCs (bone marrow stem cells) represents one challenges for promising cell-based therapy. Considerable reports have implicated Sal B (salvianolic acid B), a potent aqueous extract Salvia miltiorrhiza, in enhancing cells under various conditions. In this study, we investigated effect on H₂O₂-induced apoptosis rat BMSCs, focusing signalling pathways. Results indicated that MEK [MAPK (mitogen-activated protein kinase)/ERK...
Spinal root avulsion typically leads to massive motoneuron death and severe functional deficits of the target muscles. Multiple pathological factors such as neuron loss, induction inhibitory molecules, insufficient regeneration are responsible for poor recovery. Leucine-rich repeat immunoglobulin-like domain-containing Nogo receptor-interacting protein 1 (LINGO-1), a central nervous system (CNS)-specific transmembrane that is selectively expressed on neurons oligodendrocytes, serves potent...
Salvianolic acid B, an active pharmaceutical compound present in Salvia miltiorrhiza, exerts a neuroprotective effect animal models of brain and spinal cord injury. B can promote recovery neurological function; however, its protective on the myelin sheath after injury remains poorly understood. Thus, this study, vitro tests showed that salvianolic contributed to oligodendrocyte precursor cell differentiation, most effective dose was 20 μg/mL. For vivo investigation, rats with were...
Abstract Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor expressed by activated T, B, and NK cells, which interacts with its ligand PD-L1/L2 to inhibit T-cell proliferation effector functions such as tumor killing cytokine production. Two anti-PD-1 antibodies approved the FDA, pembrolizumab nivolumab, have shown efficacy in many cancer types, nevertheless there are some indications where limited observed. Tislelizumab (BGB-A317), investigational antibody, has...
Brachial plexus avulsion often results in massive motor neuron death and severe functional deficits of target muscles. However, no satisfactory treatment is currently available. Hypoxia-inducible factor 1α a critical molecule targeting several genes associated with ischemia-hypoxia damage angiogenesis. In this study, rat model brachial avulsion-reimplantation was established, which C5–7 ventral nerve roots were avulsed only the C6 root reimplanted. Different implants immediately injected...
Hepatocellular carcinomas (HCC) are adapted to survive extreme genomic stress conditions imposed by hyperactive DNA replication and genotoxic drug treatment. The underlying mechanisms remain unclear, but may involve intensified damage response/repair programs. Here, we investigate a new role of nucleostemin (NS) in allowing HCC its own malignancy, as NS was previously shown promote liver regeneration via repair mechanism. We first established that higher transcript level correlates with...
In Brief Study Design. We used a complete spinal cord transection model and locomotor function, histological, immunohistochemical examinations to evaluate the effects of local injection lentivirus/LINGO-1-short hairpin RNA (VL) on rats with injury (SCI). Objective. To demonstrate neuroregenerative neuroprotective LINGO-1 RNAi SCI rats. Summary Background Data. has been reported as negative regulator axonal sprouting its antagonist was determined improve functional outcomes in However, it not...
Brachial plexus avulsion (BPA) is a devastating traumatic peripheral nerve injury complicated with paralysis of the upper extremity. We previously reported that leucine-rich repeat and immunoglobulin-like domain-containing NOGO receptor-interacting protein 1 (LINGO-1) has potent role in inhibiting neuron survival axonal regeneration after central nervous system (CNS) damage miR-615 potential microRNA (miRNA) negatively regulated LINGO-1. However, effect BPA remains to be elucidated....