A5046479885- CRISPR and Genetic Engineering
- Aquaculture Nutrition and Growth
- Crustacean biology and ecology
- RNA and protein synthesis mechanisms
- RNA Interference and Gene Delivery
- Animal Genetics and Reproduction
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Agronomic Practices and Intercropping Systems
- Biochemical Analysis and Sensing Techniques
- Seed Germination and Physiology
- Weed Control and Herbicide Applications
- Adipose Tissue and Metabolism
- Virus-based gene therapy research
- Allelopathy and phytotoxic interactions
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Bacteriophages and microbial interactions
- Plant Pathogens and Fungal Diseases
- Plant-Microbe Interactions and Immunity
- Fungal Plant Pathogen Control
Foshan University
2016-2025
Hunan Normal University
2025
University of Chinese Academy of Sciences
2025
Beijing National Laboratory for Molecular Sciences
2025
Chinese Academy of Sciences
2025
Institute of Chemistry
2025
Jinan University
2005-2019
First Affiliated Hospital of Sichuan Medical University
2014
Guangdong Hydropower Planning & Design Institute
2012-2013
First Hospital of Jiaxing
2012
Recent research has demonstrated that activating the cGAS-STING pathway can enhance interferon production and activation of T cells. A manganese complex, called TPA-Mn, was developed in this context. The reactive oxygen species (ROS)-sensitive nanoparticles (NPMn) loaded with TPA-Mn are developed. NPMn activates via cGAS (i.e., 1.6-fold enhancement P-STING), which turn increases secretion pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-2). This promotes dendritic cell maturation, enhances...
Abstract Hybrid excitons formed via resonant hybridization in 2D material heterostructures feature both large optical and electrical dipoles, providing a promising platform for many‐body exciton physics correlated electronic states. However, hybrid at organic–inorganic interface combining the advantages of Wannier–Mott Frenkel remain elusive. Here, are reported copper phthalocyanine/molybdenum diselenide (CuPc/MoSe 2 ) heterostructure (HS) featuring strong molecular orientation dependence by...
Cancer-associated fibroblasts (CAFs) have been described to play critical roles in initiation, progression and metastasis of various cancers. However, the involvement CAFs oral cancer (OC) has not well addressed. In this study, we demonstrate that CAFs, when cocultured with OC cells (OCCs), produce high levels chemokine (C-C motif) ligand 2 (CCL2) and, subsequently, enhance endogenous reactive oxygen species production cells. Oxidative stress stimulates expression cell cycle proteins OCCs,...
ABSTRACT Gene edited pigs have extensive and important application value in the fields of agriculture biomedicine. With increasing demand medical research agricultural markets, more scenarios require gene to possess two or even advantageous phenotypes simultaneously. The current production multi is inefficient, time‐consuming, costly, there an urgent need develop efficient accurate editing technologies. polycistronic tRNA‐gRNA‐processing system (PTG), developed based on endogenous tRNA...
Background/Objectives: Fat deposition traits in pigs directly influence pork flavor, tenderness, and juiciness are closely linked to overall quality. The Tibetan pig, an indigenous breed China, not only possesses a high intramuscular fat content but also exhibits unique metabolism pattern due long-term adaptation harsh environments. This makes it excellent genetic physiological model for investigating characteristics. Adipose tissue from different body regions displays varying morphologies,...
The objective of this paper is to present a case study derive land use/land cover (LULC) maps and investigate the long-term effects LULC change on surface runoff in fast urbanizing Beijing city. were derived from Landsat TM/ETM+ imagery (acquired 1992, 1999, 2006, 2009) using support vector machine method. A hydrologic impact assessment model was applied assess runoff. Results indicated that selected area experienced rapid urbanization 1992 2009. Because urbanization, 2009, modeled increased...
Background: The characteristic of oral submucous fibrosis (OSF) is related with the disturbance synthesis and degradation extracellular matrix. Arecoline, areca nut (betel nut) component betel quid, plays a major role in pathogenesis OSF. But exact mechanism how arecoline influences collagen metabolism unclear. Methods: Oral keratinocytes fibroblasts were cocultured pre‐treated by arecoline. Fibroblasts alone, stimulated arecoline, keratinocyte included as four groups present study....
Adipose tissue, an indispensable organ, fulfils the pivotal role of energy storage and metabolism is instrumental in maintaining dynamic equilibrium health organism. Adipocyte hypertrophy adipocyte hyperplasia (adipogenesis) are two primary mechanisms fat deposition. Mature adipocytes obtained by differentiating mesenchymal stem cells into preadipocytes redifferentiation. However, orchestrating adipogenesis remain unclear. Autophagy, alternative cell death pathway that sustains intracellular...
Bama minipigs are a local pig breed that is unique to China and has high development utilization value. However, its fat content, low feed rate, slow growth rate have limited popularity utilization. Compared with the long breeding cycle cost of traditional genetic pigs, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) endonuclease 9 system (CRISPR/Cas9)-mediated gene editing can cost-effectively implement targeted mutations in animal genomes, thereby...
Leptin is a peripheral satiety hormone that also plays important roles in energy homeostasis vertebrates ranging from fish to mammals. In teleost fish, however, the regulatory mechanism for leptin gene expression still remains unclear. this study, we found glucagon, key glucose homeostasis, was effective at elevating leptin-AI and leptin-AII transcript levels goldfish liver via both vivo intraperitoneal injection vitro cells incubation approaches. The responses of mRNA glucagon treatment...
To date, studies on apoptosis in echinoderms mainly focus the caspase-dependent extrinsic apoptotic pathway, while knowledges regarding intrinsic pathway is still limited. In this study, 55 genes belong to 7 families of namely, Bcl-2, caspase, AIF, Cyt c, Apaf-1, Smac, HTRA2 and Endo G, were identified by screening genomic database tropical sea cucumber Holothuria leucospilota. The Bcl-2 family showed significant gene expansion H. leucospilota but not other echinoderms, pro-apoptotic factor...
Leptin actions at the pituitary level have been extensively investigated in mammalian species, but remain insufficiently characterized lower vertebrates, especially teleost fish. Prolactin (PRL) is a hormone of central importance to osmoregulation Using goldfish as model, we examined global and brain-pituitary distribution leptin receptor (lepR) relationship between expression lepR major hormones different regions. The effects recombinant leptin-AI leptin-AII on PRL mRNA were further...
Receptor-interacting protein kinases (RIPKs) and mixed-lineage kinase domain-like (MLKL) are crucial in regulating innate immune responses cell death signaling (necroptosis apoptosis), potential candidates for genetic improvement breeding programs. Knowledge about the RIPK family MLKL sea cucumber remains limited.
Abstract Background The red swamp crayfish Procambarus clarkii is a freshwater species that possesses high adaptability, environmental tolerance, and fecundity. P. artificially farmed on large scale in China. However, the molecular mechanisms of ovarian development remain largely unknown. In this study, we identified four stages ovary development, previtellogenic stage (stage I), early vitellogenic II), middle III), mature IV) compared transcriptomics among these through next-generation...