A5070641855- Molecular Junctions and Nanostructures
- Quantum and electron transport phenomena
- X-ray Diffraction in Crystallography
- Gut microbiota and health
- Advanced biosensing and bioanalysis techniques
- Crystallization and Solubility Studies
- Organic Electronics and Photovoltaics
- Mycobacterium research and diagnosis
- Conducting polymers and applications
- Electrochemical sensors and biosensors
- Force Microscopy Techniques and Applications
- Systemic Lupus Erythematosus Research
- Electrochemical Analysis and Applications
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- DNA and Nucleic Acid Chemistry
- Clostridium difficile and Clostridium perfringens research
- Nanowire Synthesis and Applications
- Machine Learning in Materials Science
- Autophagy in Disease and Therapy
- Advanced Photocatalysis Techniques
- Plant biochemistry and biosynthesis
- Nanomaterials for catalytic reactions
- Advancements in Battery Materials
- Microscopic Colitis
Peking University
2024
Affiliated Hospital of Southwest Medical University
2024
Southwest Medical University
2024
Second Xiangya Hospital of Central South University
2018-2023
Central South University
2018-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
Peking Union Medical College Hospital
2022
Harvard University
2022
Brown University
2019-2022
China University of Mining and Technology
2022
Graphene has a unique atom-thick two-dimensional (2D) structure, high conductivity and charge mobility, huge specific surface area, excellent mechanical, thermal electrical properties. Thus, it been regarded as an important component for functional materials, especially developing variety of catalysts. In this review, we summarize the recent advancements in synthesizing graphene based new catalysts, their applications organic synthesis, sensors, environmental protection energy related systems.
We report a combined experimental and theoretical investigation of the length dependence anchor group electrical conductance series oligoyne molecular wires in single-molecule junctions with gold contacts. Experimentally, we focus on synthesis properties diaryloligoynes n = 1, 2, 4 triple bonds dihydrobenzo[b]thiophene (BT). For comparison, also explored aurophilic cyano (CN), amino (NH2), thiol (SH), 4-pyridyl (PY). Scanning tunneling microscopy break junction (STM-BJ) mechanically...
A graphene oxide/hemoglobin (GO/Hb) composite hydrogel was prepared for catalyzing a peroxidatic reaction in organic solvents with high yields, exceptional activity and stability.
A quantum circuit rule for combining interference effects in the conductive properties of oligo(phenyleneethynylene) (OPE)-type molecules possessing three aromatic rings was investigated both experimentally and theoretically. Molecules were type X-Y-X, where X represents pyridyl anchors with para (p), meta (m) or ortho (o) connectivities Y a phenyl ring p m connectivities. The conductances GXmX (GXpX) form X-m-X (X-p-X), (para) connections central ring, predominantly lower (higher),...
Abstract The structures and mechanism of action many terpene cyclases are known, but no diterpene have yet been reported. Here, we propose structural models based on bioinformatics, site‐directed mutagenesis, domain swapping, enzyme inhibition, spectroscopy that help explain the nature cyclase structure, function, evolution. Bacterial contain ∼20 α‐helices same conserved “QW” DxDD motifs as in triterpene cyclases, indicating presence a βγ barrel structure. Plant similar catalytic motif...
The synthesis is reported of a new series oligo(aryleneethynylene) (OAE) derivatives up to ca. 6 nm in molecular length (OAE9) using iterative Pd-mediated Sonogashira cross-coupling methodology. oligo-p-phenyleneethynylene cores the wires are functionalized at both termini with pyridyl units for attachment gold leads. structures determined by single-crystal X-ray analysis OAE4, OAE5, OAE7, and OAE8a. charge transport characteristics OAE3–OAE9 single-molecular junctions have been studied...
Controlling charge transport through a single molecule connected to metallic electrodes remains one of the most fundamental challenges nanoelectronics. Here we use electrochemical gating reversibly tune conductance two different organic molecules, both containing anthraquinone (AQ) centers, over >1 order magnitude. For electrode potentials outside redox-active region, effect gate is simply shift molecular energy levels relative metal Fermi level. At redox potential, changes abruptly as AQ...
The understanding of the charge transport through single molecule junctions is a prerequisite for design and building electronic circuits based on junctions. However, reliable robust formation such challenging task to achieve. In this topical review, we present systematic investigation anchoring group effect junction conductance by employing two complementary techniques, namely scanning tunneling microscopy break (STM-BJ) mechanically controllable (MCBJ) studies published in literature...
Abstract Charge transport by tunnelling is one of the most ubiquitous elementary processes in nature. Small structural changes a molecular junction can lead to significant difference single-molecule electronic properties, offering tremendous opportunity examine reaction on scale monitoring conductance changes. Here, we explore potential break technique detection photo-thermal photochromic dihydroazulene/vinylheptafulvene system. Statistical analysis experiments provides quantitative approach...
T cell receptor (TCR) diversity determines the autoimmune responses in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) is closely associated with diseases prognosis prevention. However, characteristics of variations TCR their clinical significance still unknown. Large series patients must be studied order to elucidate effects these variations.Peripheral blood from 877 SLE patients, 206 RA 439 healthy controls (HC) were amplified for repertoire sequenced using a...
Epigenetic modifications affect the differentiation of T cell subsets and pathogenesis autoimmune diseases, but many mechanisms epigenetic regulation are unclear. Here we show reduced expression transcription factor RFX1 in CD4+ cells from patients with systemic lupus erythematosus, which leads to IL-17A overexpression through increased histone H3 acetylation decreased DNA methylation H3K9 tri-methylation. Conditional deletion Rfx1 mice exacerbates experimental encephalomyelitis...
ZnO nanoparticles (NPs) were synthesized using a hydrothermal method. Scanning electron microscope (SEM) and X-ray diffraction have been used for characterizing the NPs. An electrochemical sensor was fabricated NPs–modified glassy carbon electrode simultaneous determination of ascorbic acid (AA), dopamine (DA), uric (UA). The proposed exhibited excellent detection performance toward three analytes, demonstrating that it can potentially be applied in clinical applications. results indicated...
Experiments using a mechanically controlled break junction and calculations based on density functional theory demonstrate new magic ratio rule (MRR) that captures the contribution of connectivity to electrical conductance graphene-like aromatic molecules. When one electrode is connected site i other i′ particular molecule, we assign molecule "magic integer" Mii′. Two molecules with same core but different pairs connection sites (i,i′ j,j′, respectively) possess integers Mii′ Mjj′. On basis...
Abstract We studied the single‐molecule conductance through an acid oxidant triggered phenothiazine (PTZ‐) based radical junction using mechanically controllable break technique. The electrical of state was enhanced by up to 200 times compared neutral state, with high stability lasting for at least two months and formation probability room‐temperature. Theoretical studies revealed that increase is due a significant decrease HOMO–LUMO gap also transmission close HOMO orbital when forms. large...
If quantum interference patterns in the hearts of polycyclic aromatic hydrocarbons could be isolated and manipulated, then a significant step toward realizing potential single-molecule electronics would achieved. Here we demonstrate experimentally theoretically that simple, parameter-free, analytic theory evaluated at mid-point HOMO–LUMO gap (referred to as M-functions) correctly predicts conductance ratios molecules with pyrene, naphthalene, anthracene, anthanthrene, or azulene hearts....
Diallyl disulfide (DADs), a natural organic compound, is extracted from garlic and scallion has anti-tumor effects against various tumors. This study investigated the activity of DADs in human osteosarcoma cells mechanisms. MG-63 were exposed to (0, 20, 40, 60, 80, 100 μM) for different lengths time (24, 48, 72 h). The CCK8 assay results showed that inhibited cell viability dose-and time-dependent manner. FITC-Annexin V/propidium iodide staining flow cytometry demonstrated apoptotic ratio...
Prostate cancer (PCa) is witnessing a concerning rise in incidence annually, with the androgen receptor (AR) emerging as pivotal contributor to its growth and progression. Mounting evidence underscores AR's ability recruit cofactors, influencing downstream gene transcription thereby fueling proliferation metastasis of PCa cells. Although, clinical strategies involving AR antagonists provide some relief, managing castration resistant prostate (CRPC) remains formidable challenge. Thus, need...
We report the results of a series chemical, EPR, ENDOR, and HYSCORE spectroscopic investigations mechanism action (and inhibition) GcpE, E-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate (HMBPP) synthase, also known as IspG, an Fe(4)S(4) cluster-containing protein. find that epoxide HMBPP when reduced by GcpE generates same transient EPR species observed on addition substrate, 2-C-methyl-D-erythritol-2, 4-cyclo-diphosphate. ENDOR spectra these (using (2)H, (13)C (17)O labeled samples) indicate...
We report an electrochemical gating approach with ∼100% efficiency to tune the conductance of single-molecule 4,4'-bipyridine junctions using scanning-tunnelling-microscopy break junction technique. Density functional theory calculation suggests that aligns molecular frontier orbitals relative electrode Fermi-level, switching molecule from off resonance state "partial" resonance.