A5100332346- Ferroptosis and cancer prognosis
- Neuroscience and Neuropharmacology Research
- Sulfur Compounds in Biology
- Ginseng Biological Effects and Applications
- Parkinson's Disease Mechanisms and Treatments
- Folate and B Vitamins Research
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Heat shock proteins research
- Alkaloids: synthesis and pharmacology
- Lysosomal Storage Disorders Research
- Amino Acid Enzymes and Metabolism
- Hemoglobin structure and function
- Neurotransmitter Receptor Influence on Behavior
- RNA Interference and Gene Delivery
- Apelin-related biomedical research
- COVID-19 diagnosis using AI
- Whipple's Disease and Interleukins
- Neurological diseases and metabolism
- Receptor Mechanisms and Signaling
- PARP inhibition in cancer therapy
- Electromagnetic Fields and Biological Effects
Southwest Medical University
2011-2025
Zigong First People's Hospital
2024-2025
Tulane University
2024
Guangzhou University of Chinese Medicine
2023
Guangdong Pharmaceutical University
2023
Zhengzhou University
2021-2022
Jilin Medical University
2022
Jilin University
2022
Soochow University
2021
First Affiliated Hospital of Soochow University
2021
Prostate cancer (PCa) is witnessing a concerning rise in incidence annually, with the androgen receptor (AR) emerging as pivotal contributor to its growth and progression. Mounting evidence underscores AR's ability recruit cofactors, influencing downstream gene transcription thereby fueling proliferation metastasis of PCa cells. Although, clinical strategies involving AR antagonists provide some relief, managing castration resistant prostate (CRPC) remains formidable challenge. Thus, need...
Abstract Background The gut microbiota can modulate brain function and behavior is increasingly recognized as an important factor in mediating the risk of epilepsy effects seizure interventions. Drug therapy one factors that influence composition intestinal microbiota. Q808 innovative chemical with strong anticonvulsant activity low neurotoxicity. However, studies evaluating effect on microbial communities are lacking. In this study, we aimed to evaluate a pentylenetetrazol (PTZ)—induced...
Poor prognosis of esophageal cancer is associated with limited clinical treatment efficacy and lack targeted therapies. With advances in nanomedicine, nanoparticle drug delivery systems play increasingly important roles tumor by enabling the simultaneous multiple therapeutic agents. We here propose a novel nanovector for combination gene therapy chemotherapy cancer. A lipid (EYLN) was designed to carry doxorubicin (Dox) small interfering RNA against anabolic metabolism LPCAT1, which we...
Abstract Prostate cancer (PCa) is one of the most common malignant tumors in world. Thioredoxin interacting protein (TXNIP) downregulated a variety human and plays an important role tumor suppression. However, expression level biological functions TXNIP PCa have not been identified yet. Therefore, this study aims to investigate PCa. We reported that was significantly decreased associated with clinicopathological features. Overexpression could inhibited PC‐3 cells proliferation, migration,...
Noise has always been an important environmental public health issue for mankind. Although reports exist on hippocampal-dependent spatial learning and memory (LM) impairment due to noise, there are only a few studies that have examined the effects of recovery from noise stress LM impairments. Therefore, present study investigated chronic exposure deficits.In this study, detrimental young male rats in Morris water maze (MWM) were at 1, 10, 20, 30, 40 days after discontinuation 80 dB or 100 4...
Aims: Perioperative acute kidney injury (AKI) resulting from renal ischemia reperfusion (IR) is not conducive to the postoperative surgical recovery. Our previous study demonstrated that reactive oxygen species (ROS) transmitted by gap junction (GJ) composed of connexin32 (Cx32) contributed AKI. However, precise underlying pathophysiologic mechanisms were largely unknown. This focuses on related ROS Cx32 responsible for AKI aggravation. Results: In a set in vivo studies, IR was found cause...
Polybrominated diphenyl ethers (PBDEs), a class of widely used flame retardants, are extensively diffused in the environment. Of particular concern reported highly sensitivity PBDEs children or developmental animals, however, almost no information is available on their potential effects adults and mechanisms still unknown. In present study, we investigated neurotoxic sub-chronic PBDE-47 exposure adult male Sprague-Dawley rats. Thus, PBDE-47, 0.1, 0.5 1 mg/kg per day was administered to rats...
Nonalcoholic fatty liver disease (NAFLD) is a prevalent global condition and common precursor to cancer, yet there currently no specific medication available for its treatment. Ginseng, renowned medicinal dietary properties, has been utilized in NAFLD management, although the precise underlying mechanism remains elusive. To investigate effectiveness of ginsenoside Rd, we employed mouse cell models induce using high-fat diets, oleic acid, palmitic acid. We explored confirmed Rd-induced...
Acrylamide (ACR) is a water-soluble chemical that commonly used in and cosmetic manufacture. Many studies have been carried out to investigate the neurotoxicity mechanisms of ACR, resulting oxidative stress nerve damages. One traditional Chinese medicines notoginsenoside R1 (NR1). However, its mitochondrial-mediated apoptotic effect caused ACR-induced has not reported. Our results shown NR1 resisted induced by ACR upregulating levels thioredoxin-1 (Trx-1) Rat adrenal chromaffin cell tumor...
To investigate whether hydrogen sulfide (H2S) counteracts formaldehyde (FA)-induced cognitive defects and the underlying mechanism is involved in upregulation of hippocampal brain-derived neurotrophic factor (BDNF) expression.The function rats was evaluated by Morris water maze (MWM) test novel object recognition test. The content superoxide dismutase (SOD) malondialdehyde (MDA) hippocampus were detected enzyme-linked immunosorbent assay (ELISA). neuronal apoptosis CA1 region terminal...
Abstract Background Gastric cancer is a common gastrointestinal and currently has the third-highest mortality rate. Research shows that natural compound narciclasine variety of biological activities. The present study aimed to investigate effect on gastric cells its molecular mechanisms determine whether this could be novel therapy for cancer. Methods MTT clone assays were employed detect proliferation cells. cell apoptosis was detected by flow cytometry. formation autophagosomes...