A5100323168- Barrier Structure and Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Brain Tumor Detection and Classification
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Transcranial Magnetic Stimulation Studies
- Gut microbiota and health
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- AI in cancer detection
- Extracellular vesicles in disease
- Neuroscience and Neuropharmacology Research
- Radiomics and Machine Learning in Medical Imaging
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Traditional Chinese Medicine Analysis
- Nerve injury and regeneration
- Colorectal Cancer Treatments and Studies
- Neurological Disorders and Treatments
- Photoreceptor and optogenetics research
- Vagus Nerve Stimulation Research
- Nanoplatforms for cancer theranostics
- Cannabis and Cannabinoid Research
XinHua Hospital
2025
Shanghai Jiao Tong University
2025
Shandong University of Traditional Chinese Medicine
2025
Yangtze University
2024
Sun Yat-sen University
2018-2023
Qingdao Agricultural University
2023
Jilin University
2017-2023
Third Affiliated Hospital of Sun Yat-sen University
2020-2023
First Hospital of Jilin University
2017-2023
Southwest Medical University
2023
Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic stroke. However, the current clinical treatments are remained on single pathological process, which due to lack of comprehensive neuroprotective effects. Herein, macrophage-disguised honeycomb manganese dioxide (MnO2 ) nanosphere loaded with fingolimod (FTY) developed salvage penumbra. In particular, biomimetic nanoparticles can accumulate actively damaged brain via macrophage-membrane protein-mediated...
Obesity-induced colonic inflammation-stimulated colitis is one of the main causes colorectal cancer. Dietary polysaccharides are considered an effective agent for relieving obesity-induced inflammatory diseases such as diabetes and colitis. In this work, protective effects a polysaccharide (RTFP) extracted from Rosa roxburghii Tratt fruit on barrier dysfunction inflammation were investigated using model mice. RTFP treatment repaired intestinal by increasing expression tight junction proteins...
Convolutional neural networks (CNNs) have demonstrated excellent performance for brain disease classification from MRI data. However, CNNs lack the ability to capture global dependencies. The recently proposed architecture called Transformer uses attention mechanisms match or even outperform on various vision tasks. Transformer's is dependent access large training datasets, but sample sizes most datasets are relatively small. To overcome this limitation, we propose Trans-ResNet, a novel...
The cannabinoid receptor 2 (CB2R) has been considered as a potential therapeutic target to ameliorate the neuroinflammation and cognitive impairments of Alzheimer's disease (AD). However, there little research on diverse roles CB2R in regulating different forms abilities underlying neuroinflammatory mechanisms. Thus, focus present study was investigate effects activation abilities, phenotype conversion microglia, dendrite complexity. Results showed that normalized cortex-dependent novel...
131I therapy is clinically unfeasible for anaplastic thyroid carcinoma (ATC), due to lack of active targets and ATC's resistance radiation. Novel radionuclide-labeled targeted nano-drug delivery systems have exhibited the potential prominent tumor imaging remedy. Capitalizing on recent research achievements in nanotechnology nuclear medicine, we sought develop a radiolabeled nano-drug, which could specifically accumulate ATCs via tumor-selective system treat tumors with both radionuclide...
This study aims to explore the effects of TLR4 signaling pathway on apoptosis neuronal cells in rats with diabetes mellitus complicated cerebral infarction (DMCI). A DMCI model was established 40 Sprague Dawley rats, which were assigned into blank, sham, DM + middle artery occlusion (MCAO) and MCAO TAK242 groups. Superoxide dismutase (SOD) activity malondialdehyde (MDA) content measured. TUNEL assay applied for detecting cell apoptosis, Western blotting used expression TLR4, TNF-α, IL-1β...
Abstract Environmental exposure to lead (Pb) can damage the central nervous system (CNS) in humans. High‐fat diet (HFD) also has been suggested impair neurocognitive function. Blood–brain barrier (BBB) is a rigorous permeability for maintaining homeostasis of CNS. The BBB caused by tight junctions (TJs) disruption etiology various CNS disorders. This study aimed investigate whether HFD could exacerbate Pb induced destruction integrity TJs disruption. To this end, we measured cell viability...
Abstract Objective The aim of this study is to investigate the role molecular mechanism microRNA (miR)‐21 on tight junction (TJ)‐proteins and its protective effects intestinal barrier. Methods TJ proteins target genes expression were analyzed in miR‐21 inhibition overexpression NCM460 cell lines. To further verify miR‐21, mmu‐miR‐21 epithelial conditional knockout (IKO) mice model was established. MiR‐21 detected clinical specimens acute stercoral obstruction patients. Results Rho‐associated...
Background: Chronic cerebral hypoperfusion (CCH) is commonly accompanied by brain injury and glial activation. In addition to white matter lesions, the intensity of CCH greatly affects degree gray damage. However, little understood about underlying molecular mechanisms related cortical lesions activation following hypoperfusion. Efforts investigate relationship between neuropathological alternations gene expression changes support a role for identifying novel pathways transcriptomic...
Objectives The diagnosis and treatment of brain tumors have greatly benefited from extensive research in traditional radiomics, leading to improved efficiency for clinicians. With the rapid development cutting-edge technologies, especially deep learning, further improvements accuracy automation are expected. In this study, we explored a hybrid learning scheme that integrates several advanced techniques achieve reliable primary with enhanced classification performance interpretability....
Abstract Metabolic genes have played a significant role in tumor development and prognosis. In this study, we constructed metabolic risk model to predict the prognosis of colon cancer based on The Cancer Genome Atlas (TCGA) validated by Gene Expression Omnibus (GEO). We extracted 753 identified 139 differentially expressed (DEGs) from TCGA database. Then conducted univariate cox regression analysis Least Absolute Shrinkage Selection Operator Cox identify prognosis-related construct model. An...
Abstract The objective was to synthesize results from studies that assessed symptom relief after repetitive transcranial magnetic stimulation (rTMS) treatment for post‐traumatic stress disorder (PTSD) and investigate the long‐term effectiveness of rTMS treating PTSD. We searched multiple databases relevant randomized controlled trials PTSD up 1 January 2023. Two researchers evaluated focused on CAPS PCL as outcome indicators. used STATA17 SE software data analysis. Eight articles involving...
The aim of this study was to test the hypothesis that exercise training promotes motor recovery after stroke by facilitating axonal remodeling via inhibition Nogo-A/NgR1 and Rho-A pathway.A distal middle cerebral artery occlusion model generated in stroke-prone renovascular hypertensive rats. Stroke-prone rats were randomly divided into a control group, an sham group. Motor function measured using grip strength test. Axon myelin markers, growth-associated protein 43, basic protein, Tau,...
Abstract Rectal cancer is a common malignant tumour and the progression highly affected by microenvironment (TME). This study intended to assess relationship between TME prognosis, explore prognostic genes of rectal cancer. The gene expression profile was obtained from TCGA immune/stromal scores were calculated Estimation Stromal Immune cells in Malignant Tumors using Expression data (ESTIMATE) algorithm. correlation survival time as well clinical characteristics evaluated. Differentially...
Poststroke cognitive impairment (PSCI) often occurs during the stroke recovery period and greatly increases difficulty of rehabilitation. Activation neuroinflammation long-term changes in gene expression patterns hippocampus could be essential development PSCI. Therefore, this study aimed to identify rats with Rats underwent transient middle cerebral artery occlusion (tMCAO) or sham surgery. The infarct volume was measured on day 3 after Morris water maze (MWM) test used assess function....
Recently, transformers have shown great potential in image classification and established state-of-the-art results on the ImageNet benchmark. However, compared to CNNs, converge slowly are prone overfitting low-data regimes due lack of spatial inductive biases. Such biases can be especially beneficial since 2D structure an input is not well preserved transformers. In this work, we present Spatial Prior-enhanced Self-Attention (SP-SA), a novel variant vanilla (SA) tailored for vision Priors...
Running wheel exercise training (RWE) and skilled reaching (SRT) are physical approaches with positive effects on cognitive function. However, few studies have compared the different of these exercises long-term memory, their mechanism remains unknown. This study investigated SRT RWE, at recovery stage, function transient middle cerebral artery occlusion (tMCAO) rats explored association NgR1/Rho-A/ROCK/LOTUS/LGI1 signaling. Adult Sprague-Dawley (n = 55) were divided into four groups after...
Multimodal learning, integrating histology images and genomics, promises to enhance precision oncology with comprehensive views at microscopic molecular levels. However, existing methods may not sufficiently model the shared or complementary information for more effective integration. In this study, we introduce a Unified Modeling Enhanced Learning (UMEML) framework that employs hierarchical attention structure effectively leverage features of both modalities genomics. Specifically, mitigate...
Cerebral ischemia is considered to be the most common cause of stroke with high mortality. It occurs as a result damage hippocampal neurons lymphocyte function-associated antigen (LFA)-1 being emphasized play role in biological functions neurons. This study was conducted order investigate effects specific knockdown LFA-1 expression by lentivirus had on apoptosis neurons, simulated rat models acute cerebral after lymphatic blockage.A total 60 Wistar rats were selected subjects, among which 50...