A5048038908- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- CRISPR and Genetic Engineering
- Extracellular vesicles in disease
- RNA regulation and disease
- Traditional Chinese Medicine Analysis
- Cardiac Ischemia and Reperfusion
- Dementia and Cognitive Impairment Research
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Virus-based gene therapy research
- Ginseng Biological Effects and Applications
- Neurological Disease Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- Medicinal Plants and Bioactive Compounds
- Inflammasome and immune disorders
- Adipose Tissue and Metabolism
- RNA Interference and Gene Delivery
China Geological Survey
2025
Tsinghua University
2025
Shenzhen Technology University
2021-2025
China Medical University
2015-2024
Xinjiang Medical University
2011-2024
First Affiliated Hospital of Xinjiang Medical University
2011-2024
Clinical Trial Investigators
2024
First Affiliated Hospital of Xiamen University
2024
Foshan University
2019-2023
Wuhan University
2020-2022
Abstract Cardiac progenitor cells derived from adult heart have emerged as one of the most promising stem cell types for cardiac protection and repair. Exosomes are known to mediate cell–cell communication by transporting cell-derived proteins nucleic acids, including various microRNAs (miRNAs). Here we investigated (CPC)-derived exosomal miRNAs on protecting myocardium under oxidative stress. Sca1 + CPCs-derived exosomes were purified conditional medium, identified nanoparticle trafficking...
Background and Purpose— Long noncoding RNA H19 is repressed after birth, but can be induced by hypoxia. We aim to investigate the impact on underlying mechanism of induction ischemic stroke. Methods— Circulating levels in stroke patients mice subjected middle cerebral artery occlusion were assessed using real-time polymerase chain reaction. siRNA histone deacetylase 1 (HDAC1) plasmid used knock down overexpress HDAC1, respectively. Microglial polarization outcomes BV2 microglial cells...
Long non-coding RNA H19 (lncRNA H19) was found to be upregulated by hypoxia, its expression and function have never been tested in cerebral ischemia reperfusion (I/R) injury. This study intended investigate the role of lncRNA gene variation I/R injury with focusing on relationship autophagy activation. Cerebral induced rats middle artery occlusion followed reperfusion. SH-SY5Y cells were subjected oxygen glucose deprivation (OGD/R) simulate Real-time PCR, flow cytometry, immunofluorescence...
<h3>Importance</h3> Preclinical and clinical studies have suggested a neuroprotective effect of remote ischemic conditioning (RIC), which involves repeated occlusion/release cycles on bilateral upper limb arteries; however, robust evidence in patients with stroke is lacking. <h3>Objective</h3> To assess the efficacy RIC for acute moderate stroke. <h3>Design, Setting, Participants</h3> This multicenter, open-label, blinded–end point, randomized trial including 1893 was conducted at 55...
Abstract Dysregulation of long noncoding RNAs (lncRNAs) is associated with abnormal development and pathophysiology in the brain. Increasing evidence has indicated that ischemic stroke becoming most common cerebral disease aging populations. The treatment challenging, due part to ischemia reperfusion (I/R) injury. In this study, we revealed potassium voltage‐gated channel subfamily Q member 1 opposite strand (KCNQ1OT1) was significantly upregulated stroke. Knockdown KCNQ1OT1 remarkably...
Context: Hypoxic-ischemic encephalopathy (HIE) has a high morbidity and mortality rate. Resveratrol possesses numerous biological properties including antioxidant, anti-inflammatory neuroprotective activities.Objective: The current experiment investigates the efficacy of resveratrol (RESV) against HIE by modulating Nrf2/HO-1 pathway in neonatal rats.Materials methods: Seven-day-old pups (n = 48) were divided into four groups. Group-I rats receiving 2% DMSO saline (sham), group-II underwent...
Mitochondrial dysfunction leads to reactive oxygen species (ROS) overload, exacerbating injury in myocardial infarction (MI). As a receptor for translocases the outer mitochondrial membrane (Tom) complex, Tom70 has an unknown function MI, including melatonin-induced protection against MI injury. We delivered specific small interfering RNAs or lentivirus vectors carrying Tom70a sequences into left ventricles of mice cultured neonatal murine ventricular myocytes (NMVMs). At 48 h...
Multiple sclerosis (MS) is a chronic autoimmune and degenerative disease of the central nervous system, conventional treatments have limited efficacy or side effects. Ghrelin, 28-amino acid octanoylated peptide, has been reported to neuroprotective effects, including anti-oxidation, anti-inflammation, anti-apoptosis. Pyroptosis, also called inflammatory cell death, triggered by overly active inflammasomes accompanied production numerous cytokines. As immune dysfunction primarily involved in...
Carbonylation is a highly prevalent protein modification in skeletal muscle mitochondria, possibly contributing to its functional decline with age. Using quantitative proteomics, we identified mitochondrial proteins susceptible carbonylation type (slow- vs fast-twitch)-dependent and age-dependent manner from Fischer 344 rat muscle. Fast-twitch contained twice as many carbonylated than did slow-twitch muscle, 22 showing significant changes state age, the majority of these increasing their...
Long noncoding RNAs (lncRNAs) have been acknowledged as important regulators in various human cancers. lncRNA MNX1-AS1 has shown to be an oncogene epithelial ovarian cancer. However, the function of glioblastoma (GBM) remains largely unknown. Here we found that expression was significantly upregulated GBM tissues and cell lines. Knockdown inhibited proliferation, migration, invasion cells. In terms mechanism, could bind miR-4443 Overexpression vice versa. Moreover, there inverse correlation...