A5074481742- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Ovarian cancer diagnosis and treatment
- Cancer Mechanisms and Therapy
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- RNA modifications and cancer
- Mechanisms of cancer metastasis
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Estrogen and related hormone effects
- Intraperitoneal and Appendiceal Malignancies
- Lung Cancer Research Studies
- Colorectal and Anal Carcinomas
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Endometriosis Research and Treatment
Harbin Medical University
2010-2025
Third Affiliated Hospital of Harbin Medical University
2011-2025
Hulunbuir University
2011
Red Cross Hospital
2011
Fifth Hospital In Wuhan
2011
Wuhan University
2011
The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
2006
We reported that long non-coding RNA ZFAS1 was upregulated in epithelial ovarian cancer tissues, and negatively correlated to the overall survival rate of patients with this study. While depletion inhibited proliferation, migration, development chemoresistance, overexpression exhibited an even higher proliferation rate, migration activity, chemoresistance cell lines. further found miR-150-5p a potential target ZFAS1, which downregulated tissue. MiR-150-5p subsequently expression...
In a seminal study published in Nature, Hwang et al. recently revealed for the first time that Transgelin 2 (TAGLN2) regulates lipid metabolism and antitumor function through interaction with fatty acid binding protein 5 (FABP5) CD8+ T cells [1]. The mechanism by which TAGLN2 is inhibited endoplasmic reticulum (ER) stress microenvironment of ovarian cancer (OC) leading to T-cell dysfunction was clarified, providing new target potential strategy improving immunotherapy solid tumors. Lipid...
The microRNA miR-133a is dysregulated in many types of cancer, but the underlying mechanism remains largely unknown. In this study, we showed that expression level was reduced ovarian cancer tissues compared with normal ovaries. Ectopic significantly inhibited cell proliferation and colony formation, induced G1-phase cycle arrest, whereas decreased dramatically enhanced formation. Importantly, overexpression suppressed vivo tumor growth nude mice models. Through silico search, found...
Wnt7a is a secreted glycoprotein that regulates normal cellular proliferation and differentiation, as well tumorigenesis progression. The aim of the present study was to detect level expression in endometrial cancer explore its role progression prognosis cancer.Immunohistochemistry used examine 244 specimens, 48 benign lesion 43 endometrium specimens. χ(2) Analysis, Kaplan-Meier analysis log-rank test, multivariate Cox proportional hazards were applied for statistical analysis.Wnt7a...
This phase 2 study assesses the efficacy and safety of camrelizumab (an anti-PD-1 antibody) plus famitinib (anti-angiogenic agent) in women with pretreated recurrent or metastatic cervical cancer (ClinicalTrials.gov NCT03827837). Patients histologically cytologically confirmed squamous cell carcinoma experiencing relapse progression during after 1-2 lines systemic therapy for disease are enrolled. Eligible patients receive 200 mg intravenously on day 1 each 3-week cycle 20 orally once daily....
Early diagnosis of intraperitoneal metastasis is a pivot for survival patients with serous epithelial ovarian cancers (SEOC). However, to date, there lack efficient molecular biomarker early SEOC. Here, we found that the expression chloride intracellular channel 1 (CLIC1) highly correlative metastasis. There very low CLIC1 in normal ovaries (NO), benign tumor (BOT), and primary cancer without (POCNM); but its remarkably high (POCM) omentum peritoneal Furthermore, clinic prediction SEOC,...
Lysosome-associated protein transmembrane 4 beta (LAPTM4B) is an important novel gene associated with the proliferation and differentiation of cells. Recent studies have shown that it was overexpressed in many cancer tissues. This study investigated association between different LAPTM4B polymorphisms susceptibility prognosis ovarian cancer. A case–control performed 282 patients 365 control subjects. Genomic DNA extracted from peripheral blood lymphocytes all participants. genotypes were...
Background: Lysosomal protein transmembrane 4 β-35 (LAPTM4B-35), a novel oncoprotein that belongs to the mammalian 4-tetratransmembrane spanning superfamily, has been implicated in oncogenesis and cancer progression several solid malignances. However, expression of LAPTM4B-35 its role endometrial remain unknown. Materials Methods: We investigated by immunohistochemistry 30 normal endometrium specimens 165 carcinomas analyzed correlation with various clinicopathologic features, including...
Astrocyte elevated gene-1 (AEG-1) plays an important role in tumor progression including transformation, evasion of apoptosis, invasion, metastasis, and chemoresistance. However, the expression AEG-1 ovarian carcinoma its significance are still unclear. The aim this study was to examine carcinoma. Immunohistochemistry performed determine 81 specimens. correlation with clinicopathological parameters assessed using χ2 analysis. Patient survival analyzed Kaplan-Meier log-rank tests. Cox...
Lysosomal associated protein transmembrane 4 B (LAPTM4B) is a recently discovered gene with the characteristics of oncogenes. This article presents preliminary review structure, biological function and genetic polymorphisms LAPTM4B its role in cancer prognosis. Key words: Lysosome-associated beta; Neoplasms; Oncogene; Prognosis
Background: Minichromosome maintenance (MCM) proteins are a family of replication licensing factors, and accumulating evidence indicates that the aberrant expression MCMs is common phenomenon in malignancies. However, patterns exact roles by which each MCM contributes to tumorigenesis progression soft tissue sarcoma (STS) have not yet been elucidated.Methods: The expression, prognostic value, genetic mutations, functions, immune infiltration were investigated using several databases...
Abstract Background: N6-methyladenosine(m6A) is one of the most common RNA modifications that occurs at nitrogen-6 position adenine. Emerging evidence has revealed regulatory functions m6A play an essential role in development cancer. However study ovarian cancer(OC) still our infancy. In this work ,we aimed to identify and analysis differentially expressed genes(DEGs） modified by which can provide new therapeutic targets key biomarkers OC.Methods: We downloaded Microarray datasets GSE146553...