A5001036306- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Congenital Diaphragmatic Hernia Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Radiomics and Machine Learning in Medical Imaging
- Gastroesophageal reflux and treatments
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Long-Term Effects of COVID-19
- Flavonoids in Medical Research
- Ferroptosis and cancer prognosis
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Respiratory Support and Mechanisms
- Catalysts for Methane Reforming
- Cancer Immunotherapy and Biomarkers
- Anesthesia and Neurotoxicity Research
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- Insects and Parasite Interactions
Harbin Engineering University
2024-2025
Qilu University of Technology
2024
Harbin Medical University
2018-2024
Third Affiliated Hospital of Harbin Medical University
2018-2024
Shandong Academy of Sciences
2024
The First Hospital of Changsha
2014-2023
Central South University
2011-2014
Second Xiangya Hospital of Central South University
2011-2014
Abstract Circular RNAs (circRNAs) have been identified play a vital role in various different types of cancer via sponging miRNAs (microRNAs). However, their lung adenocarcinoma (LUAD) remains largely unclear. In this study, we systematically characterized the circRNA expression profiles LUAD tissues and paired adjacent non-cancerous tissues. Three circRNAs were found to be significantly upregulated. Among them, has-circRNA-002178 was further confirmed upregulated tissues, cells....
Non-small cell lung cancer (NSCLC) is the predominant form of and one most fatal cancers worldwide. Recently, International Association for Study Lung Cancer (IASLC) proposed a novel grading system based on high-grade histological patterns invasive pulmonary adenocarcinoma (IPA). To improve outcomes NSCLC patients, we combined serum metabolomics fecal microbiology to screen biomarkers in patients with early-stage identified characteristic microbial profiles different grades IPA. 26 genera...
Backgrounds and Purpose The theory of “entero-pulmonary axis” proves that pneumonia leads to gut microbiota disturbance Treg/Th17 immune imbalance. This study is aimed explore the potential mechanism fecal transplantation (FMT) in treatment Pseudomonas aeruginosa pneumonia, order provide new insights into pneumonia. Methods C57/BL6 mice were used construct acute mouse model, FMT was treated. Histopathological changes lung spleen observed by HE staining. expression CD25, Foxp3 IL-17...
Gastroesophageal reflux impairs the mucosal barrier in distal esophagus, allowing chronic exposure of squamous epithelium to multitudinous stimulations and inducing inflammation.Esophagitis is a response inflammation esophageal mucosa.Our study clarified that alcohol accumulation could aggravate progress esophagitis by pyroptosis; however, Ac-YVAD-CMK, an inhibitor caspase-1, effectively suppress expression IL-1β IL-18 both vivo vitro, reducing inflammatory response, which promised be agent...
Background Pulmonary fibrosis is one of the sequelae COVID-19, which seriously affects quality life survivors. Currently, there are no optimal evidence based guidelines targeting this population. Case Presentation We report a 66-year-old female patient without underlying comorbidities admitted to Changsha Public Health Center because COVID-19. During hospitalization, she developed co-bacterial infection and acute respiratory distress syndrome, received broad-spectrum antibacterial therapy,...
Accumulating evidence suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impairs the adaptive immune system during infection. Still, it remains largely unclear whether frequency and functions of T B cells return to normal after recovery Coronavirus Disease 2019 (COVID-19). Here, we analyzed repertoires SARS-CoV-2-specific neutralization antibodies in a prospective cohort 40 COVID-19 survivors with 6-month follow-up hospital discharge. Immune repertoire sequencing...
Abnormal apoptotic events play an important role in the pathogenesis of emphysema. The B-cell CLL/lymphoma 2 (Bcl-2) family proteins are essential and critical regulators apoptosis. We determined whether anti-apoptotic Bcl-2 a cigarette smoke extract (CSE)-induced Furthermore, given involvement epigenetics chronic obstructive pulmonary disease, we hypothesized that deregulation might be caused by gene methylation. emphysema BALB/C mice was established intraperitoneally injection CSE....
Lung cancer is the most prevalent and deadly tumors around world. Here we aimed to investigate effect of wogonoside (also called baicalin) on invasion migration lung A549 cells angiogenesis in xenograft nude mice.A549 were treated with different doses wogonoside. After 24 h, CCK8 was used detect survival rate cells. The non-toxic (0, 10, 25, 50 µM) selected for subsequent experiments. Transwell scratch assays migration. number microtubule nodules detected by formation experiment, expressions...
Abstract Objective To explore the independent predictors of pathological mediastinal lymph node (pN2) metastasis in clinical stage IA (cIA) pure-solid non-small cell lung cancer (NSCLC) patients, and to find an appropriate method dissection. Methods This study retrospectively evaluated 533 cIA NSCLC patients who underwent radical resection (lobectomy combined with systematic dissection) from January 2014 December 2016. The relationship between clinicopathological characteristics pN2 was...
The present case described a 70-year-old male who was initially diagnosed and treated as acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Ultimately Lophomonas blattarum (L. blattarum), rare protozoan causing opportunistic infection, found in suction sputum smear. Bronchoscopy showed lot purulent airways, diffusely swelling friable mucus on bronchus. After single tinidazole treatment, symptoms image marked improvement. It indicates though the untraditional...
Objective: To explore the clinical characteristics, imaging findings, laboratory tests and treatment strategies for Chlamydia psittaci pneumonia. Methods: From January 1, 2019 to 20, 2021, 48 cases of Psittacosis from 11 hospitals in China were diagnosed via metagenomic next-generation sequencing(mNGS). The data all patients on occupational history, manifestations, tests, chest computed tomography(CT)findings, outcomes prognosis retrospectively analyzed. Results: Among patients, there 29...
Introduction: Tuberculosis (TB) is an infectious disease caused by a bacterium called Mycobacterium tuberculosis ( Mtb ). Previous studies have primarily focused on the transmissibility of multidrug-resistant (MDR) or extensively drug-resistant (XDR) . However, variations in virulence across lineages may also account for differences transmissibility. In , polyketide synthase (PKS) genes encode large multifunctional proteins which been shown to be major mycobacterial factors. Therefore, this...
Abstract Objectives Uniportal video-assisted thoracoscopic surgery pneumonectomy (U-VATS-P) is feasible and safe from a perioperative standpoint. How to choose the proper chest tube drainage method important in enhanced recovery after (ERAS) protocols. In this study, we aimed assess safety of one 8.5-Fr (1Fr = 0.333 mm) pigtail catheter for postoperative continuous open gravity U-VATS-P. Methods We retrospectively reviewed single surgeon’s experience with U-VATS-P lung cancer May 2016...
Introduction . Preoperative detection of pleural invasion in lung cancer patients is key to curative surgical treatment. We tried predict non-small-cell with <100 ml fluid. Methods. Patients admitted from August 1, 2011, December 31, 2018, were retrospectively retrieved. Records serum and imaging markers analyzed. Results. Among 7004 who received surgery, 43 cases fluid had included, another 108 without enrolled as controls. There no differences squamous cell carcinoma antigen (SCC) or...
Lung cancer (LC) is one of the malignant tumors with growing morbidity and mortality. The involvement runt-related transcription factor 1 (RUNX1) in LC patients has been elucidated. We intended to research mechanisms RUNX1 tartrate-resistant acid phosphatase 5 (ACP5) LC. Firstly, ACP5 levels tissues, paracancerous cells tracheal epithelial were detected. overexpression plasmid interference constructed transfected into 95C A549 cells, respectively. binding promoter was tested. Additionally,...
Abstract Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer. Most patients are diagnosed at an advanced stage, therefore it crucial to identify novel prognostic biomarkers for LUAD. As important regulatory cells, inducible T cells (iTregs) play a vital role in immune suppression and maintenance homeostasis. This study explored value therapeutic effects iTreg‐related genes Data LUAD patients, including infiltration data, RNA sequencing clinical features, were acquired from...
With the advantages of better cosmetic incision and faster recovery, uniportal video-assisted thoracoscopic surgery (UP-VATS) has developed rapidly worldwide in recent decades, indications for UP-VATS have been further expanded to those conventional VATS. Complex segmentectomy that makes several or intricate intersegmental planes, with more complex procedures, continues be difficult minimally invasive techniques. However, there are few reports on segmentectomy. In this report, we describe...
This paper summarizes NEC non-noble metal hydrogenation catalysts' latest research, covering synthesis, structural features, hydrogen storage performance and development prospect. The aim is to boost catalyst research application.
To test the association of K469E, common intercellular adhesion molecule-1 (ICAM-1) polymorphism with chronic obstructive pulmonary disease (COPD) and expression ICAM-1 in Han people Central South Region China.A case-control study was done on 91 patients COPD 80 matched controls from central south region China, mainly Hunan Province. Genomic DNA extracted white blood cells. sequences were amplified by PCRand analyzed agarose gel electrophoresis. Genotypes defined base sequencing. In...
<title>Abstract</title> <bold>OBJECTIVES</bold> Uniportal video-assisted thoracoscopic surgery pneumonectomy (U-VATS-P) is feasible and safe from a perioperative standpoint in clinical practice. How to choose proper chest tube drainage method an important step enhanced recovery after (ERAS) protocols. In this study, we aimed assess the safety of one 8.5-Fr (1Fr = 0.333mm) pigtail catheter for postoperative continuous open gravity U-VATS-P. <bold>METHODS</bold> We retrospectively reviewed...
Cytochrome P450 2A6 (CYP2A6) plays a major role in the metabolism of nicotine,which has dozens genotypes. Recently researches focus on relationship between CYP2A6 gene polymorphism and smoking behavior, have found that activity is related to success cessation. Hence it maybe responsible for choose quiting smoking. Key words: Cytochrome ; Nicotine; Smoking behavior; cessation