A5100402578- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Traditional Chinese Medicine Studies
- Cardiac Fibrosis and Remodeling
- MicroRNA in disease regulation
- Acupuncture Treatment Research Studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Traditional Chinese Medicine Analysis
- Medical Research and Treatments
- Transplantation: Methods and Outcomes
- Healthcare and Venom Research
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Neurological Disease Mechanisms and Treatments
- Ion Transport and Channel Regulation
- Cardiovascular Disease and Adiposity
- Mitochondrial Function and Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Signaling Pathways in Disease
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Children's Hospital of Chongqing Medical University
2009-2025
Chongqing Medical University
2009-2025
Air Force Medical University
2013-2025
Xijing Hospital
2013-2025
Central South University
2025
Second Xiangya Hospital of Central South University
2025
Jinhua Polytechnic
2025
Hubei University of Chinese Medicine
2001-2025
University of Toronto
2005-2024
Sun Yat-sen University
2005-2024
rIPC (remote ischaemic preconditioning) is a phenomenon whereby short periods of ischaemia and reperfusion tissue or organ (e.g. mesentery, kidney) can protect distant heart) against subsequent, potentially lethal, ischaemia. We, others, have shown that transient limb provide potent myocardial protection experimentally clinically during cardiac surgery. Nonetheless, our understanding the signal transduction from remote stimulus to local effect remains incomplete. The aim present study was...
Abstract Chronic heart failure (CHF) is the final outcome of many cardiovascular diseases, and a severe health issue faced by elderly population. Mixed lineage kinase 3 (MLK3), member MAP3K family, associated with aging, inflammation, oxidative stress, related such as CHF. MLK3 has also been reported to play an important role in protecting against cardiomyocyte injury; however, its function myocardial fibrosis unknown. To investigate fibrosis, we inhibited expression MLK3, examined cardiac...
<h3>Importance</h3> Preclinical and clinical studies have suggested a neuroprotective effect of remote ischemic conditioning (RIC), which involves repeated occlusion/release cycles on bilateral upper limb arteries; however, robust evidence in patients with stroke is lacking. <h3>Objective</h3> To assess the efficacy RIC for acute moderate stroke. <h3>Design, Setting, Participants</h3> This multicenter, open-label, blinded–end point, randomized trial including 1893 was conducted at 55...
Remote ischemic preconditioning (RIPC) induced by transient limb ischemia releases a dialysable circulating protective factor that reduces ischemia-reperfusion injury. Exercise performance in highly trained athletes is limited tissue hypoxemia and acidosis, which may therefore represent type of stress modifiable RIPC.National-level swimmers, 13-27 yr, were randomized to RIPC (four cycles 5-min arm ischemia/5-min reperfusion) or low-pressure control procedure, with crossover. In study 1,...
Rationale: Remote ischemic conditioning induced by repeated episodes of transient limb ischemia is a clinically applicable method for protecting the heart against injury at time reperfusion. Objective: To assess effect chronic, repeated, remote on infarct size and long-term remodeling after myocardial infarction. Methods Results: Rats with ischemia/reperfusion received different protocols conditioning. While single early episode during coronary occlusion (perconditioning) resulted in...
Endoplasmic reticulum (ER) stress is activated during and contributes to ischemia-reperfusion (I/R) injury. Attenuation of ER stress-induced apoptosis protects the heart against I/R Using apelin, a ligand used activate apelin APJ receptor, which known be cardioprotective, this study was designed investigate 1) time course changes in injury after stress; 2) whether infusion via modulation stress-dependent signaling pathways; 3) how phosphatidylinositol 3-kinase (PI3K)/Akt, endothelial nitric...
AimsCardiac allograft vasculopathy (CAV) is a major limitation to long-term survival following cardiac transplantation. Conventional imaging modalities such as angiography and intravascular ultrasound fail characterize CAV plaque morphology. Our aim was in vivo using the high spatial resolution of intracoronary optical coherence tomography (OCT).
To evaluate the safety and efficacy of extracorporeal membrane oxygenation (ECMO) combined with fiberoptic bronchoscopy in children life-threatening pulmonary hemorrhage that does not respond to conventional mechanical ventilation. From October 2019 June 2022, four pediatric patients requiring ECMO support were admitted our hospital. Based on their weight vascular conditions, either venoarterial (VA)-ECMO or venovenous (VV)-ECMO was selected. The anticoagulation strategy tailored, performed...
Arrays of aligned, multiwalled carbon nanotubes were produced by catalytically pyrolyzing acetylene within the pores an anodic aluminum oxide template. Small cobalt catalyst particles predeposited electrochemically at bottom pores. The tube walls consisted approximately 10 layers with interlayer spacing 3.45 Å, somewhat larger than 3.35 Å interplanar graphite. found to be open one end, making it possible fill tubes metals or other materials. Nickel and deposited in interior using nanoscale...
We examined the importance of Rho family GTPase Rac1 for cyclin D<sub>1</sub> promoter transcriptional activation in bovine tracheal myocytes. Overexpression active induced transcription from promoter, whereas platelet-derived growth factor (PDGF)-induced was inhibited by a dominant-negative allele Rac1, suggesting that functions as an upstream activator this system. forms part NADPH oxidase complex generates reactive oxygen species such H<sub>2</sub>O<sub>2</sub>. PDGF stimulated...
Rational : Vascular smooth muscle cells (VSMCs) switching from a contractile/differentiated to synthetic/dedifferentiated phenotype has an essential role in atherosclerosis, postangioplastic restenosis and hypertension. However, how normal VSMCs maintain the differentiated state is less understood. Objective We aimed indentify effect of cartilage oligomeric matrix protein (COMP), vascular extracellular matrix, on modulation phenotype. Methods Results demonstrated that COMP was associated...
We have previously shown that remote ischemic preconditioning (rIPC) by transient limb ischemia leads to the release of a circulating factor(s) induces potent myocardial protection. Intra-arterial injection adenosine into also cardioprotection, but mechanism its signal transduction is poorly understood. Eleven groups rabbits received saline control or rIPC administration with additional pretreatment nitric oxide (NO) synthase blocker N(G)-nitro-l-arginine methyl ester, NO donor...
Ischemic postconditioning (PostC) and perconditioning (PerC) provide practical methods for protecting the heart against ischemia-reperfusion (I/R) injury, but their combined effects have not been studied in detail. Using an vivo rat I/R model, we tested 1) whether additive were produced when local PostC was preceded by varying doses of remote PerC, optimal PostC+PerC regime is to ischemic preconditioning (IPC), 2) how alters activity reperfusion injury salvage kinase pathway. The combination...
Six new epipolythiodioxopiperazine (ETP) alkaloids, penicisulfuranols A–F (1–6), were isolated from the mangrove endophytic fungus Penicillium janthinellum HDN13-309. All structures including absolute configurations elucidated on basis of comprehensive spectroscopic data and ECD calculations. They belong to unusual family ETPs containing sulfur atoms both α- β-positions amino acid residues a rare 1,2-oxazadecaline core moiety. In addition, compounds 1–6 also possess spiro-furan ring 1–3...
The pressure-loaded right ventricle (RV) adversely affects left ventricular (LV) function. We recently found that these ventricular-ventricular interactions lead to LV myocardial fibrosis through transforming growth factor-β1 (TGF-β1) signaling. investigated the mechanisms mediating biventricular in RV afterload and their potential modification by angiotensin receptor blockade. An adjustable pulmonary artery band (PAB) was placed rabbits. In sham-operated control rabbits, uninflated (n = 6)....
Three new isocoumarins—dichlorodiaportintone (1), desmethyldichlorodiaportintone (2) and desmethyldichlorodiaportinol (3)—as well as six known analogues (4–9) were isolated from the culture of mangrove endophytic fungus Ascomycota sp. CYSK-4 Pluchea indica. Their structures elucidated by analysis spectroscopic data. The absolute configuration compounds 1 2 determined modified Mosher’s method. Compound showed significant anti-inflammatory activity inhibiting production NO in LPS-induced RAW...
Therapeutic advances for pulmonary hypertension (PH) have been incremental because of the focus on vasculature in PH pathology. Here, we evaluate concept that is, rather, a systemic disorder involving interplay among multiorgan systems, including brain, gut, and lungs. Therefore, objective this study was to hypothesis is associated with dysfunctional brain-gut-lung axis global overexpression ACE2 (angiotensin-converting enzyme 2) rebalances protects against PH. knockin wild-type (WT;...