A5106651126- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- HIV Research and Treatment
- Celiac Disease Research and Management
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
BGI Group (China)
2016-2019
China National GeneBank
2017-2019
University of Chinese Academy of Sciences
2017
T cell receptor (TCR) diversity determines the autoimmune responses in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) is closely associated with diseases prognosis prevention. However, characteristics of variations TCR their clinical significance still unknown. Large series patients must be studied order to elucidate effects these variations.Peripheral blood from 877 SLE patients, 206 RA 439 healthy controls (HC) were amplified for repertoire sequenced using a...
Compared to classical antibodies, camel heavy chain antibodies (HCAbs) are smaller in size due lack of the light and first constant domain (CH1 region). The variable regions HCAbs (VHHs) more soluble stable than that conventional (VHs). Even with such simple structure, they still functional antigen binding. Although have been extensively investigated over past two decades, most efforts based upon low throughput sequence analysis, there only limited reports trying analyze describe complete...
Abstract The B cells inhabited in mucosa play a vital role mediating homeostasis with autoantigens and external Ags. Tumor-infiltrating lymphocytes are potential prognostic markers therapeutic agents for cancer. However, the spatial heterogeneity of cell repertoire intestinal tumor-infiltrating colorectal cancer (CRC) remain poorly understood. In this study, we developed an unbiased method to amplify IgH repertoire, as well bioinformatic pipeline process these high-throughput sequencing...
Due to the close genetic background, high similarity of physiology, and susceptibility infectious metabolic diseases with humans, rhesus macaques have been widely used as an important animal model in biomedical research, especially study vaccine development human immune-related diseases. In recent years, high-throughput sequencing based immune repertoire (IR-SEQ) has become a powerful tool dynamic adaptive responses. Several previous studies had analyzed responses B cells HIV-1 trimer or T...