A5101969237- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- IL-33, ST2, and ILC Pathways
- Telomeres, Telomerase, and Senescence
- Immunotherapy and Immune Responses
- interferon and immune responses
- Immune Response and Inflammation
- Dermatology and Skin Diseases
- Inflammasome and immune disorders
- Lymphoma Diagnosis and Treatment
- Extracellular vesicles in disease
- Skin Protection and Aging
- Diabetes and associated disorders
- Infectious Diseases and Mycology
- Advanced biosensing and bioanalysis techniques
- Eosinophilic Disorders and Syndromes
- Skin Diseases and Diabetes
- Vasculitis and related conditions
- Genomics, phytochemicals, and oxidative stress
- FOXO transcription factor regulation
- Peripheral Neuropathies and Disorders
- Oral Health Pathology and Treatment
Second Xiangya Hospital of Central South University
2010-2025
Central South University
2010-2025
First Affiliated Hospital Zhejiang University
2021-2024
Zhejiang University
2022-2024
Hangzhou Cancer Hospital
2024
China Pharmaceutical University
2023
Zhejiang Lab
2022
Second Affiliated Hospital of Zhejiang University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2020
Hunan Normal University
2020
Abstract Follicular helper T cells (Tfh) have been well documented to play a critical role in autoimmunity, such as systemic lupus erythematosus (SLE), by helping B cells. In this study, high salt (sodium chloride, NaCl), under physiological conditions, was demonstrated increase the differentiation of Tfh. A high-salt diet markedly increased features MRL/lpr mice. The mechanism is NaCl-induced DNA demethylation via recruitment hydroxytransferase Ten-Eleven Translocation 2 (TET2). Gene...
Immunity following an acutely resolved infection or the long-term equipoise of chronic viral infections often depends on maintenance antigen-specific CD8+ T cells, yet ongoing transcriptional requirements these cells remain unclear. We show that active and continuous programming by FOXO1 is required for functional a memory population. Upon Foxo1 deletion resolution infection, rapidly lost their characteristic gene expression, gradually declined in number, were impaired self-renewal. This was...
Messenger RNA (mRNA)-based vaccines have enormous potential in infectious disease prevention and tumor neoantigen application. However, developing an advanced delivery system for efficient mRNA intracellular release protein translation remains a challenge. Herein, biocompatible biomimetic is designed using red blood cell-derived nanoerythrosomes (NER) black phosphorus nanosheets (BP) delivery. BP covalently modified with polyethyleneimine (PEI), serving as core to efficiently condense via...
Abstract Background Basal cell carcinoma (BCC) is the most common skin cancer. Recently, aminolaevulinic acid-photodynamic therapy (ALA-PDT) has emerged as a non-invasive treatment for facial lesions. Objectives This research aimed to evaluate efficacy and safety of second-intention healing after tumor excision with ALA-PDT in periocular BCC. Methods A total 16 patients BCC from an academic, large metropolitan-based hospital were included this study. All received marginal resection combined...
Few studies have analyzed the clinicopathologic characteristics and outcomes of lupus nephritis (LN) patients with antineutrophil cytoplasmic antibody (ANCA). The clinical renal histopathologic data 154 biopsy-proven LN from 2011 to 2013 were retrospectively. followed up for a median period 16.8 ± 9.4 months, their analyzed. Multivariate Cox analysis was used evaluate independent factors poor outcomes. Among patients, 26 (16.88%) seropositive ANCA. incidences alopecia, oral ulcer,...
Although the original purpose of systemic lupus erythematosus (SLE) classification criteria was to distinguish SLE from other mimic diseases, and facilitate sample selection in scientific research, they have become widely used as diagnostic clinical situations. It is not known yet if regarding criteria, what problems might be encountered? This first study comparing three sets for SLE, 1997 American College Rheumatology (ACR’97), 2012 Systemic Lupus International Collaborating Clinics...
Purpose: Amyopathic dermatomyositis (ADM) is a rare, idiopathic, connective tissue disease and melanoma differentiation-associated protein 5 (MDA5) antibody-positive ADM more treatment-resistant, especially in patients with interstitial lung (ILD). The purpose of this article to report case anti-MDA5-positive successfully treated JAK inhibitor Upadacitinib.
Objective Lupus erythematosus (LE) is a complicated disease with highly heterogeneous clinical manifestations. Previous studies have rarely included all subgroups of patients lupus and overlooked the importance cutaneous manifestations thereof. We aimed to compare demographic differences among different subtypes lupus. Methods This first real-world study relatively large sample size that simultaneously includes isolated (iCLE) SLE. All samples were obtained from Erythematosus Multicenter...
Abstract Caspase-8 (CASP8) is known as an executioner of apoptosis, but more recent studies have shown that it participates in the regulation necroptosis and innate immunity. In this study, we show CASP8 negatively regulates retinoic acid–inducible gene I (RIG-I) signaling such that, its absence, stimulation RIG-I pathway dendritic cells (DCs) produced modestly enhanced activation IFN regulatory factor 3 with correspondingly greater amounts proinflammatory cytokines. addition, mice lacking...
MicroRNA-98-5p (miR-98-5p) plays a protective role in the pathogenesis of autoimmune diseases through anti-inflammatory effects, but little is known about its Systemic lupus erythematosus (SLE). Our previous study suggested Interferon-inducible 44 like (IFI44L) overexpressed monocytes which contributes to SLE by enhancing maturation and functions monocyte-derived dendritic cells (Mo-DCs), miR-98-5p can regulate expression IFI44L. In this study, we identified lowly expressed both peripheral...