A5107172170- BRCA gene mutations in cancer
- Hematopoietic Stem Cell Transplantation
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Genomics and Rare Diseases
- Genetic factors in colorectal cancer
- Bladder and Urothelial Cancer Treatments
- Chronic Lymphocytic Leukemia Research
- Advanced Neuroimaging Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Acute Lymphoblastic Leukemia research
- Cancer, Hypoxia, and Metabolism
- Nutrition, Genetics, and Disease
- Mesenchymal stem cell research
- Colorectal and Anal Carcinomas
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Phytochemicals and Antioxidant Activities
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Soft tissue tumors and treatment
- Genetic and Environmental Crop Studies
- Soybean genetics and cultivation
Second Xiangya Hospital of Central South University
2017-2024
Central South University
2017-2024
Hainan General Hospital
2017-2023
Inner Mongolia Medical University
2023
Hainan Medical University
2023
City of Hope
2013-2022
Hainan Medical College Hospital
2022
Beijing University of Agriculture
2017-2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2013-2019
Chongqing Medical University
2013-2019
Studies suggest that patients carrying a BRCA variant of uncertain significance (VUS) may have lingering confusion concerning results interpretation. Counseling for uninformative BRCA-negative (UN) is thought to be more straightforward, despite the fact both lead similar methods empiric cancer risk counseling. This study compared surgical choices and perceptions between 71 with VUS 714 UN results. All underwent genetic counseling because personal or family history breast ovarian 1997 2010,...
In germline genetic testing, variants from understudied ancestries have been disproportionately classified as being of uncertain significance. We hypothesized that the rate variant reclassification likewise differs by ancestry. Nonbenign in actionable genes were collected consenting subjects undergoing testing at two Southern California sites September 1996 through December 2016. Variant reclassifications recorded they received, until February 2017 or to benign. Excluding duplicate (same...
Chronomodulated chemotherapy has emerged as a new therapy result of recent studies focusing on the biological clock. It been demonstrated that combination chronomodulated platinum-based drugs and 5-fluorouracil (5-Fu) can significantly improve efficacy reduce incidence adverse events in patients with metastatic colorectal cancer, compared conventional chemotherapy. However, results may be different tumors. Recurrent head neck squamous cell carcinoma (HNSCC) is very difficult to treat, an...
Abstract The B cells inhabited in mucosa play a vital role mediating homeostasis with autoantigens and external Ags. Tumor-infiltrating lymphocytes are potential prognostic markers therapeutic agents for cancer. However, the spatial heterogeneity of cell repertoire intestinal tumor-infiltrating colorectal cancer (CRC) remain poorly understood. In this study, we developed an unbiased method to amplify IgH repertoire, as well bioinformatic pipeline process these high-throughput sequencing...
The prevalence and contribution of BRCA1/2 (BRCA) pathogenic variants (PVs) to the cancer burden in Latin America are not well understood. This study aims address this disparity. BRCA analyses were performed on prospectively enrolled American Clinical Cancer Genomics Community Research Network participants via a combination methods: Hispanic Mutation Panel (HISPANEL) MassARRAY; semiconductor sequencing; copy number variant (CNV) detection. PV probability was calculated using BRCAPRO. Among...
Abstract Seed coat color is an important quality and domestication trait. The adzuki bean has more than a dozen seed colors closely associated with the anthocyanin flavonoid metabolism pathways. In this study, we explored pigment composition of 10 different beans including red, black mottle on gray, golden, green, black, ivory, brown, light brown. results showed that anthocyanins are main in coat. There were no carotenoid or pelargonidin derivatives coats any accessions. Different have...
The adzuki bean (Vigna angularis) is an important grain legume. Fine mapping of quantitative trait loci (QTL) and qualitative genes plays role in gene cloning, molecular-marker-assisted selection (MAS), improvement. However, the genetic control agronomic traits remains poorly understood. Single-nucleotide polymorphisms (SNPs) are invaluable construction high-density maps. We mapped 26 QTLs five related to pigmentation using 1,571 polymorphic SNP markers from genome via...
Exploration remains a critical issue in deep reinforcement learning for an agent to attain high returns unknown environments. Although the prevailing exploration Random Network Distillation (RND) algorithm has been demonstrated be effective numerous environments, it often needs more discriminative power bonus allocation. This paper highlights ``bonus inconsistency'' within RND, pinpointing its primary limitation. To address this issue, we introduce Distributional RND (DRND), derivative of...
The treatment of pediatric severe aplastic anemia (SAA) with allogeneic hematopoietic stem cell transplantation (allo-HSCT), presents major challenges including the risks graft failure, septic complications, and graft-versus-host disease (GVHD). Additive infusions human umbilical cord derived mesenchymal (hUC-MSC) may be administered to improve patient survival. We retrospectively examined 37 patients SAA who received allo-HSCT subsequent hUC-MSC suspension at a dose 1.0 × 106 /kg. times...
In this prospective study, we compared the performance of readout segmentation long variable echo trains diffusion-weighted imaging (RESOLVE DWI) and diffusion kurtosis (DKI) for prediction radiotherapy response in patients with nasopharyngeal carcinoma (NPC). Forty-one NPC were evaluated. All underwent conventional MRI, RESOLVE DWI DKI, before after radiotherapy. MRI every 3 months until 1 year The divided into group (RG; 36/41 patients) no-response (NRG; 5/41 based on follow-up results....
Dysfunctional histone deacetylases (HDACs) elicit unrestrained fibrosis and damage to organs. With regard the link between HDACs fibrosis, this research is practiced decipher concrete mechanism of HDAC3 in hyperuricemia (HN)-induced renal interstitial (RIF) from microRNA-19b-3p/splicing factor 3b subunit 3 (miR-19b-3p/SF3B3) axis.The HN model was established on rats induce RIF by oral administration adenine potassium oxalate. were injected with miR-19b-3p- or HDAC3-related vectors figure out...
Abstract Background: Though germline TP53 pathogenic/likely pathogenic variants (PV) are associated with Li–Fraumeni syndrome, many detected by multigene panels represent aberrant clonal expansion (ACE), most due to hematopoiesis (CH). Discerning ACE/CH from and postzygotic mosaicism (PZM) is critically needed for risk assessment management. Methods: Participants in the Li-Fraumeni & Understanding Progress (LiFT UP) study a PV were eligible. Demographics, personal/family cancer history,...
To investigate temporal lobe microstructural abnormalities and neurocognitive function impairment after concurrent chemoradiotherapy (CCRT) in patients with nasopharyngeal carcinoma (NPC).NPC who underwent CCRT were enrolled. High-resolution diffusion-weighted imaging (DWI) magnetic resonance (MRI) diffusion-kurtosis (DKI) MRI, performed 5 times per patient (once pre-CCRT, 1 week post-CCRT, 3 months 6 12 post-CCRT). Neurocognitive was evaluated by Montreal Assessment (MoCA) twice patient,...
Abstract The aim of the study is to verify effect hyperglycemia on ischemia-reperfusion injury and explore feasibility noninvasive observation ischemic-reperfusion in hyperglycemic ischemic stroke by MRI technique. According duration ischemia blood glucose levels, 40 rats were divided into 2-hr (H-I2h), 6-hr (H-I6h), non- (NH-I2h), (NH-I6h) groups. T2W imaging, DW T2 mapping, T2* DCE, T1 mapping after enhancement sequences acquired before reperfusion approximately 3-hr reperfusion. ADC, T1,...
Birt-Hogg-Dube syndrome (BHD, OMIM#135150) is a rare disease in clinic; it characterized by skin fibrofolliculomas, pulmonary cysts with an increased risk of recurrent pneumothorax, renal cysts, and neoplasms. Previous studies have demonstrated that variants folliculin (FLCN, NM_144997) are mainly responsible for this disease. In research, we enrolled two BHD families applied direct sequencing FLCN to explore the genetic lesions them. Two mutations were identified: one novel deletion variant...
<b><i>Aims:</i></b> To compare the efficacy of hematopoietic stem cell transplantation (HSCT) from human leukocyte antigen (HLA)-haploidentical related donors (RD) and unrelated (URD) in treatment leukemia. <b><i>Methods:</i></b> Ninety-three leukemia patients underwent allogeneic HSCT were divided into two groups: 51 cases RD-HSCT 42 URD-HSCT. In group, a preconditioning regimen with fludarabine (Flu) + busulfan (Bu) cytosine arabinoside...
Holo-lactoferrin (Holo-Lf) is one kind of iron-saturated form lactoferrin. Our study to observe the role Holo-Lf in ferroptosis and radiotherapy breast cancer. Triple negative cancer (TMBC) cells MDA-MB-231 non-TMBC MCF-7 were treated with Apo-Lf Holo-Lf, separately. After 24 h, cell viability was determined by CCK-8. To ferroptosis, Apo-Lf, combine activator Erastin. incubated PI ROS probe. The fluorescence intensity examined CLSM. Besides, also collected for detection GPX-4 expression....
Learning points for cliniciansCASZ1 is a gene associated with cardiomyopathy, yet only limited number of CASZ1 variants linked to DCM have been identified date.Our study reports the first missense pathogenic heterozygous variant (c.559G>A: p. Gly187Ser) DCM.