A5024531115- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Health and Risk Factors
- Birth, Development, and Health
- Frailty in Older Adults
- COVID-19 Clinical Research Studies
- Nutrition and Health in Aging
- Hemodynamic Monitoring and Therapy
- Genomics and Chromatin Dynamics
- Cancer Mechanisms and Therapy
- interferon and immune responses
- Metabolomics and Mass Spectrometry Studies
- Atherosclerosis and Cardiovascular Diseases
- Ubiquitin and proteasome pathways
- Cardiac Imaging and Diagnostics
- Respiratory Support and Mechanisms
- Traditional Chinese Medicine Studies
- Phytoestrogen effects and research
Shandong University of Traditional Chinese Medicine
2020-2025
First Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Shanghai University
2024-2025
Huazhong University of Science and Technology
2018-2024
Tongji Hospital
2018-2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2021-2024
Fifth Hospital In Wuhan
2010-2022
Zhejiang Chinese Medical University
2022
Wuhan University
2010-2022
Abstract Aims Assessing the global burden and health inequalities of Hypertension Heart Disease (HHD) during period from 1990 to 2019. Methods Secondary analysis Global Burden (GBD) study in 2019, focusing on diseases, injuries, risk factors worldwide. Disability-Adjusted Life Years (DALYs) data related HHD are extracted 2019 GBD. Inequality Slope Index (SII) Concentration calculated assess across regions countries. Results The total DALYs for reached 21.51 million, demonstrating a...
Background/Aim Depression has become a multiple disease worldwide, and is closely related to the systemic inflammatory response. Methods Based on data of National Health Nutrition Examination Survey (NHANES), this study included 2,514 depressive 26,487 non-depressive adults. The immune-inflammation index (SII) inflammation response (SIRI) were used quantify inflammation. multivariate logistic regression inverse probability weighting methods analyze effect size SII SIRI risk depression....
Recent insights suggest that remnant cholesterol (RC) plays a role in cellular senescence, yet its specific contribution to frailty remains indeterminate. Through the integration of observational and mendelian randomization (MR) studies, this research explores impact elevated serum RC levels on susceptibility.A dual-method approach, combining an study with MR study, was employed investigate connection between frailty. The included 11,838 participants from National Health Nutrition...
This study focused on circulating plasma protein profiles to identify mediators of hypertension-driven myocardial remodeling and heart failure.
Background Estimated pulse wave velocity (ePWV) has been found to be an independent predictor of cardiovascular mortality and kidney injury, which can estimated noninvasively. This study aimed investigate the association between ePWV in-hospital in critically ill patients with acute injury (AKI).
Acute lung injury (ALI) has high morbidity and mortality. Lifei Qingchang Tang (LFQCT), a traditional Chinese medicine, antioxidant anti-inflammatory properties but its mechanism in ALI remains unclear. In vitro, LFQCT reduced intracellular Ca2+, ROS, NO LPS-induced RAW 264.7 cells, suppressed pro-inflammatory mediators (TNF-α, IL-1β, IL-6), iNOS, COX-2, blocked phosphorylation of IKK-α/β, p65, ERK1/2, JNK1/2, p38. It also inhibited p65 activation nuclear translocation. vivo, attenuated mice...
Abstract Codonopsis radix, Astragalus membranaceus, Platycodon grandiflorus, and Tiger milk mushroom are promising candidates for functional food development. However, their limited bioavailability impedes a challenge to broader applications. In this study, fermentation of these medicine homologous (MFHs) materials using Lactobacillus plantarum was optimized enhance antioxidant activity. Through single-factor experiments Pareto analysis, the key factors influencing DPPH radical scavenging...
Abstract Background It is unknown whether D2 lymphadenectomy + complete mesogastric excision for gastric cancer improves survival compared with just lymphadenectomy. Methods Between September 2014 and June 2018, patients advanced were randomly assigned (1 : 1) to laparoscopic or gastrectomy. The modified intention-to-treat population was defined as who had pathologically confirmed adenocarcinoma (pT1 N1–3 M0 pT2–4 N0–3 M0). primary endpoint 3-year disease-free survival. Secondary endpoints...
A knowledge graph can effectively showcase the essential characteristics of data and is increasingly emerging as a significant means integrating information in field artificial intelligence. Coronary artery plaque represents etiology cardiovascular events, posing diagnostic challenge for clinicians who are confronted with multitude nonspecific symptoms. To visualize hierarchical relationship network molecular mechanisms underlying properties symptom phenotypes, patient symptomatology was...
Optimized dietary patterns have been considered an important determinant of delaying aging in cardiometabolic disease (CMD). Dietary pattern with high-level inflammatory potential is a key risk factor for disease, and has drawn increasing attention. The aim this study was to investigate whether high associated acceleration disease.We analyzed the cross-sectional data from six survey cycles (1999-2000, 2001-2002, 2003-2004, 2005-2006, 2007-2008, 2009-2010) National Health Nutritional...
Carotid-femoral pulse wave velocity has been identified as an autonomous predictor of cardiovascular mortality and kidney injury. This important clinical parameter can be non-invasively estimated using the calculated (ePWV). The objective this study was to examine correlation between ePWV in-hospital well one-year among critically ill patients with chronic disease (CKD) atherosclerotic heart (ASHD).
Lysosome-associated protein transmembrane 4β-35 (LAPTM4B-35) is a member of the mammalian 4-tetratransmembrane spanning superfamily, which overexpressed in several solid malignancies. However, expression LAPTM4B-35 and its role progression cervical carcinoma unknown. The aim this study was to determine level carcinoma. Immunohistochemistry used 53 intraepithelial neoplasias (CINs) 113 carcinomas comparison with 20 normal specimens. correlation between clinicopathologic characteristics...
Astrocyte elevated gene-1 (AEG-1) plays an important role in tumor progression including transformation, evasion of apoptosis, invasion, metastasis, and chemoresistance. However, the expression AEG-1 ovarian carcinoma its significance are still unclear. The aim this study was to examine carcinoma. Immunohistochemistry performed determine 81 specimens. correlation with clinicopathological parameters assessed using χ2 analysis. Patient survival analyzed Kaplan-Meier log-rank tests. Cox...
Implementation of complete mesogastric excision in gastric cancer surgery, named D2 lymphadenectomy plus (D2+CME), has recently been proposed as an optimal procedure. However, the safety and efficacy D2+CME remain uncertain. In this randomized controlled trial, patients receiving exhibit less intraoperative blood loss, more lymph node harvesting, earlier postoperative flatus than conventional radical surgery. Univariate Cox regression analysis reveals that risk ratio for group is 1.247 (p =...
Acute pulmonary embolism (APE) is a typical cardiovascular emergency worldwide. Mean hemoglobin concentration (MCHC) standard indicator of anemia. Studies on the association between MCHC and APE are scarce. We aimed to investigate relationship APE.Clinical data were extracted from Medical Information Bank for Intensive Care (MIMIC)-III. Adult (≥18 years) patients with admitted first time included in this study. An analysis was conducted evaluate prognosis by Cox regression analysis,...
Background/Aim: Several observational studies showed a significant association between elevated iron status biomarkers levels and sepsis with the unclear direction of causality. A two-sample bidirectional mendelian randomization (MR) study was designed to identify causal seven traits sepsis. Methods: Seven were studied, including serum iron, ferritin, transferrin saturation, transferrin, hemoglobin, erythrocyte count, reticulocyte count. MR analysis first performed estimate effect on risk...
Introduction: Tuberculosis (TB) is an infectious disease caused by a bacterium called Mycobacterium tuberculosis ( Mtb ). Previous studies have primarily focused on the transmissibility of multidrug-resistant (MDR) or extensively drug-resistant (XDR) . However, variations in virulence across lineages may also account for differences transmissibility. In , polyketide synthase (PKS) genes encode large multifunctional proteins which been shown to be major mycobacterial factors. Therefore, this...
A novel gene called LAPTM4B (lysosome-associated protein transmembrane 4 beta) plays several crucial roles in carcinogenesis. In this case-control study, we investigated the relationship between polymorphism and susceptibility to endometrial carcinoma (EC). an adjusted multivariate logistic regression analyses, subjects with LAPTM4B*1/2 *2/2 genotypes respectively exhibited 1.572-fold (95% confidence interval (CI) = 1.041–2.375) 2.335-fold CI 1.365–3.995) increases risk of developing EC...