A5006262914- Congenital heart defects research
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
- Congenital Heart Disease Studies
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Circular RNAs in diseases
- Neuroscience and Neuropharmacology Research
- Genetic and phenotypic traits in livestock
- Tracheal and airway disorders
- Adipose Tissue and Metabolism
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Genetic and Kidney Cyst Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Osteoarthritis Treatment and Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Skin and Cellular Biology Research
- Biosensors and Analytical Detection
- Mesenchymal stem cell research
- Cardiac tumors and thrombi
- Tryptophan and brain disorders
- Connexins and lens biology
ShanghaiTech University
2015-2025
Huadong Hospital
2024-2025
Fudan University
2009-2025
Second Affiliated Hospital of Inner Mongolia Medical University
2019-2025
Second Xiangya Hospital of Central South University
2015-2024
Central South University
2015-2024
First Affiliated Hospital of GuangXi Medical University
2018-2024
Guangxi Medical University
2018-2024
Air Force General Hospital PLA
2024
Ningbo University
2019-2024
Paclitaxel (PTX) is one of the widely used chemotherapy drugs in breast cancer (BC) treatment. Unfortunately, survival rate metastatic BC patients remains poor due to PTX resistance. Therefore, uncovering underlying mechanism behind resistance cells crucial for therapy.The enrichment circular RNA ATP binding cassette subfamily B member 10 (circ-ABCB10), let-7a-5p and dual specificity phosphatase 7 (DUSP7) was measured by quantitative real time polymerase chain reaction (qRT-PCR)...
The reindeer is an Arctic species that exhibits distinctive biological characteristics, for which the underlying genetic basis remains largely unknown. We compared genomes of against those other ruminants and nonruminant mammals to reveal light arrhythmicity, high vitamin D metabolic efficiency, antler growth trait females, docility. validate two genes (CYP27B1 POR) show signs positive selection exhibit higher catalytic activity than ruminants. A mutation upstream CCND1 gene endows extra...
Schizophrenia is a relatively common psychiatric syndrome that affects virtually all brain functions. We investigated the plasma proteome of 22 schizophrenia male patients and 20 healthy controls using two-dimensional gel electrophoresis mass spectrometry. In total, we have identified 66 protein spots in human found seven them showed altered changes patients, as compared to controls, which mainly were acute phase proteins (APPs). Among these APPs, haptoglobin α2 chain (p < 0.001), β...
Two recent genome-wide association studies have identified several novel type 2 diabetes susceptibility variants in intron 15 of the KCNQ1 gene. We aimed to evaluate effects on and metabolic traits population mainland China. Three candidate single nucleotide polymorphisms were genotyped 1,912 individuals with 2,041 normal controls using ligase detection reaction method. confirmed Allele frequency ORs three (SNPs) were: rs2237892 (OR 1.19, 95% CI 1.08–1.31, p = 3.0 × 10−4); rs2237895 1.20,...
An increasing number of experiments have found anomalies in mitochondria the brains psychotics, which suggests that mitochondrial dysfunction or abnormal cerebral energy metabolism might play an important role pathophysiology schizophrenia (SCZ). We adopted a proteomic approach to identify differential effects on cortex and hippocampus protein expression Sprague-Dawley (SD) rats by comparing exposure typical atypical antipsychotic medications. Differential expressions were assessed using...
Telomeres are structures at the ends of eukaryotic chromosomes. They help maintain genomic stability. High oxidative stress can lead to accelerated telomere shortening, which causes premature cell senescence. This is implicated in development type 2 diabetes (T2D). For this reason, we hypothesize that shortening characterize T2D.We investigated association between leukocyte length (LTL) and T2D a retrospective case-control study with sample 4016 Chinese Han subjects (1936 unrelated cases...
The purpose of the present study was to investigate underlying molecular mechanism osteoarthritis (OA) and rheumatoid arthritis (RA) based on microarray profiles. Three human joint fibroblast‐like synoviocytes (FLSs) profiles including 26 OA samples, 33 RA 20 healthy control (HC) samples were downloaded from GEO database. Differentially expressed genes (DEGs) between HC (DEGsOA) (DEGsRA) identified. Co‐expressed specific analysed DEGsOA DEGsRA. Gene ontology, KEGG pathway enrichment, PPI...
Intra-articular trauma typically initiates the overgeneration of reactive oxidative species (ROS), leading to post-traumatic osteoarthritis and cartilage degeneration. Xanthan gum (XG), a branched polysaccharide, has shown its potential in many biomedical fields, but some inherent properties, including undesirable viscosity poor mechanical stability, limit application 3D printed scaffolds for regeneration. In this project, we developed bioprinted XG hydrogels by modifying with methacrylic...
Tinnitus is considered a neurological disorder affecting both auditory and nonauditory networks. This study aimed to investigate the structural brain covariance network in tinnitus patients analyze its altered topological properties. Fifty three primary 67 age- sex-matched healthy controls (HCs) were included. Gray matter volume (GMV) of each participant was extracted using voxel-based morphometry, group-level (SCN) constructed based on GMV participant, graph theoretic analyses performed...
Zika virus (ZIKV) infection can cause fetal developmental abnormalities and Guillain-Barré syndrome in adults. Although progress has been made understanding the link between ZIKV microcephaly, pathology of ZIKV, particularly viral reservoirs human, remains poorly understood. Several studies have shown that compared to serum samples, patients' urine samples often a longer duration persistency higher load. This finding suggests an independent reservoir may exist human urinary system. Despite...
Objective Teriparatide could induce osteoblast differentiation of mesenchymal stem cells while inhibiting adipocyte differentiation. However, there are significant differences between ex vivo and in models. We aimed to evaluate the impact teriparatide on marrow abdominal fat accumulation postmenopausal osteopenic women.
Three-dimensional (3D) bioink with favorable printability, strength, and biocompatibility challenged the 3D bioprinting technology in cartilage tissue engineering. Herein, we innovatively fabricated photo-crosslinkable methacrylated konjac glucomannan (KGMMA) as a novel biomaterial ink for extrusion an attempt to construct precisely patterned tissues. Specifically, (KGM) was modified by methacrylic anhydride, which is kind of photoreactive group, form KGMMA. After UV crosslinking, printed...
Alteration in transforming growth factor-β (TGF-β) signaling pathway is one of the main causes esophageal squamous cell carcinoma (ESCC). The human runt-related transcription factor 3 (RUNX3), an important component TGF-β which located at 1p36, commonly deleted a variety cancers, including ESCC. Hypermethylation RUNX3 promoter was frequently found gastrointestinal those stomach, liver, colon and pancreas. However, methylation status ESCC has not been studied. aim this study to determine...