Background: Coronavirus disease 2019 (COVID-19) and tuberculosis (TB) are two major infectious diseases posing significant public health threats, their coinfection (aptly abbreviated COVID-TB) makes the situation worse. This study aimed to investigate clinical features prognosis of COVID-TB cases. Methods: The PubMed, Embase, Cochrane, CNKI, Wanfang databases were searched for relevant studies published through December 18, 2020. An overview case reports/case series was prepared that...

Abstract Background To explore population aging and the epidemic trend of pulmonary tuberculosis (PTB) in elderly, provide a basis for prevention control among elderly. Methods We collected clinical information 239,707 newly active PTB patients Shandong Province from 2005 to 2017. analyzed compared characteristics, reported incidence temporal elderly group (≥60 years) non-elderly (< 60 through logistic model Join-point regression model. Results Among total cases, 77,192(32.2%) were...

Abstract Although afforestation of nitrogen‐fixing shrubs, especially Caragana korshinskii in semiarid areas, is expected to improve ecosystem restoration and carbon sequestration, water shortage induced by these thirsty shrubs may negate potential benefits. Yet there poor understating the persistence soil sequestration shrub plantations. Here, we selected three C. plantations with different ages (10, 20, 30 years) on Loess Plateau evaluate sink. We examined dynamics carbon, total nitrogen,...

Introduction Tuberculosis is one of the main infectious diseases threatening global health, which also cause death from a single source infection (above HIV/AIDS). China country with high burden tuberculosis in world, ranking only behind India and Indonesia. However, there are few ecological studies on China. This study aims to provide more research basis for government formulate policies by exploring factors associated incidence tuberculosis, so as achieve goal eliminating 2030. Methods We...

Objective This study was designed to identify the risk factors for drug-resistant tuberculosis (DR-TB) and association between comorbidity drug resistance among retreated pulmonary (PTB). Design A retrospective conducted all 36 monitoring sites in Shandong, China, over a 16-year period. Baseline characteristics were collected from TB Surveillance System. Categorical variables compared by Fisher’s exact or Pearson’s χ 2 test. The identified using univariable analysis multivariable logistic...

Abstract Background Drug-resistant tuberculosis (DR-TB), obesity, and malnutrition are growing public health problems in the world. However, little has discussed impact of different BMI status on emergence TB drug resistance. We aimed to explore drug-resistant profiles DR-TB its clinical predictors among underweight, overweight or obesity population. Methods 8957 newly diagnosed cases with susceptibility results data Shandong China, from 2004 2019 were enrolled. Multivariable univariable...

Background: With an aging population, China is facing a huge burden of elderly patients with drug resistant tuberculosis (DR-TB), which has become significant obstacle for the global TB control. There still little study on DR-TB in so far. Thus, more research epidemiological characteristics and trend primary among will be necessary. Methods: A retrospective was conducted Shandong, from 2004 to 2019. We collected 12,661 cases, 4368 (≥ 60 years) cases were involved. Clinical including age,...

Introduction: Tuberculosis (TB) is an infectious disease caused by a bacterium called Mycobacterium tuberculosis ( Mtb ). Previous studies have primarily focused on the transmissibility of multidrug-resistant (MDR) or extensively drug-resistant (XDR) . However, variations in virulence across lineages may also account for differences transmissibility. In , polyketide synthase (PKS) genes encode large multifunctional proteins which been shown to be major mycobacterial factors. Therefore, this...

Abstract Background Tuberculosis (TB) is one of the major infectious diseases that seriously endanger people’s health. In Shandong province, relationship between level economic development and TB incidence has not been studied. This study aims to provide more research basis for government prevent control by exploring impact different factors on incidence. Methods By constructing threshold regression model (TRM), we described extent which contribute registered differences in among seventeen...

Objectives To investigate the independent and collective impact of alcohol drinking tobacco smoking on drug-resistance newly diagnosed tuberculosis (TB). Design This was a retrospective cohort study. Setting Shandong, China. Participants Patients with TB from 1 January 2004 to 31 December 2020 were collected. Exclusive criteria: retreated cases; extrapulmonary tuberculosis; without information drug susceptibility testing results, or habits; bacteriological identification as non-tuberculous...

Tuberculosis (TB) is one of the main infectious diseases that seriously threatens global health, while diagnostic delay (DD) and treatment dramatically threaten TB control. Between 2005 2017 in Shandong, China, we enrolled pulmonary tuberculosis (PTB) patients with DD. DD trends were evaluated by Joinpoint regression, associations between PTB patient characteristics estimated univariate multivariate logistic regression. The influence duration on prognosis sputum smear results assessed...

Abstract Background Considering the high morbidity and mortality of lung cancer incidence pulmonary nodules, clearly distinguishing benign from malignant nodules at an early stage is great significance. However, determining kind nodule which more prone to remains a problem worldwide. Methods A total 480 patients with data were collected Shandong, China. We assessed clinical characteristics computed tomography (CT) imaging features among in who had undergone video‐assisted thoracoscopic...

Drug-resistant tuberculosis (DR-TB), diabetes and exposure to air pollution are thought be important threat human health, but no studies have explored the effects of ambient pollutants on DR-TB when adjusting status so far. We performed a study among 3759 newly diagnosed TB cases with drug-susceptibility testing results, status, individual data in Shandong from 2015 2019. Generalized linear mixed models (GLMM) including three (Model 1: without covariates, Model 2: adjusted by only, 3: all...

Abstract Background Pyrazinamide (PZA) is essential for the treatment of drug-susceptible and drug-resistant tuberculosis (TB), especially multidrug-resistant (MDR) TB, but condition PZA resistance (PZA-R) across China unknown. Our aim to clarify genetic mutations PZA-R relationship between MDR-TB in China, from 2007 2019. Methods A total 3202 TB strains with gene sequences results were included, among which 1447 sequenced 1775 download European Nucleic Acid Sequence Database. Drug was...

Purpose:To analyze the time trends in notification rates of registered tuberculosis (TB) and bacteriologically confirmed TB Shandong Province.And changes treatment outcomes during 2005-2021.Patients Methods: The information patients Information Center for Disease Control Prevention (CDC) was collected 2005-2021.We calculated TB.Moreover, we year-to-year change rate before after COVID-19.The were analyzed using joinpoint regression method illustrated as annual percentage (APC) rates.Results:...

Abstract Background Fatty acid metabolism greatly promotes the virulence and pathogenicity of Mycobacterium tuberculosis ( M.tb ). However, regulatory mechanism fatty in remains to be elucidated, limited evidence about effects gene mutations on transmission was reported. Results Overall, a total 3193 isolates were included study, which 1596 (50%) genomic clustered isolates. Most belonged lineage2( n = 2744,85.93%), followed by lineage4( 439,13.75%) lineage3( 10,0.31%).Regression results...

Abstract Background: Finding out more predictors of drug-resistant tuberculosis (DR-TB) helps to facilitate TB prevention and control. Previous study had revealed that tobacco smoking alcohol drinking might be a risk factor for developing tuberculosis. However, few discussed their joint impact on resistance among newly diagnosed cases. This aimed assess compare the independent effect resistance. Methods: was retrospective 7996 patients who were collected from Shandong, China Jan 1, 2004, Dec...

The physical bookstore is an important terminal for the realization of economic value and cultural value.However, with development online bookstores e-books, share in book market was squeezed.The relationship between consumer behavior management has not been verified.Therefore, based on theory, purpose this paper to study consumers bookstores, improve from 4V strategy.The collect data related their interrelationships using VAR models tests.My research results show that income affected by...

Abstract Background: With an aging population, China is facing a huge buedern of elderly patients with drug resistant tuberculosisi (DR-TB), which has become significant obscale for the global TB control targets. There still few study on DR-TB among so far.Thus, more researches epidemiological characteristics and trend primary will be necessary. Methods: A retrospective was conducted in Shandong, from 2004-2019, 12661 4368 (≥60 years age) cases were involved. Clinical including age, sex,...

Abstract Background : Tuberculosis (TB) is one of the major infectious diseases that seriously endanger people's health.In Shandong province, relationship between level economic development and TB incidence has not been studied.This study aims to provide more research basis for government prevent control by exploring impact different factors on incidence. Methods By constructing threshold regression model (TRM),we described extent which contribute registered differences in among seventeen...

Abstract Background: With an aging population, China is facing a huge buedern of elderly patients with drug resistant tuberculosisi (DR-TB), which has become significant obscale for the global TB control targets. There still few study on DR-TB among so far.Thus, more researches epidemiological characteristics and trend primary will be necessary. Methods: A retrospective was conducted in Shandong, from 2004-2019, 12661 4368 (≥60 years age) cases were involved. Clinical including age, sex,...