A5115595966- Internet Traffic Analysis and Secure E-voting
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Network Security and Intrusion Detection
- Advanced Text Analysis Techniques
- Cryptography and Data Security
- Systemic Lupus Erythematosus Research
- Autophagy in Disease and Therapy
- Text and Document Classification Technologies
- Animal Disease Management and Epidemiology
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Sentiment Analysis and Opinion Mining
- SARS-CoV-2 and COVID-19 Research
- Topic Modeling
- Domain Adaptation and Few-Shot Learning
- Advanced Malware Detection Techniques
- Atherosclerosis and Cardiovascular Diseases
- Bacteriophages and microbial interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Endoplasmic Reticulum Stress and Disease
- IL-33, ST2, and ILC Pathways
- interferon and immune responses
Sichuan University
2015-2025
Anhui Medical University
2024-2025
Army Medical University
2024-2025
Xi'an Jiaotong University
2017-2025
Xi'an Honghui Hospital
2017-2025
Agro-Environmental Protection Institute
2024-2025
Ministry of Agriculture and Rural Affairs
2024-2025
Southwest Hospital
2025
Southwest General Health Center
2025
Shandong University
2024
Recently, multi-view representation learning has become a rapidly growing direction in machine and data mining areas. This paper introduces two categories for learning: alignment fusion. Consequently, we first review the representative methods theories of based on perspective alignment, such as correlation-based alignment. Representative examples are canonical correlation analysis (CCA) its several extensions. Then from fusion investigate advancement that ranges generative including...
Abstract Absent in melanoma 2 (AIM2) has been reported to be a component of inflammasomes innate immune cells. Surprisingly, AIM2 is expressed by B cells, and higher expression observed the cells from lupus patients. To date, inflammasome-independent function remains unclear. Here, we report increased human tonsil memory germinal center (GC) plasma circulation skin lesions Conditional knockout reduces CD19 + B-cell frequency lymph nodes spleens, dampens KLH-induced IgG1-antibody production....
This study showed PEHCl-CN can enhance the strength of Sn–I, resulting in good light stability. The subsequent doping MBI resulted air enables integrated 2T all-perovskite device to achieve an efficiency 27.9%.
Methicillin-resistant Staphylococcus aureus (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn2+ vancomycin (Van) codelivered nanotherapeutic (named Man-Zn2+/Van NPs) was fabricated characterized via mannose (Man) modification. NPs exhibit significant inhibitory activity against extra- MRSA obviously decrease minimum concentration Van. can be...
Abnormalities in glycolytic pathways are prominent factors the pathogenesis of osteoarthritis (OA). The key enzyme Hexokinase 2 (HK2) is highly expressed chondrocytes OA; however, its role remains unclear. Pulsed electromagnetic field (PEMF) commonly used for treatment OA. However, PEMF cartilage damage and underlying mechanisms not well understood. Herein, we found that HK2 suppression down-regulated catabolic alleviated inflammatory responses OA chondrocytes, whereas overexpression...
The accumulation of intracellular reactive oxygen species (ROS) is widely recognized to stimulate the development osteoclasts, a crucial factor in onset osteoporosis. ROS scavenging capability Prussian blue nanoparticles (PBNPs) exceptional, and they possess excellent biocompatibility. However, effects PBNPs on osteoporosis remain unknown. Present study aimed investigate whether could inhibit osteoclast differentiation prevent ovariectomy (OVX)-induced bone loss by suppressing ROS. In vitro...
<title>Abstract</title> The full text of this preprint has been withdrawn by the authors due to author disagreement with posting preprint. Therefore, do not wish work be cited as a reference. Questions should directed corresponding author.
ABSTRACT Bone marrow mesenchymal stem cells (BM‐MSCs) have promising prospects in bone repair and regenerative medicine. However, BM‐MSCs gradually lose their original pluripotency differentiation potential after successive passages. This study aimed to reveal the mechanism underlying phenomenon. Western blotting, SA‐β‐gal staining Alizarin red were used evaluate senescence phenotype osteogenic ability. Mitochondrial ROS levels detected using flow cytometry. Protein interactions...
Earthworm gut digestion plays a crucial role in reducing antibiotic resistance genes (ARGs) during vermicomposting, offering significant potential for controlling ARG dissemination livestock manure. However, the impact of residual tetracycline antibiotics on this process remains poorly understood. Herein, study systematically evaluated three concentrations (0, 10, and 100 mg/kg) dynamics microbial community evolution 35-day vermicomposting cattle The results demonstrated that earthworm...
Abstract Background: Her2 and c-Met, two tumor-associated antigens (TAAs), are well-established cancer targets, as evidenced by the approval of several anti-Her2 antibody-drug conjugates (ADCs), a bispecific anti-c-Met/EGFR antibody, promising Phase 2 efficacy an anti-c-Met ADC. c-Met expressed separately or co-expressed in various types, including lung, pancreatic kidney cancers, reflecting heterogeneity tumor TAA expression. Dual TAA-targeting may reduce probability escape, commonly seen...
Abstract Mitochondria-associated endoplasmic reticulum membranes (MAMs) regulate ATG14- and Beclin1-mediated mitophagy play key roles in the development of diabetic nephropathy (DN). DsbA-L is mainly located MAMs plays a role renoprotection, but whether it activates by maintaining MAM integrity remains unclear. In present study, we found that renal tubular damage was further aggravated DsbA-L−/− mice compared with this accompanied disrupted decreased mitophagy. Furthermore, notably...
The performance of an automated commercial CRISPR/Cas based technology was evaluated and compared with routine RT-PCR testing to diagnose COVID-19. Suspected discharged COVID-19 cases were included tested CRISPR-based SARS-CoV-2 test assay using throat swab sputum specimens. diagnostic yield calculated the McNemar test. A total 437 patients for analysis, including (n = 171), 155), others 111). For diagnosis COVID-19, CRISPR-SARS-CoV-2 had a sensitivity specificity 98.2% (168/171) 100.0%...